Efficient synthesis of N4-methyl-and N4- hydroxycytidine phosphoramidites

Synthesis

Volumn , Issue 16, 2010, Pages 2708-2712

  Lu, Jun ^a   Li, Nan Sheng ^a   Koo, Selene C ^a   Piccirilli, Joseph A ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

N4 hydroxycytidine; N4 methylcytidine; nucleotides; oligonucleotides; phosphoramidites

Indexed keywords

BIOCHEMICAL TESTS; CYTIDINE; DEPROTECTION; EFFICIENT SYNTHESIS; N4-HYDROXYCYTIDINE; NUCLEOTIDE ANALOGUES; OLIGONUCLEOTIDE SYNTHESIS; PHOSPHORAMIDITES; PHYSICOCHEMICAL PROPERTY; RNA STRUCTURES; SOLID PHASE SYNTHESIS;

RNA;

OLIGONUCLEOTIDES;

2' O [(TERT BUTYL)DIMETHYLSILYL] 3',5' O (DI TERT BUTYLSILYLENE) N4 HYDROXYCYTIDINE; 2' O [(TERT BUTYL)DIMETHYLSILYL] 3',5' O (DI TERT BUTYLSILYLENE) N4 METHYLCYTIDINE; CYTIDINE DERIVATIVE; N4 ACETYL 2' O [(TERT BUTYL)DIMETHYLSILYL] 3',5' O (DI TERT BUTYLSILYLENE) N4 METHYLCYTIDINE; N4 ACETYL 2' O [(TERT BUTYL)DIMETHYLSILYL] 5' O (4,4' DIMETHOXYTRITYL) N4 METHYLCYTIDINE; N4 ACETYL 2' O [(TERT BUTYL)DIMETHYLSILYL] 5' O (4,4' DIMETHOXYTRITYL) N4 METHYLCYTIDINE 3' (2 CYANOETHYL) N,N DIISOPROPYLPHOSPHORAMIDITE; N4 ACETYL 2' O [(TERT BUTYL)DIMETHYLSILYL] N4 METHYLCYTIDINE; N4 BENZOYL 2' O [(TERT BUTYL)DIMETHYLSILYL] 3',5' O (DI TERT BUTYLSILYLENE) N4 HYDROXYCYTIDINE; N4 BENZOYL 2' O [(TERT BUTYL)DIMETHYLSILYL] 5' O (4,4' DIMETHOXYTRITYL) N4 HYDROXYCYTIDINE; N4 BENZOYL 2' O [(TERT BUTYL)DIMETHYLSILYL] 5' O (4,4' DIMETHOXYTRITYL) N4 HYDROXYCYTIDINE 3' (2 CYANOETHYL) N,N DIISOPROPYLPHOSPHORAMIDITE; N4 BENZOYL 2' O [(TERT BUTYL)DIMETHYLSILYL] N4 HYDROXYCYTIDINE; N4 HYDROXYCYTIDINE PHOSPHORAMIDOUS ACID; N4 METHYLCYTIDINE PHOSPHORAMIDOUS ACID; OLIGONUCLEOTIDE; PHOSPHORAMIDOUS ACID DERIVATIVE; RNA; UNCLASSIFIED DRUG; URIDINE;

ARTICLE; BIOCHEMISTRY; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PHYSICAL CHEMISTRY; PROTEIN FUNCTION; PROTON NUCLEAR MAGNETIC RESONANCE; RNA STRUCTURE; SOLID PHASE SYNTHESIS; SYNTHESIS;

EID: 77955377615     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0030-1258170     Document Type: Article

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