Left-shifted relation between calcium and parathyroid hormone in obesity

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 8, 2010, Pages 3973-3981

  Hultin, Hella ^a   Edfeldt, Katarina ^a   Sundbom, Magnus ^a   Hellman, Per ^a  

^a UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; ALBUMIN; CALCIUM; CITRATE CALCIUM; CREATININE; PARATHYROID HORMONE;

ADULT; ALBUMIN BLOOD LEVEL; ARTICLE; BODY MASS; BODY WEIGHT; CALCIUM BLOOD LEVEL; CALCIUM HOMEOSTASIS; COHORT ANALYSIS; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE DURATION; FEMALE; HUMAN; KIDNEY FAILURE; MAJOR CLINICAL STUDY; MALE; MORBID OBESITY; OBESITY; PARATHYROID FUNCTION; PARATHYROID HORMONE BLOOD LEVEL; PRIMARY HYPERPARATHYROIDISM; PRIORITY JOURNAL; SENSITIVITY ANALYSIS; VITAMIN BLOOD LEVEL;

EID: 77955388643     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-2822     Document Type: Article

References (45)

1. Bell NH, Epstein S, Greene A, Shary J, Oexmann MJ, Shaw S 1985 Evidence for alteration of the vitamin D-endocrine system in obese subjects. J Clin Invest 76:370-373 (Pubitemid 15243466)
2. Compston JE, Horton LW, Laker MF, Merrett AL, Woodhead JS, Gazet JC, Pilkington TR 1980 Treatment of bone disease after jejunoileal bypass for obesity with oral 1α-hydroxyvitamin D3. Gut 21:669-674 (Pubitemid 10020939)
3. Hamoui N, Anthone G, Crookes PF 2004 Calcium metabolism in the morbidly obese. Obes Surg 14:9-12
4. Buffington C, Walker B, Cowan Jr GS, Scruggs D 1993 Vitamin D Deficiency in the Morbidly Obese. Obes Surg 3:421-424
5. Hamoui N, Kim K, Anthone G, Crookes PF 2003 The significance of elevated levels of parathyroid hormone in patients with morbid obesity before and after bariatric surgery. Arch Surg 138:891-897 (Pubitemid 36960952)
6. Kamycheva E, Sundsfjord J, Jorde R 2004 Serum parathyroid hormone level is associated with body mass index. The 5th Tromso study. Eur J Endocrinol 151:167-172 (Pubitemid 39207010)
7. Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF 2000 Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 72:690-693
8. Ybarra J, Sanchez-Hernandez J, Perez A 2007 Hypovitaminosis D and morbid obesity. Nurs Clin North Am 42:19-27, v
9. Snow V, Barry P, Fitterman N, Qaseem A, Weiss K 2005 Pharmacologic and surgical management of obesity in primary care: a clinical practice guideline from the American College of Physicians. Ann Intern Med 142:525-531 (Pubitemid 40490918)
10. Shah M, Simha V, Garg A 2006 Long-term impact of bariatric surgery on body weight, comorbidities, and nutritional status. J Clin Endocrinol Metab 91:4223-4231
11. Goldner WS, Stoner JA, Thompson J, Taylor K, Larson L, Erickson J, McBride C 2008 Prevalence of vitamin D insufficiency and deficiency in morbidly obese patients: a comparison with non-obese controls. Obes Surg 18:145-150
12. Schwarz P, Sørensen HA, McNair P, Transbøl I 1993 Cica-clamp technique: a method for quantifying parathyroid hormone secretion: a sequential citrate and calcium clamp study. Eur J Clin Invest 23:546-553
13. Sørensen HA, Schwarz P, McNair P, Hyldstrup L, Transbøl I 1992 Calcium clamp technique: suppression of serum intact PTH by induced hypercalcaemia in normal man and primary hyperparathyroidism. Scand J Clin Lab Invest 52:457-465
14. Bas S, Aguilera-Tejero E, Bas A, Estepa JC, Lopez I, Madueño JA, Rodriguez M 2005 The influence of the progression of secondary hyperparathyroidism on the set point of the parathyroid hormonecalcium curve. J Endocrinol 184:241-247
15. Schwarz P, Madsen JC, Rasmussen AQ, Transbøl I, Brown EM 1998 Evidence for a role of intracellular stored parathyroid hormone in producing hysteresis of the PTH-calcium relationship in normal humans. Clin Endocrinol (Oxf) 48:725-732
16. Carlin AM, Rao DS, Meslemani AM, Genaw JA, Parikh NJ, Levy S, Bhan A, Talpos GB 2006 Prevalence of vitamin D depletion among morbidly obese patients seeking gastric bypass surgery. Surg Obes Relat Dis 2:98-103; discussion 104
17. Kull M, Kallikorm R, Lember M 2009 Body mass index determines sunbathing habits: implications on vitamin D levels. Intern Med J 39:256-258
18. Harris SS, Dawson-Hughes B 2007 Reduced sun exposure does not explain the inverse association of 25-hydroxyvitamin D with percent body fat in older adults. J Clin Endocrinol Metab 92:3155-3157
19. 3 in fat tissue. Endocrine 33:90-94
20. Bolland MJ, Grey AB, Gamble GD, Reid IR 2005 Association between primary hyperparathyroidism and increased body weight: a meta-analysis. J Clin Endocrinol Metab 90:1525-1530
21. Siilin H, Rastad J, Ljunggren O, Lundgren E 2008 Disturbances of calcium homeostasis consistent with mild primary hyperparathyroidism in premenopausal women and associated morbidity. J Clin Endocrinol Metab 93:47-53
