Molecular epidemiology of multidrug resistant extended-spectrum β-lactamase producing klebsiella pneumoniae outbreak in a neonatal intensive care unit

International Journal of Collaborative Research on Internal Medicine and Public Health

Volumn 2, Issue 7, 2010, Pages 226-237

  Mohamudha, Parveen R ^a   Srinivas, Acharya N ^a   Rahul, Dhodapkar ^a   Harish, B N ^a   Parija, S C ^a  

^a JAWAHARLAL INSTITUTE OF POSTGRADUATE MEDICAL EDUCATION AND RESEARCH   (India)

Author keywords

Extended spectrum lactamase; Klebsiella pneumoniae; Neonatal intensive care unit; Outbreak

Indexed keywords

AMIKACIN; AMPICILLIN; ANTIBIOTIC AGENT; CEFEPIME; CEFOTAXIME; CEFOXITIN; CEFTAZIDIME; CEFTRIAXONE; CEPHALOSPORIN; CHLORAMPHENICOL; CIPROFLOXACIN; CLAVULANIC ACID; COTRIMOXAZOLE; DNA; EXTENDED SPECTRUM BETA LACTAMASE; GENTAMICIN; IMIPENEM; MEROPENEM; PIPERACILLIN; PIPERACILLIN PLUS TAZOBACTAM; SULPERAZON;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIUM ISOLATION; BLOOD EXAMINATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISK DIFFUSION; EPIDEMIC; FEMALE; GENOTYPE; HUMAN; INDIA; KLEBSIELLA PNEUMONIAE; KLEBSIELLA PNEUMONIAE INFECTION; MALE; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR EPIDEMIOLOGY; MULTIDRUG RESISTANCE; NEWBORN; NEWBORN INTENSIVE CARE; NONHUMAN; PHENOTYPE; RANDOM AMPLIFIED POLYMORPHIC DNA; TERTIARY HEALTH CARE;

EID: 77955356887     PISSN: None     EISSN: 18404529     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Podschun R, Ullmann U. Klebsiella spp. as nosocomial pathogens:epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin Microbiol Rev, 1998; 11: 589-603.
2. Rice LB, Willey SH, Papanicolaou GA, et al. Outbreak of ceftazidime resistance caused by extended-spectrum β -lactamases at a Massachusetts chronic-care facility. Antimicrob Agents Chemother, 1990; 34:2193-99.
3. Bingen EH, Desjardins P, Arlet G, et al. Molecular epidemiology of plasmid spread among extended broad-spectrum β -lactamase-producing Klebsiella pneumoniae isolates in a pediatric hospital. J Clin Microbiol, 1993; 31:179-84.
4. Gniadkowski M. Evolution and epidemiology of extended-spectrum β - lactamases (ESBLs) and ESBL-producing microorganisms. Clin Microbiol Infect, 2001; 7: 597-608.
5. Olive DM, Bean I. Principles and applications of methods for DNA-based typing of microbial organisms. J Clin Microbiol, 1999; 37: 1661-69.
6. Belkum VA. DNA Fingerprinting of medically important microorganisms by use of PCR. Clin Microbiol Rev, 1994; 7: 174-84.
7. Collee JG, Miles RS, Watt B. Tests for the identification of bacteria. In Collee JG, Fraser AJ, Marmion BP, Simmons A, editors. Mackie & McCartney. Practical Medical Microbiology. London Churchill Livingstone., 1999: 131-49.
8. Clinical and Laboratory Standards Institute. Performance standards for antimicrobial disk susceptibility testing-11th ed. Approved Standard M100-S17. Clinical and Laboratory Standards Institute, 2007, Wayne, Pa., USA.
9. National committee for Clinical Laboratory Standards. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically-6th ed. Approved standard M7-A6. National committee for Clinical Laboratory Standards, 2003, Wayne, Pa., USA.
10. Arpin C, Dubois V, Coulange L, et al. Extended spectrum β -lactamase producing Enterobacteriaceae in community and private health care centers. Antimicrob Agents Chemother, 2003; 4: 3506-14.
11. Gheldre DY, Avesani V, Berhin C, et al. Evaluation of Oxoid combination discs for detection of extended spectrum β -lactamases. J Antimicrob Chemother, 2003; 52: 591-7.
12. Pitout JD, Hamilton N, Church DL, et al. Development and clinical validation of a molecular diagnostic assay to detect CTX-M-type β-lactamases in Enterobacteriaceae. Clin Microbiol Infect, 2007; 13: 291-7.
13. Tribuddharat C, Srifuengfung S, Chiangjong W. Preliminary Study of Randomly-Amplified Polymorphic DNA Analysis for Typing Extended- Spectrum Beta-Lactamase (ESBL)-Producing Klebsiella pneumoniae. J Med Assoc Thai, 2008; 91: 527-32.
14. Hamouda TB, Foulon T, Masmoudi A, et al. Molecular epidemiology of an outbreak of multiresistant Klebsiella pneumoniae in a Tunisian neonatal ward. J Med Microbiol, 2003; 52: 427-33.
15. Branger C, Lesimple AL, Bruneau B, et al. Long-term investigation of the clonal dissemination of Klebsiella pneumoniae isolates producing extended-spectrum β- lactamases in a university hospital. J Med Microbiol, 1998; 47; 201-9.
16. Silva CL, Moreira BM, Almeida VC, et al. Extended-spectrum-β -lactamaseproducing Klebsiella pneumoniae in a neonatal intensive care unit: risk factors for infection and colonization. J Hosp Infection, 1999; 53: 198-206.
17. Stoll BJ. Infections of the neonatal infants. In: Behrman RE, Klegman RM, Jenson HB, editors. Nelson text book of pediatrics. Philadelphia: Saunders, 2004: 623-38.
18. Zhanel GG, Wiebe R, Dilay L, et al. Comparative review of the carbapenems. Drug, 2007; 67:1027-52.
19. Toltzis P, Yamashita T, Vilt L, et al. Colonization with antibiotic-resistant gramnegative organisms in a pediatric intensive care unit. Crit Care Med, 1997; 25: 538-44.
20. Lopesa ACS, Rodriguesb JF, Juniorb MAM. Molecular typing of Klebsiella pneumoniae isolates from public hospitals in Recife. Brazil Microbiol Research, 2005; 160:37-46.