Effects of neutrophil elastase inhibitor on progression of acute lung injury after liver transplantation

Transplantation

Volumn 90, Issue 3, 2010, Pages 335-337

  Kaido, Toshimi ^a   Uemoto, Shinji ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

SIVELESTAT;

ACUTE LUNG INJURY; ARTERIAL OXYGEN TENSION; BLOOD VESSEL PERMEABILITY; CONTINUOUS INFUSION; CONTROLLED STUDY; DISEASE COURSE; HUMAN; HYPOXEMIA; LETTER; LIVER ISCHEMIA; LIVER TRANSPLANTATION; MAJOR CLINICAL STUDY; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; REPERFUSION INJURY; RESPIRATORY DISTRESS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ACUTE LUNG INJURY; GLYCINE; HUMANS; INFUSIONS, INTRAVENOUS; LEUKOCYTE ELASTASE; LIVER TRANSPLANTATION; PILOT PROJECTS; PROSPECTIVE STUDIES; PROTEASE INHIBITORS; SULFONAMIDES; TIME FACTORS; TREATMENT OUTCOME;

EID: 77955383047     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181e49bf2     Document Type: Letter

References (10)

1. Uchida Y, Freitas MC, Zhao D,etal. The protective function of neutrophil elastase inhibitor in liver ischemia/reperfusion injury. Transplantation 2010; 89: 1050.
2. Kaido T, Egawa H, Tsuji H, et al. In-hospital mortality in adult recipients of living donor liver transplantation: Experience of 576 consecutive cases at a single center. Liver Transpl 2009; 15: 1420.
3. Lee WL, Downey GP. Leukocyte elastase. Physiological functions and role in acute lung injury. Am J Respir Crit Care Med 2001; 164: 896.
4. Moreas TJ, Chow CW, Downey GP. Protease and lung injury. Crit Care Med 2003; 31: S189.
5. Kawabata K, Suzuki M, Sugitani K, et al. ONO-5046, a novel inhibitor of human neu-trophil elastase. Biochem Biophys Res Com-mun 1991; 177: 814.
6. Hagiwara S, Iwasaka H, Togo KA, et al. A neutrophil elastase inhibitor, sivelestat, reduces lung injury following endotoxin-induced shock in rats by inhibiting HMGB1. Inflammation 2008; 31: 227.
7. Yamaguchi Y, Matsumura F, Liang J, et al. Neutrophil elastase and oxygen radicals enhance monocyte chemoattractant protein-expression after ischemia/reperfusion in rat liver. Transplantation 1999; 68: 1459.
8. Muckart DJ, Bhagwanjee S. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference definitions of the systemic inflammatory response syndrome and allied disorders in relation to critically injured patients. Crit Care Med 1997; 25: 1789. 9.
9. Toyama S, Hatori F, Shimizu A, et al. A neu-trophil elastase inhibitor, sivelestat, improved respiratory and cardiac function in pediatric cardiovascular surgery with cardio-pulmonary bypass. J Anesth 2008; 22: 341. 10.
10. Matsuzaki K, Hiramatsu Y, Homma S, et al. Sivelestat reduces inflammatory mediators and preserves neutrophil deformability during simulated extracorporeal circulation. Ann Thorac Surg 2005; 80: 611.