Glutamate dehydrogenase for laboratory diagnosis of Clostridium difficile infection

Journal of Clinical Microbiology

Volumn 48, Issue 8, 2010, Pages 3050-3051

  Goldenberg, Simon D ^a   Cliff, Penny R ^a   French, Gary L ^a  

^a GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE DEHYDROGENASE; BACTERIAL TOXIN; CLOSTRIDIUM DIFFICILE LETHAL TOXIN B; ENTEROTOXIN; TCDA PROTEIN, CLOSTRIDIUM DIFFICILE;

CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM DIFFICILE INFECTION; COST BENEFIT ANALYSIS; ENZYME ANALYSIS; ENZYME IMMUNOASSAY; FALSE POSITIVE RESULT; LABORATORY DIAGNOSIS; LETTER; NONHUMAN; PREVALENCE; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; DIAGNOSTIC PROCEDURE; ECONOMICS; ENTEROCOLITIS, PSEUDOMEMBRANOUS; ENZYMOLOGY; EVALUATION STUDY; FECES; HUMAN; IMMUNOLOGY; ISOLATION AND PURIFICATION; MICROBIOLOGICAL EXAMINATION; MICROBIOLOGY; PEPTOCLOSTRIDIUM DIFFICILE; PROCEDURES;

BACTERIAL TOXINS; BACTERIOLOGICAL TECHNIQUES; CLOSTRIDIUM DIFFICILE; ENTEROCOLITIS, PSEUDOMEMBRANOUS; ENTEROTOXINS; FECES; GLUTAMATE DEHYDROGENASE; HUMANS; IMMUNOENZYME TECHNIQUES; LABORATORY TECHNIQUES AND PROCEDURES; SENSITIVITY AND SPECIFICITY; CLINICAL LABORATORY TECHNIQUES;

CLOSTRIDIUM DIFFICILE;

EID: 77955463857     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.01074-10     Document Type: Letter

References (11)

1. Eastwood, K., P. Else, A. Charlett, and M. Wilcox. 2009. Comparison of nine commercially available Clostridium difficile toxin detection assays, a real-time PCR assay for Clostridium difficile tcdB, and a glutamate dehydrogenase detection assay to cytotoxin testing and cytotoxigenic culture methods. J. Clin. Microbiol. 47:3211-3217.
2. Gilligan, P. H. 2008. Is a two-step glutamate dehydrogenase antigen-cytotoxicity neutralization assay algorithm superior to the Premier toxin A and B enzyme immunoassay for laboratory detection of Clostridium difficile? J. Clin. Microbiol. 46:1523-1525.
3. Goldenberg, S. D., P. R. Cliff, S. Smith, M. Milner, and G. L. French. 2010. Two-step glutamate dehydrogenase antigen real-time polymerase chain reaction assay for detection of toxigenic Clostridium difficile. J. Hosp. Infect. 74:48-54.
4. Goldenberg, S. D., T. Dieringer, and G. L. French. 2010. Detection of toxigenic Clostridium difficile in diarrheal stools by rapid real-time polymerase chain reaction. Diagn. Microbiol. Infect. Dis. 67:304-307.
5. Health Protection Agency. August 2009. Healthcare-associated infections in England: 2008-2009 report. Health Protection Agency, London, United Kingdom.
6. Kvach, E. J., D. Ferguson, P. F. Riska, and M. L. Landry. 2010. Comparison of BD GeneOhm Cdiff real-time PCR assay with a two-step algorithm and a toxin A/B enzyme-linked immunosorbent assay for diagnosis of toxigenic Clostridium difficile infection. J. Clin. Microbiol. 48:109-114.
7. Larson, A. M., A. M. Fung, and F. C. Fang. 2010. Evaluation of tcdB real-time PCR in a three-step diagnostic algorithm for detection of toxigenic Clostridium difficile. J. Clin. Microbiol. 48:124-130.
8. Novak-Weekley, S. M., E. M. Marlowe, J. M. Miller, J. Cumpio, J. H. Nomura, P. H. Vance, and A. Weissfeld. 2010. Clostridium difficile testing in the clinical laboratory using multiple testing algorithms. J. Clin. Microbiol. 48:889-893.
9. Planche, T., A. Aghaizu, R. Holliman, P. Riley, J. Poloniecki, A. Breathnach, and S. Krishna. 2008. Diagnosis of Clostridium difficile infection by toxin detection kits: a systematic review. Lancet Infect. Dis. 8:777-784.
10. Sharp, S., L. O. Ruden, J. C. Pohl, P. A. Hatcher, L. M. Jayne, and W. M. Ivie. 2010. Evaluation of the C.Diff Quik Chek Complete assay, a new glutamate dehydrogenase and A/B toxin combination lateral flow assay for use in rapid, simple diagnosis of Clostridium difficile disease. J. Clin. Microbiol. 48:2082-2086.
11. Swindells, J., N. Brenwald, N. Reading, and B. Oppenheim. 2010. Evaluation of diagnostic tests for Clostridium difficile infection. J. Clin. Microbiol. 48:606-608.