-
1
-
-
0033817023
-
A single amino acid substitution in region 1.2 of the principal σ factor of Streptomyces coelicolor A3(2) results in pleiotropic loss of antibiotic production
-
Aigle, B., Wietzorrek, A., Takano, E. & Bibb, M. J. (2000). A single amino acid substitution in region 1.2 of the principal σ factor of Streptomyces coelicolor A3(2) results in pleiotropic loss of antibiotic production. Mol Microbiol 37, 995-1004.
-
(2000)
Mol Microbiol
, vol.37
, pp. 995-1004
-
-
Aigle, B.1
Wietzorrek, A.2
Takano, E.3
Bibb, M.J.4
-
2
-
-
2042475439
-
Structural basis for transcription regulation by alarmone ppGpp
-
Artsimovitch, I., Patlan, V., Sekine, S., Vassylyeva, M. N., Hosaka, T., Ochi, K., Yokoyama, S. & Vassylyev, D. G. (2004). Structural basis for transcription regulation by alarmone ppGpp. Cell 117, 299-310.
-
(2004)
Cell
, vol.117
, pp. 299-310
-
-
Artsimovitch, I.1
Patlan, V.2
Sekine, S.3
Vassylyeva, M.N.4
Hosaka, T.5
Ochi, K.6
Yokoyama, S.7
Vassylyev, D.G.8
-
3
-
-
0037046560
-
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)
-
Bentley, S. D., Chater, K. F., Cerdeno-Tarraga, A. M., Challis, G. L., Thomson, N. R., James, K. D., Harris, D. E., Quail, M. A., Kieser, H. & other authors (2002). Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature 417, 141-147.
-
(2002)
Nature
, vol.417
, pp. 141-147
-
-
Bentley, S.D.1
Chater, K.F.2
Cerdeno-Tarraga, A.M.3
Challis, G.L.4
Thomson, N.R.5
James, K.D.6
Harris, D.E.7
Quail, M.A.8
Kieser, H.9
-
4
-
-
15744383448
-
Regulation of secondary metabolism in streptomycetes
-
Bibb, M. J. (2005). Regulation of secondary metabolism in streptomycetes. Curr Opin Microbiol 8, 208-215.
-
(2005)
Curr Opin Microbiol
, vol.8
, pp. 208-215
-
-
Bibb, M.J.1
-
5
-
-
30344476728
-
New horizons for (p)ppGpp in bacterial and plant physiology
-
Braeken, K., Moris, M., Daniels, R., Vanderleyden, J. & Michiels, J. (2006). New horizons for (p)ppGpp in bacterial and plant physiology. Trends Microbiol 14, 45-54.
-
(2006)
Trends Microbiol
, vol.14
, pp. 45-54
-
-
Braeken, K.1
Moris, M.2
Daniels, R.3
Vanderleyden, J.4
Michiels, J.5
-
6
-
-
0026602372
-
Isolation and characterization of the major vegetative RNA polymerase of Streptomyces coelicolor A3(2); renaturation of a sigma subunit using GroEL
-
Brown, K. L., Wood, S. & Buttner, M. J. (1992). Isolation and characterization of the major vegetative RNA polymerase of Streptomyces coelicolor A3(2); renaturation of a sigma subunit using GroEL. Mol Microbiol 6, 1133-1139.
-
(1992)
Mol Microbiol
, vol.6
, pp. 1133-1139
-
-
Brown, K.L.1
Wood, S.2
Buttner, M.J.3
-
7
-
-
0026634129
-
Construction and characterization of Streptomyces coelicolor A3(2) mutants that are multiply deficient in the non-essential hrd-encoded RNA polymerase sigma factors
-
Buttner, M. J. & Lewis, C. G. (1992). Construction and characterization of Streptomyces coelicolor A3(2) mutants that are multiply deficient in the non-essential hrd-encoded RNA polymerase sigma factors. J Bacteriol 174, 5165-5167.
-
(1992)
J Bacteriol
, vol.174
, pp. 5165-5167
-
-
Buttner, M.J.1
Lewis, C.G.2
-
8
-
-
0025301553
-
Cloning, disruption, and transcriptional analysis of three RNA polymerase sigma factor genes of Streptomyces coelicolor A3(2)
-
Buttner, M. J., Chater, K. F. & Bibb, M. J. (1990). Cloning, disruption, and transcriptional analysis of three RNA polymerase sigma factor genes of Streptomyces coelicolor A3(2). J Bacteriol 172, 3367-3378.
