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Volumn 878, Issue 24, 2010, Pages 2217-2225
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Chromatographic separation and sensitive determination of teriflunomide, an active metabolite of leflunomide in human plasma by liquid chromatography-tandem mass spectrometry
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Author keywords
Bioequivalence study; Human plasma; LC ESI MS MS; Teriflunomide
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Indexed keywords
ACTIVE METABOLITES;
AMMONIUM ACETATE;
ANALYTICAL COLUMNS;
BIOEQUIVALENCE STUDY;
CHROMATOGRAPHIC SEPARATIONS;
CONCENTRATION RANGES;
ETHYL ACETATES;
HIGH THROUGHPUT;
HUMAN PLASMAS;
INTERNAL STANDARDS;
ION TRANSITION;
ISOCRATIC MOBILE PHASE;
LC-ESI-MS/MS;
LEFLUNOMIDE;
LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY;
LIQUID-LIQUID EXTRACTION;
MATRIX EFFECTS;
MULTIPLE REACTION MONITORING;
PLASMA SAMPLES;
POST-COLUMN;
PROCESS EFFICIENCY;
RUNTIMES;
TABLET FORMULATIONS;
TRIPLE-QUADRUPOLE MASS SPECTROMETER;
VALSARTAN;
AMMONIUM COMPOUNDS;
CHROMATOGRAPHY;
ESTERS;
HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;
HIGH PRESSURE LIQUID CHROMATOGRAPHY;
LIQUIDS;
MASS SPECTROMETRY;
METABOLISM;
METABOLITES;
METHANOL;
PLASMA (HUMAN);
SOLVENT EXTRACTION;
PLASMAS;
AMMONIUM ACETATE;
LEFLUNOMIDE;
METHANOL;
TERIFLUNOMIDE;
VALSARTAN;
ADULT;
ARTICLE;
BIOEQUIVALENCE;
CONTROLLED STUDY;
DRUG DETERMINATION;
DRUG FORMULATION;
DRUG STABILITY;
ELECTROSPRAY MASS SPECTROMETRY;
FEMALE;
FLOW RATE;
HUMAN;
LIQUID CHROMATOGRAPHY;
LIQUID LIQUID EXTRACTION;
MALE;
NORMAL HUMAN;
PRIORITY JOURNAL;
TANDEM MASS SPECTROMETRY;
ACETATES;
ADULT;
CHROMATOGRAPHY, LIQUID;
CROTONIC ACIDS;
DRUG STABILITY;
HIGH-THROUGHPUT SCREENING ASSAYS;
HUMANS;
ISOXAZOLES;
LEAST-SQUARES ANALYSIS;
MALE;
MIDDLE AGED;
REPRODUCIBILITY OF RESULTS;
SENSITIVITY AND SPECIFICITY;
SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;
TANDEM MASS SPECTROMETRY;
THERAPEUTIC EQUIVALENCY;
TOLUIDINES;
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EID: 77955425204
PISSN: 15700232
EISSN: None
Source Type: Journal
DOI: 10.1016/j.jchromb.2010.06.028 Document Type: Article |
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Times cited : (34)
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References (20)
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