Synthesis of potent chemical inhibitors of dynamin GTPase

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 16, 2010, Pages 4858-4864

  Lee, Suho ^a,b   Jung, Kwan Young ^a   Park, Joohyun ^b   Cho, Joong Heui ^a   Kim, Yong Chul ^a   Chang, Sunghoe ^b  

^a Gwangju Institute of Science and Technology (GIST)   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Clathrin; Dynamin; Dynasore; Endocytosis; GTPase; Transferrin

Indexed keywords

DYNAMIN; DYNASORE; ENZYME INHIBITOR; TRANSFERRIN; UNCLASSIFIED DRUG; CLATHRIN; DD-11 COMPOUND; DD-6 COMPOUND; HYDRAZONE DERIVATIVE; N'-(3,4-DIHYDROXYBENZYLIDENE)-3-HYDROXY-2-NAPHTHAHYDRAZIDE;

ARTICLE; CHEMICAL REACTION; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; MICROSCOPY; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; CHLOROCEBUS AETHIOPS; COS 1 CELL LINE; ENDOCYTOSIS; METABOLISM; SYNTHESIS;

ANIMALS; CERCOPITHECUS AETHIOPS; CLATHRIN; COS CELLS; DYNAMINS; ENDOCYTOSIS; ENZYME INHIBITORS; HYDRAZONES; TRANSFERRIN;

EID: 77955427597     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.06.092     Document Type: Article

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15. 3/MeOH, 20:1) to afford the product as solid (DD-4-11).
16. 3/MeOH, 20:1) to afford the product as solid (DD-12-19).
17. 6. Unless otherwise noted, chemical shifts are expressed as ppm downfield from internal tetramethylsilane, or relative ppm from NMR solvent. Data are reported as follows: chemical shift, multiplicity (s, singlet; d, doublet; t, triplet; m, multiplet; b, broad; app., apparent), coupling constants, and integration. Mass spectroscopy was carried out on MALDI-TOF and LC-MS instruments.
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