-
(1990)
J Bacteriol
, vol.172
, pp. 3367-3378
-
-
Buttner, M.J.1
Chater, K.F.2
Bibb, M.J.3
-
9
-
-
0003174053
-
The stringent response
-
2nd edn, Edited by F. C. Neidhardt and others. Washington, DC: American Society for Microbiology
-
Cashel, M., Gentry, D. R., Hernandez, V. J. & Vinella, D. (1996). The stringent response, In Escherichia coli and Salmonella: Cellular and Molecular Biology, 2nd edn, pp. 1458-1496. Edited by F. C. Neidhardt and others. Washington, DC: American Society for Microbiology.
-
(1996)
Escherichia Coli and Salmonella: Cellular and Molecular Biology
, pp. 1458-1496
-
-
Cashel, M.1
Gentry, D.R.2
Hernandez, V.J.3
Vinella, D.4
-
10
-
-
0030922782
-
The ppGpp synthetase gene (relA) of Streptomyces coelicolor A3(2) plays a conditional role in antibiotic production and morphological differentiation
-
Chakraburtty, R. & Bibb, M. (1997). The ppGpp synthetase gene (relA) of Streptomyces coelicolor A3(2) plays a conditional role in antibiotic production and morphological differentiation. J Bacteriol 179, 5854-5861.
-
(1997)
J Bacteriol
, vol.179
, pp. 5854-5861
-
-
Chakraburtty, R.1
Bibb, M.2
-
11
-
-
0031949801
-
The mediator for stringent control, ppGpp, binds to the β-subunit of Escherichia coli RNA polymerase
-
Chatterji, D., Fujita, N. & Ishihama, A. (1998). The mediator for stringent control, ppGpp, binds to the β-subunit of Escherichia coli RNA polymerase. Genes Cells 3, 279-287.
-
(1998)
Genes Cells
, vol.3
, pp. 279-287
-
-
Chatterji, D.1
Fujita, N.2
Ishihama, A.3
-
12
-
-
0030012602
-
redD and actII-ORF4, pathway-specific regulatory genes for antibiotic production in Streptomyces coelicolor A3(2), are transcribed in vitro by an RNA polymerase holoenzyme containing shrdD
-
Fujii, T., Gramajo, H. C., Takano, E. & Bibb, M. J. (1996). redD and actII-ORF4, pathway-specific regulatory genes for antibiotic production in Streptomyces coelicolor A3(2), are transcribed in vitro by an RNA polymerase holoenzyme containing shrdD. J Bacteriol 178, 3402-3405.
-
(1996)
J Bacteriol
, vol.178
, pp. 3402-3405
-
-
Fujii, T.1
Gramajo, H.C.2
Takano, E.3
Bibb, M.J.4
-
13
-
-
0027483415
-
Stationary-phase production of the antibiotic actinorhodin in Streptomyces coelicolor A3(2) is transcriptionally regulated
-
Gramajo, H. C., Takano, E. & Bibb, M. J. (1993). Stationary-phase production of the antibiotic actinorhodin in Streptomyces coelicolor A3(2) is transcriptionally regulated. Mol Microbiol 7, 837-845.
-
(1993)
Mol Microbiol
, vol.7
, pp. 837-845
-
-
Gramajo, H.C.1
Takano, E.2
Bibb, M.J.3
-
14
-
-
0020546194
-
Genetic analysis of A-factor synthesis in Streptomyces coelicolor A3(2) and Streptomyces griseus
-
Hara, O., Horinouchi, S., Uozumi, T. & Beppu, T. (1983). Genetic analysis of A-factor synthesis in Streptomyces coelicolor A3(2) and Streptomyces griseus. J Gen Microbiol 129, 2939-2944.
-
(1983)
J Gen Microbiol
, vol.129
, pp. 2939-2944
-
-
Hara, O.1
Horinouchi, S.2
Uozumi, T.3
Beppu, T.4
-
15
-
-
0035181472
-
Induction of ppGpp synthesis in Streptomyces coelicolor A3(2) grown under conditions of nutritional sufficiency elicits actII-ORF4 transcription and actinorhodin biosynthesis
-
Hesketh, A., Sun, J. & Bibb, M. (2001). Induction of ppGpp synthesis in Streptomyces coelicolor A3(2) grown under conditions of nutritional sufficiency elicits actII-ORF4 transcription and actinorhodin biosynthesis. Mol Microbiol 39, 136-144.
