A scalable synthesis of a 1,7-naphthyridine derivative, a PDE-4 inhibitor

Organic Process Research and Development

Volumn 14, Issue 4, 2010, Pages 883-889

  Jiang, Xinglong ^a   Lee, George T ^a   Villhauer, Edwin B ^a   Prasad, Kapa ^a   Prashad, Mahavir ^a  

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

3-METHYLPYRIDINE; DICARBOXYLIC ACID; DIMETHYL ESTERS; NAPHTHYRIDINE; SCALABLE SYNTHESIS;

ESTERS; STEREOCHEMISTRY;

CYCLOHEXANE;

EID: 77955385340     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op100124x     Document Type: Article

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18. Details on these catalysts are as follows: POPd = dihydrogen dichlorobis(di- tert -butylphosphinito- κ P)palladate (2-), CAS # 391683-95-7 (supplier: Combiphos Catalysts Inc.); POPd1 = dihydrogen di-1-chlorotetrakis(di- tert -butylphosphinito- κ P)palladate (2-), CAS # 386706-31-6 (supplier: Combiphos Catalysts Inc.); POPd2 = dihydrogen di-1-dichlorodichlorobis(di- tert -butylphosphinito- κ P)palladate (2-), CAS # 386706-32-7 (supplier: Combiphos Catalysts Inc.); PS-Pd = Allyl-palladium dimer supported on poly(ethyleneglycol)polystyrene graft copolymer beads (supplier: Strem Chemicals, Inc.); FiberCat-1001 and Fibercat-1000-D7 are palladium catalysts anchored onto the polyethylene-based supported ligands (supplier: Johnson Matthey).