Ectopic and heterotopic pregnancies following in vitro fertilization

Infertility and Assisted Reproduction

Volumn , Issue , 2008, Pages 619-628

  Hubayter, Ziad R ^a   Muasher, Suheil J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 77955423750     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1017/CBO9780511547287.066     Document Type: Chapter

References (87)

1. Barbieri RL, Hornstein MD. Assisted reproduction. In: Strauss JF, Barbieri RL, eds. Yen and Jaffe̕s Reproductive Endocrinology. Fifth edn. Elsevier Saunders, Philadelphia, 2004: 839-73.
2. Ectopic pregnancy -- United States, 1990-1992. MMWR Morb Mortal Wkly Rep 1995; 44: 46-8.
3. Rizk B, Tan SL, Morcos S, et al. Heterotopic pregnancies following in-vitro fertilization and embryo transfer. Am J Obstet Gynecol. 1991; 164(1): 161-4.
4. Abusheikha N, Marcus SF. Ectopic pregnancy following assisted reproductive technology. In: Brinsden PR, ed. A Textbook of In Vitro Fertilization and Assisted Reproduction. The Bourn Hall Guide to Clinical and Laboratory Practice, second edn. The Parthenon Publishing Group Inc., Pearl River, 1999: 333-42.
5. Jain A, Solima E, Luciano AA. Ectopic pregnancy. J Am Assoc Gynecol Laparosc 1997; 4: 513-31.
6. Department of Health and Human Services. CDC. 2002 Assisted Reproductive Technology (ART) Report, 2002. (Accessed December 1, 2006, at http://www.cdc.gov/ART/ART02/index.htm).
7. Rizk B, Morcos S, Avery S, et al. Rare ectopic pregnancies after in-vitro fertilization: one unilateral twin and four bilateral tubal pregnancies. Hum Reprod 1990; 5(8): 1025-28.
8. Rizk B, Lachelin GCL, Davies MC, et al. Ovarian pregnancy following in-vitro fertilization and embryo transfer. Hum Reprod 1990; 5(6): 763-4.
9. Dimitry ES, Rizk B. Ectopic pregnancy: epidemiology, advances in diagnosis and management. Brit J Clin Pract 1992; 46(1): 52-4.
10. Xiao HM, Gong F, Mao ZH, Zhang H, Lu GX. Analysis of 92 ectopic pregnancy patients after in vitro fertilization and embryo transfer. Zhong Nan Da Xue Xue Bao Yi Xue Ban 2006; 31: 584-7.
11. Cohen J, Mayaux MF, Guihard-Moscato ML, Schwartz D. In vitro fertilization and embryo transfer: a collaborative study of 1163 pregnancies on the incidence and risk factors of ectopic pregnancies. Hum Reprod 1986; 1: 255-8.
12. Seeber BE, Barnhart KT. Suspected ectopic pregnancy. Obstet Gynecol 2006; 107: 399-413.
13. Tal J, Haddad S, Gordon N, Timor-Tritsch I. Heterotopic pregnancy after ovulation induction and assisted reproductive technologies: a literature review from 1971 to 1993. Fertil Steril 1996; 66: 1-12.
14. Lau S, Tulandi T. Conservative medical and surgical management of interstitial ectopic pregnancy. Fertil Steril 1999; 72: 207-15.
15. Bouyer J, Coste J, Shojaei T, et al. Risk factors for ectopic pregnancy: a comprehensive analysis based on a large case-control, population based study in France. Am J Epidemiol 2003; 157: 185-94.
16. Gemzell C, Guillome J, Wang CF. Ectopic pregnancy following treatment with human chorionic gonadotropins. Am J Obstet Gynecol 1982; 143: 761-5.
17. Clayton HB, Schieve LA, Peterson HB, Jamieson DJ, Reynolds MA, Wright VC. Ectopic pregnancy risk with assisted reproductive technology procedures. Obstet Gynecol 2006; 107: 595-604.
18. Jun SH, Milki AA. Assisted hatching is associated with a higher ectopic pregnancy rate. Fertil Steril 2004; 81: 1701-3.
19. Strandell A, Thorburn J, Hamberger L. Risk factors for ectopic pregnancy in assisted reproduction. Fertil Steril 1999; 71: 282-6.
20. Dumesic DA, Damario MA, Session DR. Interstitial heterotopic pregnancy in a woman conceiving by in vitro fertilization after bilateral salpingectomy. Mayo Clin Proc 2001; 76: 90-2.
21. Yovich JL, Turner S, Murphy A. Embryo transfer technique as a cause of ectopic pregnancies in in vitro fertilization. Fertil Steril 1985; 44: 318-21.