-
(2001)
Mol Microbiol
, vol.39
, pp. 136-144
-
-
Hesketh, A.1
Sun, J.2
Bibb, M.3
-
16
-
-
38349086492
-
The global role of ppGpp synthesis in morphological differentiation and antibiotic production in Streptomyces coelicolor A3(2)
-
Hesketh, A., Chen, W. J., Ryding, J., Chang, S. & Bibb, M. J. (2007). The global role of ppGpp synthesis in morphological differentiation and antibiotic production in Streptomyces coelicolor A3(2). Genome Biol 8, R161.
-
(2007)
Genome Biol
, vol.8
-
-
Hesketh, A.1
Chen, W.J.2
Ryding, J.3
Chang, S.4
Bibb, M.J.5
-
17
-
-
66149185679
-
Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12
-
Hosaka, T., Ohnishi-Kameyama, M., Muramatsu, H., Murakami, K., Tsurumi, Y., Kodani, S., Yoshida, M., Fujie, A. & Ochi, K. (2009). Antibacterial discovery in actinomycetes strains with mutations in RNA polymerase or ribosomal protein S12. Nat Biotechnol 27, 462-464.
-
(2009)
Nat Biotechnol
, vol.27
, pp. 462-464
-
-
Hosaka, T.1
Ohnishi-Kameyama, M.2
Muramatsu, H.3
Murakami, K.4
Tsurumi, Y.5
Kodani, S.6
Yoshida, M.7
Fujie, A.8
Ochi, K.9
-
18
-
-
0036299643
-
Activation of antibiotic biosynthesis by specific mutations in the rpoB gene (encoding the RNA polymerase β subunit) of Streptomyces lividans
-
Hu, H., Zhang, Q. & Ochi, K. (2002). Activation of antibiotic biosynthesis by specific mutations in the rpoB gene (encoding the RNA polymerase β subunit) of Streptomyces lividans. J Bacteriol 184, 3984-3991.
-
(2002)
J Bacteriol
, vol.184
, pp. 3984-3991
-
-
Hu, H.1
Zhang, Q.2
Ochi, K.3
-
19
-
-
0035576880
-
Global analysis of growth phase responsive gene expression and regulation of antibiotic biosynthetic pathways in Streptomyces coelicolor using DNA microarrays
-
Huang, J., Lih, C. J., Pan, K. H. & Cohen, S. N. (2001). Global analysis of growth phase responsive gene expression and regulation of antibiotic biosynthetic pathways in Streptomyces coelicolor using DNA microarrays. Genes Dev 15, 3183-3192.
-
(2001)
Genes Dev
, vol.15
, pp. 3183-3192
-
-
Huang, J.1
Lih, C.J.2
Pan, K.H.3
Cohen, S.N.4
-
20
-
-
33749646813
-
Physiological analysis of the stringent response elicited in an extreme thermophilic bacterium, Thermus thermophilus
-
Kasai, K., Nishizawa, T., Takahashi, K., Hosaka, T., Aoki, H. & Ochi, K. (2006). Physiological analysis of the stringent response elicited in an extreme thermophilic bacterium, Thermus thermophilus. J Bacteriol 188, 7111-7122.
-
(2006)
J Bacteriol
, vol.188
, pp. 7111-7122
-
-
Kasai, K.1
Nishizawa, T.2
Takahashi, K.3
Hosaka, T.4
Aoki, H.5
Ochi, K.6
-
21
-
-
0003869903
-
-
Norwich, UK: John Innes Foundation
-
Kieser, T., Bibb, M. J., Buttner, M. J., Chater, K. F. & Hopwood, D. A. (2000). Practical Streptomyces Genetics. Norwich, UK: John Innes Foundation.
-
(2000)
Practical Streptomyces Genetics
-
-
Kieser, T.1
Bibb, M.J.2
Buttner, M.J.3
Chater, K.F.4
Hopwood, D.A.5
-
22
-
-
0036856382
-
Genetic and physiological characterization of rpoB mutations that activate antibiotic production in Streptomyces lividans
-
Lai, C., Xu, J., Tozawa, Y., Okamoto-Hosoya, Y., Yao, X. & Ochi, K. (2002). Genetic and physiological characterization of rpoB mutations that activate antibiotic production in Streptomyces lividans. Microbiology 148, 3365-3378.
