The effect of local use of nandrolone decanoate on rotator cuff repair in rabbits

Journal of Investigative Surgery

Volumn 23, Issue 4, 2010, Pages 204-207

  Papaspiliopoulos, Athanasios ^a   Papaparaskeva, Kleo ^a   Papadopoulou, Eleni ^b   Feroussis, John ^a   Papalois, Apostolos ^c   Zoubos, Aristedes ^d  

^a IASO GENERAL HOSPITAL   (Greece)

^b NATIONAL TECHNICAL UNIVERSITY OF ATHENS   (Greece)

^c UNIVERSITY OF PATRAS   (Greece)

^d NATIONAL AND KAPODISTRIAN UNIVERSITY OF ATHENS   (Greece)

Author keywords

Anabolic steroids; Drug abuse; Nandrolone decanoate; Rotator cuff repair; Tendon healing; Tendon injury

Indexed keywords

NANDROLONE DECANOATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOMECHANICS; CONTROLLED STUDY; FIBROBLAST; HEALING; HISTOPATHOLOGY; IMMOBILIZATION; INFLAMMATION; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; ROTATOR CUFF INJURY; TENDON RECONSTRUCTION;

ANABOLIC AGENTS; ANIMALS; BIOMECHANICS; MALE; MODELS, ANIMAL; NANDROLONE; RABBITS; RECOVERY OF FUNCTION; RESTRAINT, PHYSICAL; ROTATOR CUFF; TENDONS; WOUND HEALING;

EID: 77955451052     PISSN: 08941939     EISSN: 15210553     Source Type: Journal    
DOI: 10.3109/08941939.2010.481007     Document Type: Article

References (42)

