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Ruperto N, Murray KJ, Gerloni V, et al.: A randomized trial of parenteral methotrexate in intermediate versus higher doses in children with juvenile idiopathic arthritis who failed standard dose. Arthritis Rheum 2004, in press. This is the first PRINTO international trial with 595 patients enrolled from 20 countries that led to the establishment of the maximum dose and way of administration of MTX that should be administered to children with JIA. Of note, the trial has been conducted only with public funding from the European Union, with no pharmaceutical company support.
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