22. Knutzen V, Stratton CJ, Shee G, McNamee PI, Huang TT, Soto- Albors C. Mock embryo transfer in early luteal phase, the cycle before in vitro fertilization and embryo transfer: a descriptive study. Fertil Steril 1992; 57: 156-62.
23. Marcus S, Brinsden P. Analysis of the incidence and risk factors associated with ectopic pregnancy following in vitro fertilization embryo transfer. Hum Reprod 1995; 10: 199-203.
24. Milki AA, Jun SH. Ectopic pregnancy rates with day 3 versus day 5 embryo transfer: a retrospective analysis. BMC Pregnancy Childbirth 2003; 3: 7.
25. Dor J, Seidman DS, Levran D, Ben-Rafael, Ben-Shlomo I, Mashiach S. The incidence of combined intrauterine and extrauterine pregnancy after in vitro fertilization and embryo transfer. Fertil Steril 1991; 55: 833-4.
26. Rizk B, Dimitry ES, Morcos S, Edwards RG, et al.Amulticenter study on combined intrauterine and extrauterine pregnancy after IVF. 2nd joint meeting of ESHRE and European Sterility Congress Organization, Milan, Italy. August. Reproduction 1990; Abstract No. 377: 113-4.
27. Rizk B, Tan SL, Riddle A, et al. Heterotopic pregnancy and IVF. British Fertility Society Annual Meeting, The London Hospital, London, England, 1989.
28. Tang OS, Ng EH, So WW, Ho PC. Ultrasound-guided embryo transfer: a prospective randomized controlled trial. Hum Reprod 2001; 16: 2310-15.
29. Sallam HN, Sadek SS. Ultrasound-guided embryo transfer: a meta-analysis of randomized controlled trials. Fertil Steril 2003; 80: 1042-6.
30. Bouyer J, Coste J, Fernandez H, et al. Sites of ectopic pregnancy: a 10 year population based study of 1800 cases. Hum Reprod 2002; 17: 3224-30.
31. Comstock C, Huston K, Lee W. The ultrasonographic appearance of ovarian ectopic pregnancies. Obstet Gynecol 2005; 105: 42-45.
32. Martin JN Jr., Sessums JK, Marin RW, et al. Abdominal pregnancy: current concepts of management. Obstet Gynecol 1988; 71: 549-57.
33. Maymon R, Halperin R, Mendlovic S. Ectopic pregnancies in Caesarean section scars: the 8 year experience of one medical centre. Hum Reprod 2004; 19: 278-84.
34. Pisarska MD, Carson SA, et al. Ectopic pregnancy. Lancet 1998; 351: 1115-20.
35. Job-Spira N, Fernandez H, Bouyer J, et al. Ruptured tubal ectopic pregnancy: risk factors and reproductive outcome: results of a population-based study in France. Am J Obstet Gynecol 1999; 180: 938-44.
36. Kadar N, Caldwell BV, Romero R. A method of screening for ectopic pregnancy and its indications. Obstet Gynecol 1981; 58: 162-6.
37. Barnhart K, Sammel MD, Rinaudo PF, Zhou L, Hummel AC, Guo W. Symptomatic patients with an early viable intrauterine pregnancy: hCG curves redefined. Obstet Gynecol 2004; 104: 50-5.
38. Barnhart K, Sammel MD, Chung K, Zhou L, Hummel AC, Guo W. Decline of serum human chorionic gonadotropin and spontaneous complete abortion: defining the normal curve. Obstet Gynecol 2004; 104: 975-81.
39. Glastein IZ, Hornstein MD, Kahana MJ, et al. The predictive value of discriminatory human chorionic gonadotropin levels in the diagnosis of implantation outcome in in vitro fertilization cycles. Fertil Steril 1995; 63: 350-6.
40. Mol BW, Veen VF, Hajenius JP, et al. Diagnosis of ectopic pregnancy after in vitro fertilization and embryo transfer. Fertil Steril 1997; 68: 1027-32.
41. Chen CD, Ho HN, Wu MY, Chao KH, Chen SU, Yang YS. Paired human chorionic gonadotropin determination for the prediction of pregnancy outcome in assisted reproduction. Hum Reprod 12: 2538-41.
42. Rizk B, Marcus S, Fountain S, et al. The value of transvaginal sonography and hCG in the diagnosis of heterotopic pregnancy. 9th Annual meeting of the ESHRE, Thessaloniki, June. Hum Reprod 1993; Abstract No. 102.
43. Levi CS, Lyons EA, Lindsay DJ. Ultrasound in the first trimester. Radiol Clin North Am 1990; 28: 19-38.
44. Tongsong T, Pongsatha S. Transvaginal sonographic features in diagnosis of ectopic pregnancy. Int J Gynaecol Obstet 1993; 43: 277-83.
