Stereospecific synthesis of (Z)-1,3-oxazolobenzimidazoles from imidazole- and benzene-ring-substituted benzimidazoles and α,β-acetylenic γ-hydroxynitriles

Synthesis

Volumn , Issue 16, 2010, Pages 2828-2834

  Andriyankova, Ludmila V ^a   Belyaeva, Kseniya V ^a   Nikitina, Lina P ^a   Malkina, Anastasiya G ^a   Afonin, Andrei V ^a   Trofimov, Boris A ^a  

^a A E FAVORSKY IRKUTSK INSTITUTE OF CHEMISTRY   (Russian Federation)

Author keywords

, acetylenic hydroxynitriles; 1,3 oxazolodihydrobenzimidazoles; annulations; substituted benzimidazoles; zwitterion intermediates

Indexed keywords

ACETYLENE CHEMISTRY; AROMATIC SYSTEM; BENZIMIDAZOLES; DRUG DESIGN; FACILE SYNTHESIS; ROOM TEMPERATURE; STEREOSPECIFIC; STEREOSPECIFIC SYNTHESIS; TARGET COMPOUND;

ACETONITRILE; ACETYLENE; BENZENE;

SYNTHESIS (CHEMICAL);

1,3 OXAZOLOBENZIMIDAZOLE DERIVATIVE; 2 [2,2,6,7,9 PENTAMETHYL 9,9A DIHYDRO[1,3]OXAZOLO[3,2 ALPHA]BENZIMIDAZOL 3(2H) YLIDEN]ACETONITRILE; 2 [2,2,9 TRIMETHYL 6 NITRO 9,9A DIHYDRO[1,3]OXAZOLO[3,2 ALPHA]BENZIMIDAZOL 3(2H) YLIDEN]ACETONITRILE; 2 [7 METHOXY 2,2,9 TRIMETHYL 9,9A DIHYDRO[1,3]OXAZOLO[3,2 ALPHA]BENZIMIDAZOL 3(2H) YLIDEN]ACETONITRILE; 2 [9 BENZYL 2,2,6,7 TETRAMETHYL 9,9A DIHYDRO[1,3]OXAZOLO[3,2 ALPHA]BENZIMIDAZOL 3(2H) YLIDEN]ACETONITRILE; 2 [9 BENZYL 6 NITRO 2,2 DIMETHYL 9,9A DIHYDRO[1,3]OXAZOLO[3,2 ALPHA]BENZIMIDAZOL 3(2H) YLIDEN]ACETONITRILE; 2 [9 BENZYL 7 METHOXY 2,2 DIMETHYL 9,9A DIHYDRO[1,3]OXAZOLO[3,2 ALPHA]BENZIMIDAZOL 3(2H) YLIDEN]ACETONITRILE; ACETONITRILE DERIVATIVE; ALPHA BETA ACETYLENIC GAMMA HYDROXY NITRILE DERIVATIVE; BENZIMIDAZOLE; BENZIMIDAZOLE DERIVATIVE; NITRILE; SPIRO 1,3 OXAZOLOBENZIMIDAZOLE; UNCLASSIFIED DRUG;

ANNULATION REACTION; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; DRUG DESIGN; REACTION TIME; STEREOSPECIFICITY; STRUCTURE ANALYSIS; SUBSTITUTION REACTION;

EID: 77955401364     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0030-1258152     Document Type: Article

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