-
(2002)
Microbiology
, vol.148
, pp. 3365-3378
-
-
Lai, C.1
Xu, J.2
Tozawa, Y.3
Okamoto-Hosoya, Y.4
Yao, X.5
Ochi, K.6
-
23
-
-
34248349446
-
Mutations in rsmG, encoding a 16S rRNA methyltransferase, result in low-level streptomycin resistance and antibiotic overproduction in Streptomyces coelicolor A3(2)
-
Nishimura, K., Hosaka, T., Tokuyama, S., Okamoto, S. & Ochi, K. (2007). Mutations in rsmG, encoding a 16S rRNA methyltransferase, result in low-level streptomycin resistance and antibiotic overproduction in Streptomyces coelicolor A3(2). J Bacteriol 189, 3876-3883.
-
(2007)
J Bacteriol
, vol.189
, pp. 3876-3883
-
-
Nishimura, K.1
Hosaka, T.2
Tokuyama, S.3
Okamoto, S.4
Ochi, K.5
-
24
-
-
0023626550
-
Metabolic initiation of differentiation and secondary metabolism by Streptomyces griseus: Significance of the stringent response (ppGpp) and GTP content in relation to A-factor
-
Ochi, K. (1987). Metabolic initiation of differentiation and secondary metabolism by Streptomyces griseus: significance of the stringent response (ppGpp) and GTP content in relation to A-factor. J Bacteriol 169, 3608-3616.
-
(1987)
J Bacteriol
, vol.169
, pp. 3608-3616
-
-
Ochi, K.1
-
25
-
-
0025299089
-
Streptomyces relC mutants with an altered ribosomal protein ST-L11 and genetic analysis of a Streptomyces griseus relC mutant
-
Ochi, K. (1990a). Streptomyces relC mutants with an altered ribosomal protein ST-L11 and genetic analysis of a Streptomyces griseus relC mutant. J Bacteriol 172, 4008-4016.
-
(1990)
J Bacteriol
, vol.172
, pp. 4008-4016
-
-
Ochi, K.1
-
26
-
-
0025685440
-
A relaxed (rel) mutant of Streptomyces coelicolor A3(2) with a missing ribosomal protein lacks the ability to accumulate ppGpp, a-factor and prodigiosin
-
Ochi, K. (1990b). A relaxed (rel) mutant of Streptomyces coelicolor A3(2) with a missing ribosomal protein lacks the ability to accumulate ppGpp, A-factor and prodigiosin. J Gen Microbiol 136, 2405-2412.
-
(1990)
J Gen Microbiol
, vol.136
, pp. 2405-2412
-
-
Ochi, K.1
-
27
-
-
34347344063
-
From microbial differentiation to ribosome engineering
-
Ochi, K. (2007). From microbial differentiation to ribosome engineering. Biosci Biotechnol Biochem 71, 1373-1386.
-
(2007)
Biosci Biotechnol Biochem
, vol.71
, pp. 1373-1386
-
-
Ochi, K.1
-
28
-
-
0030784850
-
Molecular and functional analysis of the ribosomal L11 and S12 protein genes (rplK and rpsL) of Streptomyces coelicolor A3(2)
-
Ochi, K., Zhang, D., Kawamoto, S. & Hesketh, A. (1997). Molecular and functional analysis of the ribosomal L11 and S12 protein genes (rplK and rpsL) of Streptomyces coelicolor A3(2). Mol Gen Genet 256, 488-498.
-
(1997)
Mol Gen Genet
, vol.256
, pp. 488-498
-
-
Ochi, K.1
Zhang, D.2
Kawamoto, S.3
Hesketh, A.4
-
29
-
-
0344012013
-
An aberrant protein synthesis activity is linked with antibiotic overproduction in rpsL mutants of Streptomyces coelicolor A3(2)
-
Okamoto-Hosoya, Y., Hosaka, T. & Ochi, K. (2003). An aberrant protein synthesis activity is linked with antibiotic overproduction in rpsL mutants of Streptomyces coelicolor A3(2). Microbiology 149, 3299-3309.
-
(2003)
Microbiology
, vol.149
, pp. 3299-3309
-
-
Okamoto-Hosoya, Y.1
Hosaka, T.2
Ochi, K.3
-
30
-
-
33745444059
-
EshA accentuates ppGpp accumulation and is conditionally required for antibiotic production in Streptomyces coelicolor A3(2)
-
Saito, N., Xu, J., Hosaka, T., Okamoto, S., Aoki, H., Bibb, M. J. & Ochi, K. (2006). EshA accentuates ppGpp accumulation and is conditionally required for antibiotic production in Streptomyces coelicolor A3(2). J Bacteriol 188, 4952-4961.
