The danger of sedenterism: Endothelium at risk

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 299, Issue 2, 2010, Pages

  Widlansky, Michael E ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1;

CALORIC INTAKE; CARDIOVASCULAR RISK; DYSLIPIDEMIA; EDITORIAL; ENDOTHELIAL DYSFUNCTION; HUMAN; HYPERTENSION; IMMOBILIZATION; INFLAMMATION; INSULIN RESISTANCE; IONTOPHORESIS; LASER DOPPLER FLOWMETRY; OBESITY; PRIORITY JOURNAL; SEDENTERISM; SHEAR STRESS;

BIOLOGICAL MARKERS; BLOOD GLUCOSE; CELL-DERIVED MICROPARTICLES; E-SELECTIN; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; HUMANS; LEG; LIPIDS; MICROCIRCULATION; SEDENTARY LIFESTYLE; SKIN; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASODILATION;

EID: 77955444080     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00505.2010     Document Type: Editorial

References (13)

1. Bleeker MW, De Groot PC, Rongen GA, Rittweger J, Felsenberg D, Smits P, Hopman MT. Vascular adaptation to deconditioning and the effect of an exercise countermeasure: results of the Berlin Bed Rest study. J Appl Physiol 99: 1293-1300, 2005.
2. Boulanger CM, Amabile N, Tedgui A. Circulating microparticles: a potential prognostic marker for atherosclerotic vascular disease. Hypertension 48: 180-186, 2006.
3. Centers for Disease Control and Prevention. 2010 U.S. Physical Activity Statistics. http://apps.nccd.cdc.gov/PASurveillance/DemoComparev. asp.
4. Colditz GA. Economic costs of obesity and inactivity. Med Sci Sports Exerc 31: S663-S667, 1999.
5. Demiot C, Dignat-George F, Fortrat JO, Sabatier F, Gharib C, Larina I, Gauquelin-Koch G, Hughson R, Custaud MA. WISE 2005: chronic bed rest impairs microcirculatory endothelium in women. Am J Physiol Heart Circ Physiol 293: H3159-H3164, 2007.
6. George FD. Microparticles in vascular diseases. Thromb Res 122, Suppl 1: S55-S59, 2008.
7. Hamburg NM, McMackin CJ, Huang AL, Shenouda SM, Widlansky ME, Schulz E, Gokce N, Ruderman NB, Keaney JF Jr, Vita JA. Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers. Arterioscler Thromb Vasc Biol 27: 2650-2656, 2007.
8. Hesse C, Siedler H, Luntz SP, Arendt BM, Goerlich R, Fricker R, Heer M, Haefeli WE. Modulation of endothelial and smooth muscle function by bed rest and hypoenergetic, low-fat nutrition. J Appl Physiol 99: 2196-2203, 2005.
9. Navasiolava NM, Dignat-George F, Sabatier F, Larina IM, Demiot C, Fortrat JO, Gauquelin-Koch G, Kozlovskaya IB, Custaud MA. Enforced physical inactivity increases endothelial microparticle levels in healthy volunteers. Am J Physiol Heart Circ Physiol (May 14, 2010). doi:10.1152/ajpheart.00152.2010.
10. Pratt M, Macera CA, Wang G. Higher direct medical costs associated with physical inactivity. Phys Sportsmed 28: 63-70, 2000.
11. Shoemaker JK, Hogeman CS, Silber DH, Gray K, Herr M, Sinoway LI. Head-down-tilt bed rest alters forearm vasodilator and vasoconstrictor responses. J Appl Physiol 84: 1756-1762, 1998.
12. Stuart CA, Shangraw RE, Prince MJ, Peters EJ, Wolfe RR. Bed-rest-induced insulin resistance occurs primarily in muscle. Metabolism 37: 802-806, 1988.
13. Widlansky ME, Gokce N, Keaney JF Jr, Vita JA. The clinical implications of endothelial dysfunction. J Am Coll Cardiol 42: 1149-1160, 2003.