Removal of electrophilic potential genotoxic impurities using nucleophilic reactive resins

Organic Process Research and Development

Volumn 14, Issue 4, 2010, Pages 1021-1026

  Lee, Claire ^a   Helmy, Roy ^a   Strulson, Christopher ^a   Plewa, Jolanta ^a   Kolodziej, Elizabeth ^a   Antonucci, Vincent ^a   Mao, Bing ^a   Welch, Christopher J ^a   Ge, Zhihong ^a   Al Sayah, Mohammad A ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE PHARMACEUTICAL INGREDIENTS; BENZENESULFONIC ACID; DOWNSTREAM-PROCESSING; GENOTOXIC IMPURITIES; HIGH YIELD; IDEAL SOLUTIONS; MATRIX EFFECTS; METHANE SULFONIC ACID; NUCLEOPHILIC RESINS; PREPARATIVE CHROMATOGRAPHY; PROCESS DEVELOPMENT; REACTIVE RESIN; RECRYSTALLIZATIONS; RESIN LOADING; SOLVENT CONSUMPTION; SOLVENT EFFECTS; TOXIC IMPURITIES;

CHEMICAL COMPOUNDS; CHROMATOGRAPHY; ESTERIFICATION; ESTERS; LEAD COMPOUNDS; RESINS;

REMOVAL;

EID: 77955355500     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op1000397     Document Type: Article

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