-
(2006)
J Bacteriol
, vol.188
, pp. 4952-4961
-
-
Saito, N.1
Xu, J.2
Hosaka, T.3
Okamoto, S.4
Aoki, H.5
Bibb, M.J.6
Ochi, K.7
-
31
-
-
0030448016
-
Induction of actinorhodin production by rpsL (encoding ribosomal protein S12) mutations that confer streptomycin resistance in Streptomyces lividans and Streptomyces coelicolor A3(2)
-
Shima, J., Hesketh, A., Okamoto, S., Kawamoto, S. & Ochi, K. (1996). Induction of actinorhodin production by rpsL (encoding ribosomal protein S12) mutations that confer streptomycin resistance in Streptomyces lividans and Streptomyces coelicolor A3(2). J Bacteriol 178, 7276-7284.
-
(1996)
J Bacteriol
, vol.178
, pp. 7276-7284
-
-
Shima, J.1
Hesketh, A.2
Okamoto, S.3
Kawamoto, S.4
Ochi, K.5
-
32
-
-
0035036356
-
Functional analysis of relA and rshA, two relA/spoT homologues of Streptomyces coelicolor A3(2)
-
Sun, J., Hesketh, A. & Bibb, M. (2001). Functional analysis of relA and rshA, two relA/spoT homologues of Streptomyces coelicolor A3(2). J Bacteriol 183, 3488-3498.
-
(2001)
J Bacteriol
, vol.183
, pp. 3488-3498
-
-
Sun, J.1
Hesketh, A.2
Bibb, M.3
-
33
-
-
0026784840
-
Transcriptional regulation of the redD transcriptional activator gene accounts for growth-phase-dependent production of the antibiotic undecylprodigiosin in Streptomyces coelicolor A3(2)
-
Takano, E., Gramajo, H. C., Strauch, E., Andres, N., White, J. & Bibb, M. J. (1992). Transcriptional regulation of the redD transcriptional activator gene accounts for growth-phase-dependent production of the antibiotic undecylprodigiosin in Streptomyces coelicolor A3(2). Mol Microbiol 6, 2797-2804.
-
(1992)
Mol Microbiol
, vol.6
, pp. 2797-2804
-
-
Takano, E.1
Gramajo, H.C.2
Strauch, E.3
Andres, N.4
White, J.5
Bibb, M.J.6
-
34
-
-
63449126395
-
Activation of dormant bacterial genes by Nonomuraea sp. strain ATCC 39727 mutant-type RNA polymerase
-
Tala, A., Wang, G., Zemanova, M., Okamoto, S., Ochi, K. & Alifano, P. (2009). Activation of dormant bacterial genes by Nonomuraea sp. strain ATCC 39727 mutant-type RNA polymerase. J Bacteriol 191, 805-814.
-
(2009)
J Bacteriol
, vol.191
, pp. 805-814
-
-
Tala, A.1
Wang, G.2
Zemanova, M.3
Okamoto, S.4
Ochi, K.5
Alifano, P.6
-
35
-
-
43049129603
-
Dramatic activation of antibiotic production in Streptomyces coelicolor by cumulative drug resistance mutations
-
Wang, G., Hosaka, T. & Ochi, K. (2008). Dramatic activation of antibiotic production in Streptomyces coelicolor by cumulative drug resistance mutations. Appl Environ Microbiol 74, 2834-2840.
-
(2008)
Appl Environ Microbiol
, vol.74
, pp. 2834-2840
-
-
Wang, G.1
Hosaka, T.2
Ochi, K.3
-
36
-
-
0036809217
-
Dissection of the mechanism for the stringent factor RelA
-
Wendrich, T. M., Blaha, G., Wilson, D. N., Marahiel, M. A. & Nierhaus, K. H. (2002). Dissection of the mechanism for the stringent factor RelA. Mol Cell 10, 779-788.
-
(2002)
Mol Cell
, vol.10
, pp. 779-788
-
-
Wendrich, T.M.1
Blaha, G.2
Wilson, D.N.3
Marahiel, M.A.4
Nierhaus, K.H.5
-
37
-
-
0036460093
-
A rifampicin resistance mutation in the rpoB gene confers ppGpp-independent antibiotic production in Streptomyces coelicolor A3(2)
-
Xu, J., Tozawa, Y., Lai, C., Hayashi, H. & Ochi, K. (2002). A rifampicin resistance mutation in the rpoB gene confers ppGpp-independent antibiotic production in Streptomyces coelicolor A3(2). Mol Genet Genomics 268, 179-189.
-
(2002)
Mol Genet Genomics
, vol.268
, pp. 179-189
-
-
Xu, J.1
Tozawa, Y.2
Lai, C.3
Hayashi, H.4
Ochi, K.5
|