Effects of storage on the biology and clinical efficacy of the banked red blood cell

Transfusion and Apheresis Science

Volumn 43, Issue 1, 2010, Pages 45-47

  Stowell, Christopher P ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIPHOSPHOGLYCERIC ACID; ADENOSINE TRIPHOSPHATE; HEMOGLOBIN; NITRIC OXIDE;

ANEMIA; BLOOD BANK; BLOOD CLOTTING TIME; BLOOD STORAGE; EDITORIAL; ERYTHROCYTE TRANSFUSION; HUMAN; INTENSIVE CARE; MICROCHIMERISM; MICROCIRCULATION; MICROVASCULARIZATION; OXYGEN SUPPLY; TISSUE OXYGENATION; TREATMENT OUTCOME;

BLOOD PRESERVATION; ERYTHROCYTES; HUMANS;

EID: 77955423712     PISSN: 14730502     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transci.2010.05.015     Document Type: Editorial

References (32)

1. Ohto H., Anderson K.C. Survey of transfusion-associated graft-versus-host disease in immunocompetent recipients. Transfus Med Rev 1996, 10:31-43.
2. Triulzi D.J., Duquesnoy R., Nichols L., Clark K., Jukic D., Zeevi A., et al. Fatal transfusion associated graft-versus-host disease in an immunocompetent recipient of a volunteer unit of red cells. Transfusion 2006, 46:885-888.
3. Lee T.H., Paglieroni T., Utter G.H., et al. High level long term, white blood cell microchimerism after transfusion of leukoreduced blood components to patients resuscitated after severe traumatic injury. Transfusion 2005, 45:702-707.
4. Vamvakas E.C., Blajchman M.A. Transfusion related immunomodultaion(TRIM): an update. Blood Rev 2007, 21:327-348.
5. Roback J.D., Su L., Zimring J.C., Hillyer C.D. Transfusion-transmitted cytomegalovirus: lessons from a murine model. Transfus Med Rev 2007 Jan, 21(1):26-36.
6. Young C., Krause P.J. The problem of transfusion-transmitted babesiosis. Transfusion 2009, 49(12):2548-2550.
7. Steiner M., Stowell C. Does red blood cell storage affect clinical outcome? When in doubt, do the experiment. Transfusion 2009, 49:1286-1290.
8. Bennett-Guerrero E., Veldman T.H., Doctor A., Telen M.J., Ortel T.L., Reid T.S., et al. Evolution of adverse changes in stored RBCs. Proc Natl Acad Sci. 2007, 104:17063-17068.
9. Kriebardis A.G., Antonelou M.H., Stamoulis K.E., Economou-Petersen E., Margaritis L.H., Papassideri I.S. Storage-dependent remodeling of the red blood cell membrane is associated with increased immunoglobulin G binding, lipid raft rearrangement, and caspase activation. Transfusion 2007, 47:1212-1220.
10. Greenwalt T.J. The how and why of exocytic vesicles. Transfusion 2006, 46:143-152.
11. Relevy H., Koshkaryev A., Manny N., Yedgar S., Barshtein G. Blood banking-induced alteration of red blood cell flow properties. Transfusion 2008, 48:136-146.
12. Morisaki H., Sibbald W. Tissue oxygen delivery and the microcirculation. Crit Care Clin 2004, 20:213-223.
13. Michelakis E. The role of the NO axis and its therapeutic implications in pulmonary arterial hypertension. Heart Fail Rev 2003, 8:5-21.
14. Hollenberg S.M., Cinel I. Bench-to-bedside review: nitric oxide in critical illness. Crit Care 2009, 13:218-226.
15. Gonzalez-Alonso J., Olsen D., Saltin B. Erythrocyte and the regulation of human skeletal muscle blood flow and oxygen delivery: role of circulating ATP. Circ Res 2002, 91:1046-1055.
16. Allen B., Piantadosi C. How do red blood cells cause hypoxic vasodilatation? The SNO-hemoglobin paradigm. Am J Physiol Heart Circ Physiol 2006, 291:H1507-H1512.
17. Cosby K., Partovi K., Crawford J., et al. Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med 2003, 9:1498-1505.
18. Spronk P., Zandstra D., Ince C. Bench-to-bedside review: Sepsis is a disease of the microcirculation. Crit Care 2004, 8:462-468.
19. Sakr Y., Dubois M.J., De Backer D., Creteur J., Vincent J.L. Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med 2004, 32:1825-1831.
20. Green D. A retrospective study of changes in cerebral oxygenation using a cerebral oximeter in older patients undergoing prolonged major abdominal surgery. Eur J Anaesthesiol 2007, 24:230-234.
21. Suttner S., Piper S., Kumle B., et al. The influence of allogeneic red blood cell transfusion compared with 100% oxygen ventilation on systemic oxygen transport and skeletal muscle oxygen tension after cardiac surgery. Anesth Analg 2004, 99:2-11.
22. Sakr Y., Chierego M., Piagnerelli M., et al. Microvascular response to red blood cell transfusion in patients with severe sepsis. Crit Care Med 2007, 35:1639-1644.
23. Kiraly L.N., Underwood S., Differding J.A., Schreiber M.A. Transfusion of aged packed red blood cells results in decreased tissue oxygenation in critically injured trauma patients. J Trauma 2009, 67:29-32.
24. Cabrales P., Intaglietta M., Tsai A. Transfusion restores blood viscosity and reinstates microvascular conditions from hemorrhagic shock independent of oxygen carrying capacity. Resuscitation 2007, 75:124-134.
25. Villela N.R., Cabrales P., Tsai A.G., Intaglietta M. Microcirculatory effects of changing blood hemoglobin oxygen affinity during hemorrhagic shock resuscitation in an experimental model. Shock 2009, 31:645-652.
26. Lelubre C., Piagnerelli M., Vincent J.L. Association between duration of storage of transfused red blood cells and morbidity and mortality in adult patients: myth or reality?. Transfusion 2009, 49:1384-1394.
27. Zimrin A.B., Hess J.R. Current issues relating to the transfusion of stored red blood cells. Vox Sang 2009, 96:93-103.
28. Vamvakas E.C. Meta-analysis of clinical studies of the purported deleterious effects of " old" (versus " fresh" ) red blood cells: are we at equipoise?. Transfusion 2010, 50:600-610.
29. Hébert P.C., Chin-Yee I., Fergusson D., et al. A pilot trial evaluating the clinical effects of prolonged storage of red cells. Anesth Analg 2005, 100:1433-1438.
30. Bennett-Guerrero E., Stafford-Smith M., Waweru P.M., Bredehoeft S.J., Campbell M.L., Haley R., Phillips-Bute B., Newman M.F., Bandarenko N. A prospective, double-blind, randomized clinical feasibility trial of controlling the storage age of red blood cells for transfusion in cardiac surgical patients. Transfusion 2009, 49:1375-1383.
31. Fergusson D., Hutton B., Hogan D.L., et al. The age of red blood cells in premature infants (ARIPI) randomized, controlled trial: study design. Transfus Med Rev 2009, 23:55-61.
32. The age of blood (ABLE) study. Available from: [accessed 03.11.10. http://www.controlled-trials.com/ISRCTN44878718/.