Hypothyroid state does not protect but delays neuronal death in the hippocampal CA1 region following transient cerebral ischemia: Focus on oxidative stress and gliosis

Journal of Neuroscience Research

Volumn 88, Issue 12, 2010, Pages 2661-2668

  Lee, Choong Hyun ^a   Yoo, Ki Yeon ^a   Hwang, In Koo ^b   Choi, Jung Hoon ^a   Park, Ok Kyu ^a   Li, Hua ^a   Kang, Il Jun ^a   Kwon, Young Guen ^c   Kim, Young Myeong ^d   Won, Moo Ho ^a  

^a Hallym University   (South Korea)

^b Seoul National University   (South Korea)

^c Yonsei University   (South Korea)

^d Kangwon National University   (South Korea)

Author keywords

Cu,Zn superoxide dismutase; Delayed neuronal death; Gliosis; Hypothyroidism; Ischemia

Indexed keywords

4 HYDROXYNONENAL; CALCIUM BINDING PROTEIN; COPPER ZINC SUPEROXIDE DISMUTASE; GLIAL FIBRILLARY ACIDIC PROTEIN; IONIZED CALCIUM BINDING ADAPTER MOLECULE 1; LIOTHYRONINE; NEURON SPECIFIC NUCLEAR PROTEIN; THIAMAZOLE; THYROXINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN ISCHEMIA; BRAIN REGION; CELL ACTIVATION; CELL DEATH; CONTROLLED STUDY; FREE LIOTHYRONINE INDEX; FREE THYROXINE INDEX; GERBIL; GLIOSIS; HIPPOCAMPUS; HYPOTHYROIDISM; IMMUNOREACTIVITY; LIOTHYRONINE BLOOD LEVEL; LIPID PEROXIDATION; MALE; MICROGLIA; NERVE CELL; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REPERFUSION INJURY; THYROXINE BLOOD LEVEL; TRANSIENT CEREBRAL ISCHEMIA;

ANIMALS; ANTITHYROID AGENTS; BRAIN ISCHEMIA; CA1 REGION, HIPPOCAMPAL; CELL DEATH; CYTOPROTECTION; GERBILLINAE; GLIOSIS; HYPOTHYROIDISM; LIPID PEROXIDATION; MALE; METHIMAZOLE; NEURONS; OXIDATIVE STRESS; REPERFUSION INJURY; SUPEROXIDE DISMUTASE;

EID: 77955475115     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22436     Document Type: Article

References (35)

