ANCA-positive vasculitis associated with simvastatin/ezetimibe: Expanding the spectrum of statin-induced autoimmunity?

International Journal of Rheumatic Diseases

Volumn 13, Issue 3, 2010, Pages

  Sen, Deepali ^a   Rosenstein, Elliot D ^a,b   Kramer, Neil ^a,b  

^a SAINT BARNABAS MEDICAL CENTER   (United States)

^b Center for Rheumatic and Autoimmune Diseases   (United States)

Author keywords

ANCA; Autoimmune diseases; Statins; Vasculitis

Indexed keywords

ALLOPURINOL; ANTINUCLEAR ANTIBODY; AZITHROMYCIN; C REACTIVE PROTEIN; CEFADROXIL; CELL NUCLEUS ANTIGEN; COLCHICINE; CREATININE; DOUBLE STRANDED DNA; EZETIMIBE PLUS SIMVASTATIN; HEMOGLOBIN; IMMUNOGLOBULIN A; MYELOPEROXIDASE; PREDNISONE; UREA;

ADULT; ALLERGIC VASCULITIS; ANCA ASSOCIATED VASCULITIS; ANKLE EDEMA; ANKLE INJURY; ARTICLE; ASTHMA; AUTOIMMUNITY; BLOOD PRESSURE; BODY TEMPERATURE; BRONCHITIS; CASE REPORT; CAUCASIAN; CELLULITIS; CHILL; CLINICAL FEATURE; CREATININE BLOOD LEVEL; DERMATOLOGY; DRUG WITHDRAWAL; ERYTHROCYTE COUNT; ERYTHROCYTE SEDIMENTATION RATE; FEVER; GOUT; HEMATURIA; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPERCHOLESTEROLEMIA; IMMUNOELECTROPHORESIS; IMMUNOSUPPRESSIVE TREATMENT; JOINT SWELLING; LEUKOCYTE COUNT; LEUKOCYTOCLASTIC VASCULITIS; MALE; MUCOSA; NEUROLOGIC EXAMINATION; PATIENT REFERRAL; PERIARTHRITIS; PHYSICAL EXAMINATION; PRIORITY JOURNAL; PROTEIN URINE LEVEL; PURPURA; PURPURIC RASH; RHEUMATOLOGY; SEROLOGY; SKIN ULCER; SYNOVITIS; UREA NITROGEN BLOOD LEVEL; URINALYSIS;

ANTI-NEUTROPHIL CYTOPLASMIC ANTIBODY-ASSOCIATED VASCULITIS; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; ANTICHOLESTEREMIC AGENTS; AUTOIMMUNITY; AZETIDINES; BIOLOGICAL MARKERS; DRUG COMBINATIONS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MALE; MIDDLE AGED; PEROXIDASE; RIBONUCLEOPROTEINS; SIMVASTATIN;

EID: 77955342931     PISSN: 17561841     EISSN: 1756185X     Source Type: Journal    
DOI: 10.1111/j.1756-185X.2010.01481.x     Document Type: Article

References (9)

1. Noel B. Lupus erythematosus and other autoimmune diseases related to statin therapy: a systematic review. J Eur Acad Dermatol Venereol 2007, 21:17-24.
2. Merkel PA. Drugs associated with vasculitis. Curr Opin Rheumatol 1998, 10:45-50.
3. Choi HK, Merkel PA, Walker AM, Niles JL. Drug-associated antineutrophil cytoplasmic antibody-positive vasculitis. Arthritis Rheum 2000, 43:405-13.
4. Yokogawa N, Vivino FB. Hydralazine-induced autoimmune disease: comparison to idiopathic lupus and ANCA-positive vasculitis. Mod Rheumatol 2009, 19:338-47.
5. Srivastava M, Rencic A, Diglio G. Drug-induced, Ro/SSA-positive cutaneous lupus erythematosus. Arch Dermatol 2003, 139:45-9.
6. Choi HK, Merkel PA, Niles JL. ANCA-positive vasculitis associated with allopurinol therapy. Clin Exp Rheumatol 1998, 16:743-4.
7. Slot CM, Links TP, Stegeman CA, Tervaert JWC. Occurrence of antineutrophil cytoplasmic antibodies and associated vasculitis in patients with hyperthyroidism treated with antithyroid drugs: a long-term followup study. Arthritis Care Res 2005, 53:108-13.
8. Haroon M, Devlin J. A case of ANCA-associated systemic vasculitis induced by atorvastatin. Clin Rheumatol 2008, 27:75-7.
9. Ridker P, Danielson E, Fonseca F. Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial. Lancet 2009, 373:1175-82.