45. Brown DL, Doubilet PM. Transvaginal sonography for diagnosing ectopic pregnancy: positivity criteria and performance characteristics. J Ultrasound Med 1994; 13: 259-66.
46. Pellerito JS, Taylor KJ, Quedens-case C, et al. Ectopic pregnancy: evaluation with endovaginal color flow imaging. Radiology 1992; 183: 407-11.
47. Kirchler HC, Seebarcher S, Alge AA, Muller-Holzner E, Fessler S, Kolle D. Obstet Gynecol 1993; 82: 561-5.
48. Condous G, Okaro E, Khalid A, et al. The accuracy of transvaginal ultrasonography for the diagnosis of ectopic pregnancy prior to surgery. Fertil Steril 2005; 20: 1404-9.
49. Fernandez H, Gervaise A. Ectopic pregnancies after infertility treatment: modern diagnosis and therapeutic strategy. Hum Reprod Update 2004; 10: 503-13.
50. Bassil S, Gordts S, Nisolle M, Van Beers B, Donnez J. A magnetic resonance imaging approach for the diagnosis of a triplet corneal pregnancy. Fertil Steril 1995; 64(5): 1029-31.
51. Ginsburg ES, Frates MC, Rein MS, Fox JH, Hornstein MD, Friedman AJ. Early diagnosis and treatment of cervical pregnancy in an in vitro fertilization program. Fertil Steril 1994; 61: 966-9.
52. Kataoka ML, Togashi K, Kobayashi H, Inoue T, Fuji S, Konishi J. Evaluation of ectopic pregnancy by magnetic resonance imaging. Hum Reprod 1999; 14: 2644-50.
53. Takeuchi K, Yamada T, Oomori S, Ideta K, Moriyama T, Maruo T. Comparison of magnetic resonance imaging and ultrasonography in the early diagnosis of interstitial pregnancy. J Reprod Med 1999; 44: 265-8.
54. Izquierdo LA, Nicholas MC. Three-dimensional transvaginal sonography of interstitial pregnancy. J Clin Ultrasound 2003; 31: 484-7.
55. Ioannidis G, Sacks G, Reddy N, et al. Day 14 maternal serum progesterone levels predict pregnancy outcome in IVF/ICSI treatment cycles: a prospective study. Hum Reprod 2005; 20: 741-6.
56. Mol BW, Lijmer JG, Ankum WM, et al. The accuracy of single serum progesterone measurement in the diagnosis of ectopic pregnancy: a meta-analysis. Hum Reprod 1998; 13: 3220-7.
57. McCord ML, Muram D, Buster JE, et al. Single serum progesterone as a screen for ectopic pregnancy: exchanging specificity and sensitivity to obtain optimal test performance. Fertil Steril 1996; 66: 513-16.
58. Daniel Y, Geva E, Lerner-Geva L, et al. Levels of vascular endothelial growth factor are elevated in patients with ectopic pregnancy: is this a novel marker? Fertil Steril 1999; 72: 1013-17.
59. Fasouliotis SJ, Spandorfer SD, Witkin SS, Liu HC, Roberts JE, Rosenwaks Z. Maternal serum vascular endothelial growth factor levels in early ectopic and intrauterine pregnancies after in vitro fertilization treatment. Feril Steril 2004; 82: 309-13.
60. Saha PK, Gupta I, Ganguly NK. Evaluation of serum creatine kinase as a diagnostic marker for tubal pregnancy. Aust NZ J Obstet Gynaecol 1999; 39: 366-7.
61. Lipscomb GH, Bran D, McCord ML, Portera JC, Ling FW. Analysis of three hundred fifteen ectopic pregnancies treated with single-dose methotrexate. Am J Obstet Gynecol 1998; 178: 1354-8.
62. Lipscomb GH, Givens VA, Meyer NL, Bran D. Previous ectopic pregnancy as a predictor of failure of systemic methotrexate therapy. Fertil Steril 2004; 81: 1221-4.
63. Lipscomb GH, McCord ML, Stovall TG, Huff G, Portera G, Ling FW. Predictors of success of methotrexate treatment in women with tubal ectopic pregnancies. N Engl J Med 1999; 341: 1974-8.
64. Bixby S, Tello R, Kuligowska E. Presence of yolk sac on transvaginal sonography is the most reliable predictor of single-dose methotrexate treatment failure in ectopic pregnancy. J Ultrasound Med 2005; 24: 591-8.
65. Sowter MC, Farquhar CM, Petrie KJ, Gudex G. A randomised trial comparing single dose systemic methotrexate and laparoscopic surgery for the treatment of unruptured tubal pregnancy. Br J Obstet Gynecol 2001; 108: 192-203.
