Assessing the accuracy of adherence and sexual behaviour data in the MDP301 Vaginal microbicides trial using a mixed methods and triangulation model

PLoS ONE

Volumn 5, Issue 7, 2010, Pages

  Pool, Robert ^a,i   Montgomery, Catherine M ^a   Morar, Neetha S ^b   Mweemba, Oliver ^c   Ssali, Agnes ^d   Gafos, Mitzy ^e   Lees, Shelley ^f   Stadler, Jonathan ^g   Nunn, Andrew ^h   Crook, Angela ^h   Hayes, Richard ^f   McCormack, Sheena ^h  

^a CENTRE FOR RESEARCH IN ENVIRONMENTAL EPIDEMIOLOGY CREAL   (Spain)

^b SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

^c UNIVERSITY OF ZAMBIA   (Zambia)

^d UGANDA VIRUS RESEARCH INSTITUTE   (Uganda)

^e UNIVERSITY OF KWAZULU NATAL   (South Africa)

^f LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^g UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^h MEDICAL RESEARCH COUNCIL   (United Kingdom)

ⁱ UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

MICROBICIDE; ANTIINFECTIVE AGENT;

ANALYTIC METHOD; ARTICLE; CLINICAL TRIAL; COITUS; CONDOM; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; GEL; HEALTH PROGRAM; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MEDICAL RECORD; MIXED METHODS; PATIENT ATTITUDE; RANDOMIZED CONTROLLED TRIAL; SEXUAL BEHAVIOR; STATISTICAL MODEL; STRUCTURED INTERVIEW; SYSTEMATIC ERROR; TRIANGULATION METHOD; INTERVIEW; INTRAVAGINAL DRUG ADMINISTRATION;

ADMINISTRATION, INTRAVAGINAL; ANTI-INFECTIVE AGENTS; CONDOMS; FEMALE; HUMANS; INTERVIEWS AS TOPIC; SEXUAL BEHAVIOR;

EID: 77955350750     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0011632     Document Type: Article

References (7)

1. Pool R, Montgomery C, Morar N, Mweemba O, Ssali A, et al. (2010) A mixed methods and triangulation model for increasing the accuracy of adherence and sexual behaviour data: the Microbicides Development Programme. PLoS One.
2. Lagakos S, Gable A, eds (2008) Methodological Challenges in Biomedical HIV Prevention Trials. Washington DC: National Academies Press.
3. Tolley EE, Harrison PF, Goetghebeur E, Morrow K, Pool R, et al. (2009) Adherence and Its Measurement in Phase 2/3 Microbicide Trials. AIDS and Behaviour DOI 10.1007/s10461-009-9635-x.
4. Nunn A, McCormack S, Crook AM, Pool R, Rutterford C, et al. (2009) Microbicides Development Programme: Design of a phase III trial to measure the efficacy of the vaginal microbicide PRO 2000/5 for HIV prevention. Trials 10.
5. Population Council (2008) Informed Consent in HIV Prevention Trials. Highlights from an International Workshop. New York: The Population Council.
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