Metalation of 2-heterosubstituted naphthalenes at the 1- or 3- position: Factors that may determine the regiochemistry

Synthesis

Volumn , Issue 9, 2010, Pages 1531-1535

  Ruzziconi, Renzo ^a   Spizzichino, Sara ^a   Giurg, Miroslav ^b   Castagnetti, Eva ^b   Schlosser, Manfred ^b  

^a Chemistry Department University   (Italy)

^b EPFL   (Switzerland)

Author keywords

2 (tri fluoromethoxy)naphthalene; 2 fluoronaphthalene; 2 methoxynaphthalene; Regioselective metalation; Substituent effects

Indexed keywords

2-METHOXYNAPHTHALENE; LITHIUM ATOMS; METALATIONS; METHOXY GROUP; REGIOCHEMISTRY; REGIOISOMERIC MIXTURES; REGIOSELECTIVE METALATION; STERIC REPULSIONS; SUBSTITUENT EFFECT; TRIFLUOROMETHYL;

LITHIUM; REGIOSELECTIVITY;

NAPHTHALENE;

2 (TRIFLUOROMETHOXY)NAPHTHALENE; 2 (TRIFLUOROMETHYL)NAPHTHALENE; 2 FLUORONAPHTHALENE; 2 METHOXYNAPHTHALENE; HYDROGEN; LITHIUM; NAPHTHALENE; NAPHTHALENE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; ELECTROPHILICITY; METALATION; PROTON TRANSPORT; SYNTHESIS;

EID: 77955460487     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/S-0029-1218737     Document Type: Article

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