A randomized double-blind, positive-control trial of topical thalidomide in erosive oral lichen planus

Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology

Volumn 110, Issue 2, 2010, Pages 188-195

  Wu, Yun ^a   Zhou, Gang ^b   Zeng, Hong ^c   Xiong, Chun Rong ^a   Lin, Mei ^b   Zhou, Hong Mei ^b  

^a SICHUAN UNIVERSITY   (China)

^b WUHAN UNIVERSITY   (China)

^c SICHUAN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; DEXAMETHASONE; IMMUNOSUPPRESSIVE AGENT; THALIDOMIDE;

ADULT; ARTICLE; CHI SQUARE DISTRIBUTION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; FOLLOW UP; HUMAN; LICHEN PLANUS; MALE; MIDDLE AGED; NONPARAMETRIC TEST; OINTMENT; PAIN ASSESSMENT; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SAFETY; TOPICAL DRUG ADMINISTRATION; TREATMENT OUTCOME;

ADMINISTRATION, TOPICAL; ADULT; ANTI-INFLAMMATORY AGENTS; CHI-SQUARE DISTRIBUTION; DEXAMETHASONE; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LICHEN PLANUS, ORAL; MALE; MIDDLE AGED; OINTMENTS; PAIN MEASUREMENT; PROSPECTIVE STUDIES; SAFETY; STATISTICS, NONPARAMETRIC; THALIDOMIDE; TREATMENT OUTCOME;

EID: 77955398984     PISSN: 10792104     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tripleo.2010.03.034     Document Type: Article

References (41)

