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This was undertaken at the Swiss Tropical Research Institute. Compounds 1 and 2 belonged to primary screening hit sets derived from screening our high throughput screening library against Trypanosoma brucei-derived farnesyl pyrophosphate synthase (FPPS) and Trypanosoma cruzi-derived trypanothione reductase, respectively. The potent and selective antimalarial activity of compounds 1 and 2 was therefore serendipitous and may have arisen via mechanisms unrelated to the enzyme targets for the initial screen. We have recently disclosed the results of the trypanothione reductase high throughput screen (Ref. 17).
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