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Volumn 20, Issue 15, 2010, Pages 4496-4498

Antimalarial 3-arylamino-6-benzylamino-1,2,4,5-tetrazines

Author keywords

Malaria; Plasmodium falciparum; Tetrazines

Indexed keywords

ANTIMALARIAL AGENT; TETRAZINE DERIVATIVE; UNCLASSIFIED DRUG; WEHI 0033352; WEHI 0059743;

EID: 77955412820     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.06.036     Document Type: Article
Times cited : (25)

References (18)
  • 13
    • 84888471230 scopus 로고    scopus 로고
    • note
    • This was undertaken at the Swiss Tropical Research Institute. Compounds 1 and 2 belonged to primary screening hit sets derived from screening our high throughput screening library against Trypanosoma brucei-derived farnesyl pyrophosphate synthase (FPPS) and Trypanosoma cruzi-derived trypanothione reductase, respectively. The potent and selective antimalarial activity of compounds 1 and 2 was therefore serendipitous and may have arisen via mechanisms unrelated to the enzyme targets for the initial screen. We have recently disclosed the results of the trypanothione reductase high throughput screen (Ref. 17).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.