22. Thomas MK, Lloyd-Jones DM, Thadhani RI, Shaw AC, Deraska DJ, Kitch BT, Vamvakas EC, Dick IM, Prince RL, Finkelstein JS 1998 Hypovitaminosis D in medical inpatients. N Engl J Med 338:777-783
23. Sahota O, Mundey MK, San P, Godber IM, Lawson N, Hosking DJ 2004 The relationship between vitamin D and parathyroid hormone: calcium homeostasis, bone turnover, and bone mineral density in postmenopausal women with established osteoporosis. Bone 35:312-319
24. Mayer GP, Hurst JG 1978 Sigmoidal relationship between parathyroid hormone secretion rate and plasma calcium concentration in calves. Endocrinology 102:1036-1042
25. Brown EM 1983 Four-parameter model of the sigmoidal relationship between parathyroid hormone release and extracellular calcium concentration in normal and abnormal parathyroid tissue. J Clin Endocrinol Metab 56:572-581
26. Nygren P, Larsson R, Lindh E, Ljunghall S, Rastad J, Akerström G, Gylfe E 1987 Bimodal regulation of secretion by cytoplasmic Ca2+ as demonstrated by the parathyroid. FEBS Lett 213:195-198
27. Brown EM 2002 The pathophysiology of primary hyperparathyroidism. J Bone Miner Res 17(Suppl 2):N24-N29
28. Habener JF, Rosenblatt M, Potts Jr JT 1984 Parathyroid hormone: biochemical aspects of biosynthesis, secretion, action and metabolism. Physiol Rev 64:985-1053
29. Estepa JC, Aguilera-Tejero E, Almaden Y, Rodriguez M, Felsenfeld AJ 1999 Effect of rate of calcium reduction and a hypocalcemic clamp on parathyroid hormone secretion: a study in dogs. Kidney Int 55:1724-1733
30. Grant FD, Conlin PR, Brown EM 1990 Rate and concentration dependence of parathyroid hormone dynamics during stepwise changes in serum ionized calcium in normal humans. J Clin Endocrinol Metab 71:370-378
31. Felsenfeld AJ, Rodríguez M, Aguilera-Tejero E 2007 Dynamics of parathyroid hormone secretion in health and secondary hyperparathyroidism. Clin J Am Soc Nephrol 2:1283-1305
32. Cloutier M, Brossard JH, Gascon-Barré M, D'Amour P 1994 Lack of involution of hyperplastic parathyroid glands in dogs: adaptation via a decrease in the calcium stimulation set point and a change in secretion profile. J Bone Miner Res 9:621-629
33. Mizunashi K, Furukawa Y, Goto MM, Abe K 1998 Sigmoidal curve shift in idiopathic hypoparathyroidism and pseudohypoparathyroidism. Calcif Tissue Int 62:290-294
34. Malberti F, Farina M, Imbasciati E 1999 The PTH-calcium curve and the set point of calcium in primary and secondary hyperparathyroidism. Nephrol Dial Transplant 14:2398-2406
35. Rodriguez M, Caravaca F, Fernandez E, Borrego MJ, Lorenzo V, Cubero J, Martin-Malo A, Betriu A, Rodriguez AP, Felsenfeld AJ 1997 Evidence for both abnormal set point of PTH stimulation by calcium and adaptation to serum calcium in hemodialysis patients with hyperparathyroidism. J Bone Miner Res 12:347-355
36. Pahl M, Jara A, Bover J, Rodriguez M, Felsenfeld AJ 1996 The set point of calcium and the reduction of parathyroid hormone in hemodialysis patients. Kidney Int 49:226-231 (Pubitemid 26022841)
37. Boucher A, D'Amour P, Hamel L, Fugère P, Gascon-Barré M, Lepage R, Ste-Marie LG 1989 Estrogen replacement decreases the set point of parathyroid hormone stimulation by calcium in normal postmenopausal women. J Clin Endocrinol Metab 68:831-836
38. Cosman F, Nieves J, Horton J, Shen V, Lindsay R 1994 Effects of estrogen on response to edetic acid infusion in postmenopausal osteoporotic women. J Clin Endocrinol Metab 78:939-943
39. Ridefelt P, Nygren P, Hellman P, Larsson R, Rastad J, Akerström G, Gylfe E 1992 Regulation of parathyroid hormone release in normal and pathological parathyroid cells exposed to modulators of protein kinase C. Acta Endocrinol 126:505-509
40. Ybarra J, Sánchez-Hernández J, Gich I, De Leiva A, Rius X, Rodríguez-Espinosa J, Pérez A 2005 Unchanged hypovitaminosis D and secondary hyperparathyroidism in morbid obesity after bariatric surgery. Obes Surg 15:330-335
41. Sánchez-Hernández J, Ybarra J, Gich I, De Leiva A, Rius X, Rodríguez-Espinosa J, Pérez A 2005 Effects of bariatric surgery on vitamin D status and secondary hyperparathyroidism: a prospective study. Obes Surg 15:1389-1395
42. Snijder MB, van Dam RM, Visser M, Deeg DJ, Dekker JM, Bouter LM, Seidell JC, Lips P 2005 Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women. J Clin Endocrinol Metab 90:4119-4123
43. Holick MF 2007 Vitamin D deficiency. N Engl J Med 357:266-281
44. Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R 2005 Estimates of optimal vitaminDstatus. Osteoporos Int 16:713-716
45. Malabanan A, Veronikis IE, Holick MF 1998 Redefining vitamin D insufficiency. Lancet 351:805-806