1. David HG, Green JT, Grant AJ, et al. Simultaneous bilateral quadriceps rupture: a complication of anabolic steroid abuse. J Bone Joint Surg Br. 1995;77-B:159-160
2. Lewis AC, Purushotham B, Power DM. Bilateral simultaneous quadriceps tendon rupture in a bodybuilder. Orthopedics. 2005;28(7):701-702.
3. Isenberg J, Prokop A, Skouras E. Successive ruptures of patellar and Achilles tendons: anabolic steroids in competitive sports. Unfallchirurg. 2008;111(1):46-49
4. Hill JA, Suker JR, Sachs K, et al. The athletic polydrug abuse phenomenon: a case report. Am J Sports Med. 1983;11:269-271
5. Visuri T, Lindholm H. Bilateral distal biceps tendon avulsions with use of anabolic steroids. Med Sci Sports Exerc.1994;26(8):941-944
6. Pärssinen M, Karila T, Kovanen V, et al. The effect of supraphysiological doses of anabolic androgenic steroids on collagen metabolism. Int J Sports Med. 2000;21:406-411.
7. Lasseter JT, Russell JA. Anabolic steroid-induced tendon pathology: a review of the literature. Med Sci Sports Exerc. 1991;23:1-3.
8. Evans NA, Bowrey DJ, Newman GR. Ultra structural analysis of ruptured tendon from anabolic steroid users. Injury. 1998;29:769-773
9. Miles JW, GranaWA, Egle D, et al. The effect of anabolic steroids on the biomechanical and histological properties of rat tendon. J Bone Joint Surg Am. 1992;74:411-422.
10. Mottram DR, George AJ. Anabolic steroids. Baillieres Best Pract Res Clin Endocrinol Metab. 2000;14:55-69
11. Karpakka JA, Pesola MK, Takala TE. The effects of anabolic steroids on collagen synthesis in rat skeletal muscle and tendon. Am J Sports Med. 1992;20:262-265.
12. Michna H. Tendon injuries induced by exercise and anabolic steroids in experimental mice. Int Orthop. 1987;11:157-162.
13. Wood TO, Cooke PH, Goodship AE. The effect of exercise and anabolic steroids on the mechanical properties and crimp morphology of the rat tendon. Am. J. Sports Med. 1988;16:153-158.
14. Clayton RA, Court-Brown CM. The epidemiology of musculoskeletal tendinous and ligamentous injuries. Injury. 2008;39(12):1338-1344.
15. Löhr JF, Uhthoff HK. Epidemiology and pathophysiology of rotator cuff tears. Orthopade. 2007;36(9):788-795.
16. Sørensen AK, Bak K, Krarup AL, et al. Acute rotator cuff tear: do we miss the early diagnosis? A prospective study showing a high incidence of rotator cuff tears after shoulder trauma. J Shoulder Elbow Surg. 2007;16(2):174-180.
17. Gerber C, Fuchs B, Hodler J. The results of repair of massive tears of the rotator cuff. J Bone Joint Surg Am. 2000;82:505-515.
18. Iannotti JP, Bernot MP, Kuhlman JR, et al. Postoperative assessment of shoulder function: a prospective study of full-thickness rotator cuff tears. J Shoulder Elbow Surg. 1996;5:449-457.
19. Cadet ER, Hsu JW, Levine WN, et al. The relationship between greater tuberosity osteopenia and the chronicity of rotator cuff tears. J Shoulder Elbow Surg. 2008;17(1):73-77.
20. Oh JH, Kim SH, Ji HM, et al. Prognostic factors affecting anatomic outcome of rotator cuff repair and correlation with functional outcome. Arthroscopy. 2009;25(1):30-39.
21. Gladstone JN, Bishop JY, Lo IK, et al. Fatty infiltration and atrophy of the rotator cuff do not improve after rotator cuff repair and correlate with poor functional outcome. Am J Sports Med. 2007;35(5):719-728.
22. Burkhart SS, Danacau SM, Pearce CE Jr. Arthroscopic rotator cuff repair: analysis of results by tear size and by repair technique-margin convergence versus direct tendon-to-bone repair. Arthroscopy. 2001;17:905-912.
23. Sugaya H, Maeda K, Matsuki K, et al. Repair integrity and functional outcome after arthroscopic double-row rotator cuff repair. A prospective outcome study. J Bone Joint Surg Am. 2007;89(5):953-960.
24. Scheibel M, Brown A, Woertler K, et al. Preliminary results after rotator cuff reconstruction augmented with an autologous periosteal flap. Knee Surg Sports Traumatol Arthrosc. 2007;15(3):305-314.
25. Miniaci A, MacLeod M. Transfer of the latissimus dorsi muscle after failed repair of a massive tear of the rotator cuff: a two-to five-year review. J Bone Joint Surg Am. 1999;81:1120-1127.
26. Warner JJ, Parsons IM IV. Latissimus dorsi tendon transfer: a comparative analysis of primary and salvage reconstruction of massive, irreparable rotator cuff tears. J Shoulder Elbow Surg. 2001;10:514-521.
27. Iannotti JP, Hennigan S, Herzog R, et al. Latissimus dorsi tendon transfer for irreparable posterosuperior rotator cuff tears. Factors affecting outcome. J Bone Joint Surg Am. 2006;88: 342-348.
28. Triantafillopoulos IK, Banes AJ, Bowman KF Jr, et al. Nandrolone decanoate and load increase remodeling and strength in human supraspinatus bioartificial tendons.Am. J. SportsMed. 2004;4:934-943.
29. Demling RH, Orgill DP. The anticatabolic and wound healing effects of the testosterone analog oxandrolone after severe burn injury. J Crit Care. 2000;15:12-17.
30. MacGillivray MH, Kolotkin M, Munschauer RW. Enhanced linear growth responses in hypopituitary dwarfs treated with growth hormone plus androgen versus growth hormone alone. Pediatr Res. 1974;8:103-108.
31. Hervey GR, Knibbs AV, Burkinshaw L, et al. Effects of methandienone on the performance and body composition of men undergoing athletic training. Clin Sci (Lond). 1981;60:457-461.
32. Frankle MA, Leffers D. Anabolic androgenic steroids: a guide for the orthopaedic surgeon. Orthopaedic Perspectives. 1990;1(1):119-140
33. Hart DW, Wolf SE, Ramzy PI, et al. Anabolic effects of oxandrolone after severe burn. Ann Surg. 2001;233:556-564.
34. Riemersa DJ, Schamhardt HC. The Cryo-Jaw.Aclamp designed for in vitro rheology studies of horse digital flexor tendons. J. Biommiech. 1982;15:619-620.
35. Rickert M, Georgousis H, Witzel U. Tensile strength of the tendon of the supraspinatusmuscle in the human.Abiomechanical study. Unfallchirurg. 1999;102(1):77-78.
36. Evans NA. Current concepts in anabolic-androgenic steroids. Am. J. Sports Med. 2004;32:534-542
37. Riley GP, Curry V, Degroot J, et al. Matrix metalloproteinase activities and their relationship with collagen remodeling in tendon pathology. Matrix Biol. 2002;21:185-195.
38. Kjaer M. Role of extracellular matrix in adaptation of tendon and skeletal muscle to mechanical loading. Physiol Rev. 2004;84:649-698.
39. Inhofe PD, Grana WA, Egle D, et al. The effect of anabolic steroids on rat tendon: an ultrastructural, biomechanical, and biochemical analysis. Am J Sports Med. 1995;23:227-232.
40. Evans NA. Anabolic steroids and the orthopaedic surgeon. J Bone Joint Surg Br. 1998;80-B(suppl 1):49.
41. RileyGP. Gene expression andmatrix turnover in overused and damaged tendons. Scand J Med Sci Sports. 2005;15:241-251.
42. Marqueti RC, Parizotto NA, Chriguer RS, et al. Androgenicanabolic steroids associated with mechanical loading inhibit matrix metallopeptidase activity and affect the remodeling of the achilles tendon in rats. Am J Sports Med.2006;34:1274-1280.