Synthesis and cannabinoid-1 receptor binding affinity of conformationally constrained analogs of taranabant

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 16, 2010, Pages 4757-4761

  Kopka, Ihor E ^a   Lin, Linus S ^a   Jewell, James P ^a   Lanza, Thomas J ^a   Fong, Tung M ^a   Shen, Chun Pyn ^a   Lao, Zhege J ^a   Ha, Sookhee ^a   Castonguay, Laurie G ^a   Van Der Ploeg, Lex ^a   Goulet, Mark T ^a   Hagmann, William K ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Cannabinoid; CB1R; Conformationally constrained; Obesity

Indexed keywords

CANNABINOID 1 RECEPTOR; CANNABINOID 1 RECEPTOR AGONIST; TARANABANT; AMIDE; ANTIOBESITY AGENT; N-(3-(4-CHLOROPHENYL)-2-(3-CYANOPHENYL)-1-METHYLPROPYL)-2-METHYL-2-((5-(TRIFLUOROMETHYL)PYRIDIN-2-YL)OXY)PROPANAMIDE; PROTEIN BINDING; PYRIDINE DERIVATIVE;

ARTICLE; BINDING AFFINITY; DRUG CONFORMATION; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; MOLECULAR MODEL; NONHUMAN; OBESITY; PROTON NUCLEAR MAGNETIC RESONANCE; SEQUENCE HOMOLOGY; X RAY ANALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; CONFORMATION; HUMAN; METABOLISM; SYNTHESIS;

AMIDES; ANTI-OBESITY AGENTS; COMPUTER SIMULATION; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN BINDING; PYRIDINES; RECEPTOR, CANNABINOID, CB1;

EID: 77955412417     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.06.127     Document Type: Article

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