66. Sowter MC, Farquhar CM, Gudex G. An economic evaluation of single dose systemic methotrexate and laparoscopic surgery for the treatment of unruptured ectopic pregnancy. Br J Obstet Gynecol 2001; 108: 204-12.
67. Medical management of tubal pregnancy. ACOG Practice bulletin #3. American College of Obstetricians and Gynecologists, 1998.
68. Barnhart KT, Gosman G, Ashby R, Sammel M. The medical management of ectopic pregnancy: a meta-analysis comparing “single dose” and “multidose” regimens. Obstet Gynecol 2003; 101: 778-84.
69. Alleyassin A, Khademi A, Aghahosseini M, Safdarian L, Badenoosh B, Hamed EA. Comparison of success rates in the medical management of ectopic pregnancy with single dose and multiple dose administration of methotrexate: a prospective, randomized clinical trial. Fertil Steril 2006; 85: 1661-6.
70. Lipscomb GH, Givens VM, Meyer NL, Bran D. Comparison of multidose and single dose methotrexate protocols for the treatment of ectopic pregnancy. Am J Obstet Gynecol 2005; 192: 1844-7.
71. Lipscomb GH, Meyer NL, Flynn DE, Peterson M, Ling FW. Oral methotrexate for treatment of ectopic pregnancy. Am J Obstet Gynecol 2002; 186: 1192-5.
72. Fernandez H, Benifla JL, Lelaidier C, Baton C, Frydman R. Methotrexate treatment of ectopic pregnancy: 100 cases treated by primary transvaginal injection under sonographic control. Fertil Steril 1993; 59: 773-7.
73. Fernandez H, Yves Vincent SC, Pauthier S, et al. Randomized trial of conservative laparoscopic treatment and methotrexate administration in ectopic pregnancy and subsequent fertility. Hum Reprod 1998; 13: 3239-43.
74. Tzafettas JM, Stephanatos A, Loufopoulos A, et al. Single high dose of local methotrexate for the management of relatively advanced ectopic pregnancies. Fertil Steril 1999; 71: 1010-13.
75. Oyawoye S, Chander B, Pavlovic B, Hunter J, Abdel Gadir A. Heterotopic pregnancy with aspiration of corneal/interstitial gestational sac and instillation of small dose of methotrexate. Fetal diagn ther 2003; 18: 1-4.
76. Rozenberg P, Chevret S, Camus E, et al. Medical treatment of ectopic pregnancies: a randomized clinical trial comparing methotrexate-mifepristone and methotrexate-placebo. Hum Reprod 2003; 18: 1802-8.
77. Lipscomb GH, Stovall TG, Ling FW. Nonsurgical treatment of ectopic pregnancy. N Engl J Med 2000; 343: 1325-9.
78. Murphy AA, Kettel LM, Nager CW, et al. Operative laparoscopy versus laparotomy for the management of ectopic pregnancy: a prospective trial. Fertil Steril 1992; 57: 1180-5.
79. Vermesh M, Silva PD, Rosen GF, et al. Management of unruptured ectopic gestation by linear salpingostomy: a prospective, randomized clinical trial of laparoscopy versus laparotomy. Obstet Gynecol 1989; 73: 400-4.
80. Hajenius PJ, Mol BW, Bossuyt PM, Ankum WM, Van Der Veen F. Interventions for tubal ectopic pregnancy. Cochrane Database Syst Rev 2000; (2):CD000324.
81. Silva PD, Schaper AM, Rooney B. Reproductive outcome after 143 laparoscopic procedures for ectopic pregnancy. Obstet Gynecol 1993; 81: 710-15.
82. Dubuisson JB, Morice P, Chapron C, De Gayffier A, Mouelhi T. Salpingectomy—the laparoscopic surgical choice for ectopic pregnancy. Hum Reprod 1996; 11: 1199-203.
83. Mueller MD. Ectopic pregnancy. In: Lebovic DI, Gordon JD, Taylor RN, Eds. Reproductive Endocrinology and Infertility -- Handbook for Clinicians. First edn. Scrub Hill Press, Inc., Arlington, 2005: 113-23.
84. Tulandi T. Surgical treatment of ectopic pregnancy and prognosis for subsequent fertility. In: Rose BD ed. UpToDate. Waltham, MA, 2006.
85. Trio D, Stoblet N, Picciolo C, et al. Prognostic factors for successful expectant management of ectopic pregnancy. Fertil Steril 1995; 63: 15-19.
86. Shalev E, Peleg D, Tsabari A, et al. Spontaneous resolution of ectopic tubal pregnancy: natural history. Fertil Steril 1995; 63: 469-72.
87. Lemus JF. Ectopic pregnancy: an update. Curr Opin Obstet Gynecol 2000; 12: 369-75.