1. Aliciguzel Y, Ozdem SN, Ozdem SS, Karayalcin U, Siedlak SL, Perry G, Smith MA. 2001. Erythrocyte, plasma, and serum antioxidant activities in untreated toxic multinodular goiter patients. Free Radic Biol Med 30:665-670. (Pubitemid 32280792)
2. Alzoubi KH, Aleisa AM, Gerges NZ, Alkadhi KA. 2006. Nicotine reverses adult-onset hypothyroidism-induced impairment of learning and memory: Behavioral and electrophysiological studies. J Neurosci Res 84:944-953.
3. Aniello F, Couchie D, Bridoux AM, Gripois D, Nunez J. 1991. Splicing of juvenile and adult tau mRNA variants is regulated by thyroid hormone. Proc Natl Acad Sci U S A 88:4035-4039.
4. Bal-Price A, Brown GC. 2001. Inflammatory neurodegeneration mediated by nitric oxide from activated glia-inhibiting neuronal respiration, causing glutamate release and excitotoxicity. J Neurosci 21:6480-6491. (Pubitemid 32781092)
5. Bonnekoh P, Barbier A, Oschlies U, Hossmann KA. 1990. Selective vulnerability in the gerbil hippocampus: morphological changes after 5-min ischemia and long survival times. Acta Neuropathol 80:18-25.
6. Brown JG, Millward DJ. 1983. Dose response of protein turnover in rat skeletal muscle to triiodothyronine treatment. Biochim Biophys Acta 757:182-190.
7. Calza L, Aloe L, Giardino L. 1997. Thyroid hormone-induced plasticity in the adult rat brain. Brain Res Bull 44:549-557.
8. Candelario-Jalil E, Mhadu NH, Al-Dalain SM, Martinez G, Leon OS. 2001. Time course of oxidative damage in different brain regions following transient cerebral ischemia in gerbils. Neurosci Res 41:233-241. (Pubitemid 32988398)
9. Chopra IJ. 1996. Nonthyroidal illness syndrome or euthyroid sick syndrome? Endocr Pract 2:45-52.
10. Engstrom G, Svensson TH, Waldeck B. 1974. Thyroxine and brain catecholamines: increased transmitter synthesis and increased receptor sensitivity. Brain Res 77:471-483.
11. Esterbauer H, Schaur RJ, Zollner H. 1991. Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 11:81-128.
12. Galinanes M, Smolenski RT, Haddock PS, Hearse DJ. 1994. Early effects of hypothyroidism on the contractile function of the rat heart and its tolerance to hypothermic ischemia. J Thorac Cardiovasc Surg 107:829-837. (Pubitemid 24100461)
13. Giulian D, Li J, Leara B, Keenen C. 1994. Phagocytic microglia release cytokines and cytotoxins that regulate the survival of astrocytes and neurons in culture. Neurochem Int 25:227-233.
14. Golombek SG. 2008. Nonthyroidal illness syndrome and euthyroid sick syndrome in intensive care patients. Semin Perinatol 32:413-418.
15. Gredilla R, Barja G, Lopez-Torres M. 2001a. Effect of short-term caloric restriction on H2O2 production and oxidative DNA damage in rat liver mitochondria and location of the free radical source. J Bioenerg Biomembr 33:279-287. (Pubitemid 33029007)
16. Gredilla R, Sanz A, Lopez-Torres M, Barja G. 2001b. Caloric restriction decreases mitochondrial free radical generation at complex I and lowers oxidative damage to mitochondrial DNA in the rat heart. FASEB J 15:1589-1591.
17. Hsu JY, Stein SA, Xu XM. 2008. Abnormal growth of the corticospinal axons into the lumbar spinal cord of the hyt/hyt mouse with congenital hypothyroidism. J Neurosci Res 86:3126-3139.
18. Hwang IK, Yoo KY, Kim DW, Choi SY, Kang TC, Kim YS, Won MH. 2006. Ionized calcium-binding adapter molecule 1 immunoreactive cells change in the gerbil hippocampal CA1 region after ischemia/ reperfusion. Neurochem Res 31:957-965.
19. Hwang IK, Yoo KY, Li H, Park OK, Lee CH, Choi JH, Jeong YG, Lee YL, Kim YM, Kwon YG, Won MH. 2009. Indole-3-propionic acid attenuates neuronal damage and oxidative stress in the ischemic hippocampus. J Neurosci Res 87:2126-2137.
20. Janac B, Radenovic L, Selakovic V, Prolic Z. 2006. Time course of motor behavior changes in Mongolian gerbils submitted to different durations of cerebral ischemia. Behav Brain Res 175:362-373.
21. Martin JV, Williams DB, Fitzgerald RM, Im HK, Vonvoigtlander PF. 1996. Thyroid hormonal modulation of the binding and activity of the GABAA receptor complex of brain. Neuroscience 73:705-713.
22. McIntosh LM, Pernitsky AN, Anderson JE. 1994. The effects of altered metabolism (hypothyroidism) on muscle repair in the mdx dystrophic mouse. Muscle Nerve 17:444-453.
23. McKracken E, Graham DI, Nilsen M, Stewart J, Nicoll JA, Horsburgh K. 2001. 4-Hydroxynonenal immunoreactivity is increased in human hippocampus after global ischemia. Brain Pathol 11:414-421. (Pubitemid 32777499)
24. Paller MS. 1986. Hypothyroidism protects against free radical damage in ischemic acute renal failure. Kidney Int 29:1162-1166.
25. Porterfield SP, Hendrich CE. 1993. The role of thyroid hormones in prenatal and neonatal neurological development - current perspectives. Endocr Rev 14:94-106.
26. Rastogi L, Godbole MM, Ray M, Rathore P, Pradhan S, Gupta SK, Pandey CM. 2006. Reduction in oxidative stress and cell death explains hypothyroidism induced neuroprotection subsequent to ischemia/reperfusion insult. Exp Neurol 200:290-300.
27. Shuaib A, Ijaz S, Hemmings S, Galazka P, Ishaqzay R, Liu L, Ravindran J, Miyashita H. 1994a. Decreased glutamate release during hypothyroidism may contribute to protection in cerebral ischemia. Exp Neurol 128:260-265.
28. Shuaib A, Ijaz S, Mazagri R, Kalra J, Hemmings S, Senthilsvlvan A, Crosby N. 1994b. Hypothyroidism protects the brain during transient forebrain ischemia in gerbils. Exp Neurol 127:119-125. (Pubitemid 24199228)
29. Stoll G, Jander S, Schroeter M. 1998. Inflammation and glial responses in ischemic brain lesions. Prog Neurobiol 56:149-171.
30. Sugawara T, Lewen A, Noshita N, Gasche Y, Chan PH. 2002. Effects of global ischemia duration on neuronal, astroglial, oligodendroglial, and microglial reactions in the vulnerable hippocampal CA1 subregion in rats. J Neurotrauma 19:85-98.
31. Swaroop A, Ramasarma T. 1985. Heat exposure and hypothyroid conditions decrease hydrogen peroxide generation in liver mitochondria. Biochem J 226:403-408. (Pubitemid 15137248)
32. Urabe T, Yamasaki Y, Hattori N, Yoshikawa M, Uchida K, Mizuno Y. 2000. Accumulation of 4-hydroxynonenal-modified proteins in hippocampal CA1 pyramidal neurons precedes delayed neuronal damage in the gerbil brain. Neuroscience 100:241-250.
33. Venditti P, De Rosa R, Di Meo S. 2003. Effect of thyroid state on susceptibility to oxidants and swelling of mitochondria from rat tissues. Free Radic Biol Med 35:485-494. (Pubitemid 37289158)
34. Voll CL, Auer RN. 1988. The effect of postischemic blood glucose levels on ischemic brain damage in the rat. Ann Neurol 24:638-646.
35. Wang Q, Tompkins KD, Simonyi A, Korthuis RJ, Sun AY, Sun GY. 2006. Apocynin protects against global cerebral ischemia-reperfusioninduced oxidative stress and injury in the gerbil hippocampus. Brain Res 1090:182-189.