1. J. Dusek, and W. Frick Lichen planus: oral manifestations and suggested treatments J Oral Maxillofac Surg 40 1982 240 244
2. C. Scully, and M. El-Kom Lichen planus: review and update on pathogenesis J Oral Pathol 14 1985 431 458
3. J.O. Andreasen Oral lichen planus. 1. A clinical evaluation of 115 cases Oral Surg Oral Med Oral Pathol Oral Radiol Endod 25 1968 31 42
4. N. Mollaoglu Oral lichen planus: a review Br J Oral Maxillofac Surg 38 2000 370 377
5. M.A. Gonzalez-Moles, C. Scully, and J.A. Gil-Montoya Oral lichen planus: controversies surrounding malignant transformation Oral Dis 14 2008 229 243
6. M.X. Fang, W.P. Zhang, Y. Chen, and Z.X. He Malignant transformation of oral lichen planus: a retrospective study of 23 cases Quintissence Int 40 2009 235 242
7. G. Lodi, C. Scully, M. Carrozzo, M. Griffiths, P.B. Sugerman, and K. Thongprasom Current controversies in oral lichen planus: report of an international consensus meeting. Part 2. Clinical management and malignant transformation Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100 2005 164 178 (Pubitemid 41020782)
8. S. Silverman, M. Gorsky, F. Lozada-Nur, and K. Giannotti A prospective study of findings and management in 214 patients with oral lichen planus Oral Surg Oral Med Oral Pathol Oral Radiol Endod 72 1991 665 670
9. N. Chainani-Wu, S. Silverman Jr, F. Lozada-Nur, P. Mayer, and J.J. Watson Oral lichen planus: patient profile, disease progression and treatment responses J Am Dent Assoc 132 2001 901 909
10. M.A. Ian, and J.B. Peter Molecular mechanisms of corticosteroid resistance Chest 134 2008 394 401
11. L. Manenschijn, E.L. Van den Akker, S.W. Lamberts, and E.F. Van Rossum Clinical features associated with glucocorticoid receptor polymorphisms Ann N Y Acad Sci 1179 2009 179 198
12. E. Charmandari, T. Kino, T. Ichijo, and G.P. Chrousos Generalized glucocorticoid resistance: clinical aspects, molecular mechanisms, and implications of a rare genetic disorder J Clin Endocrinol Metab 93 2008 1563 1572
13. Y. Niwa, T. Terashima, and H. Sumi Topical application of the immunosuppressant tacrolimus accelerates carcinogenesis in mouse skin Br J Dermatol 149 2003 960 967
14. T. Langeland, and V. Engh Topical use of tacrolimus and squamous cell carcinoma on the penis Br J Dermatol 152 2005 183 185
15. J.C. Becker, R. Houben, C.S. Vetter, and E. Brcker The carcinogenic potential of tacrolimus ointment beyond immune suppression: a hypothesis creating case report BMC Cancer 6 2006 7 13
16. Food and Drug Administration Postmarketing safety review: update on malignancy-related events in all age groups. ODS Postmarketing Safety Review Database on the Internet http://www.fda.gov/ohrms/dockets/ac/05/briefing/2005- 4089b2-01-06- Pimecrolimus%20Tacrolimus%20Malignancy%20Update%20Pitts%20PID%20040754%20040752. pdf 2004 Dec Accessed Dec 15, 2004
17. M.H. Thornhill Immune mechanisms in oral lichen planus Acta Odontol Scand 59 2001 174 177
18. G. Lodi, C. Scully, M. Carrozzo, M. Griffiths, P.B. Sugerman, and K. Thongprasom Current controversies in oral lichen planus: report of an international consensus meeting. Part 1. Viral infections and etiopathogenesis Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100 2005 40 51 (Pubitemid 40813390)
19. P.B. Sugerman, N.W. Savage, G.J. Seymour, and L.J. Walsh Is there a role for tumor necrosis factor alpha (TNF-α) in oral lichen planus? J Oral Pathol Med 25 1996 219 224
20. A. Sklavounou, E. Chrysomali, A. Scorilas, and A. Karameris TNF-α expression and apoptosis-regulation proteins in oral lichen planus: a comparative immunohistochemical evaluation J Oral Pathol Med 29 2000 370 375
21. C. Simark-Mattsson, G. Bergenholtz, M. Jontell, C. Eklund, G.J. Seymour, and P.B. Sugerman Distribution of interleukin-2, -4, -10, tumor necrosis factor-α and transforming growth factor-β mRNAs in oral lichen planus Arch Oral Biol 44 1999 499 507
22. N.L. Rhodus, B. Cheng, S. Myers, W. Bowles, V. Ho, and F. Ondrey A comparison of the pro-inflammatory, NF-κB-dependent cytokines: TNF-alpha, IL-1-alpha, IL-6, and IL-8 in different oral fluids from oral lichen planus patients Clin Immunol 114 2005 278 283
23. G. Zhou, M.W. Fan, and J.Y. Liu Regulation of BCG-polysaccharide nucleic acid on Thl/Th2 cytokines from peripheral blood mononuclear cells in oral lichen planus Chin J Dent Res 7 2004 5 10
24. S.J. Matthews, and C. McCoy Thalidomide: a review of approved and investigational uses Clin Ther 25 2003 342 395
25. E.F. Michael, R.M. Gordon, and D.F. William Thalidomide Lancet 363 2004 1802 1811
26. C. Camisa, and J.L. Popovsky Effective treatment of oral erosive lichen planus with thalidomide Arch Dermatol 136 2000 1442 1443
27. A. Macario-Barrel, X. Balguerie, and P. Joly Treatment of erosive oral lichen planus with thalidomide Ann Dermatol Venereol 130 2003 1109 1112
28. J.L. Tavares, A. Wangeo, P. Dilworth, B. Marshall, S. Kotecha, and R.J. Shaw Thalidomide reduces tumor necrosis factor-alpha production by human alveolar macrophages Respir Med 91 1997 31 39
29. S.M. McHugh, I.R. Rifkin, J. Deighton, A.B. Wilson, P.J. Lachmann, and C.M. Lockwood The immunosuppressive drug thalidomide induces T helper cell type 2 (Th2) and concomitantly inhibits Thl cytokine production in mitogen and antigen-stimulated human peripheral blood mononuclear cell cultures Clin Exp Immunol 99 1995 160 167
30. C.Z. Ni, H.Y. Song, and H.M. Zhou Topical thalidomide having good effect on refractory chronic discoid lupus erythematosus: a case report West China Journal of Stomatology 7 2007 306 307 Chinese
31. Clinical trial of topical thalidomide for aphthous stomatitis in patients with HIV/AIDS RFP: NIDCR-DR-04-15 http://www.docstoc.com 2008 Dec Accessed Apr 7, 2009. [Database on the Internet]
32. I. Al-Hashimi, M. Schifter, P.B. Lockhart, M. Brennan, A.J. Bruce, and J.B. Epstein Oral lichen planus and oral lichenoid lesions: diagnostic and therapeutic considerations Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103 2007 1 12
33. J.B. Zeldis, B.A. Williams, S.D. Thomas, and M.E. Elsayed S.T.E.P.S.: a comprehensive program for controlling and monitoring access to thalidomide Clin Ther 12 1999 319 330
34. G. Cavaletti, A. Beronio, L. Reni, E. Ghiglione, A. Schenone, and C. Briani Thalidomide sensory neurotoxicity: a clinical and neurophysiologic study Neurology 62 2004 2291 2293
35. C.C. Harland, G.B. Steventon, and J.R. Marsden Thalidomide-induced neuropathy and genetic differences in drug metabolism Eur J Clin Pharmacol 49 1995 1 6
36. S. Randell, and L. Cohen Erosive lichen planus Management of oral lesions with intralesional corticosteroid injections J Oral Med 29 1974 88 91
37. T. Ueno, K. Ishibashi, G. Kohama, and I. Furuta [A double-blind study on clinical effects of dexaltin ointment] Japanese Journal of Oral Surgery 26 1980 1399 1408 Japanese
38. N.L. Rhodus, B. Cheng, W. Bowles, S. Myers, L. Miller, and F. Ondrey Proinflammatory cytokine levels in saliva before and after treatment of (erosive) oral lichen planus with dexamethasone Oral Dis 12 2006 112 116
39. T.L. Rowland, S.M. McHugh, J. Deighton, R.J. Dearman, P.W. Ewan, and I. Kimber Differential regulation by thalidomide and dexamethasone of cytokine expression in human peripheral blood mononuclear cells Immunopharmacology 40 1998 11 20
40. G. Zhou, M.W. Fan, and J.Y. Liu Effects of glucocorticoids on T helper cell balance in oral lichen planus Chin J Stomatol 40 2005 98 101
41. S.J. George, and S. Hsu Lichen planopilaris treated with thalidomide J Am Acad Dermatol 45 2001 965 966