Hydralazine-induced autoimmune disease: Comparison to idiopathic lupus and ANCA-positive vasculitis

Modern Rheumatology

Volumn 19, Issue 3, 2009, Pages 338-347

  Yokogawa, Naoto ^a   Vivino, Frederick B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Antineutrophil cytoplasmic antibody; Drug induced lupus erythematosus; Drug induced vasculitis; Hydralazine

Indexed keywords

ANTINUCLEAR ANTIBODY; CARDIOLIPIN ANTIBODY; CREATININE; CYCLOPHOSPHAMIDE; DNA ANTIBODY; DOUBLE STRANDED DNA ANTIBODY; GLOMERULUS BASEMENT MEMBRANE ANTIBODY; HISTONE ANTIBODY; HYDRALAZINE; HYDROCHLOROTHIAZIDE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; METHOTREXATE; MYELOPEROXIDASE; NEUTROPHIL CYTOPLASMIC ANTIBODY; PHOSPHOLIPID ANTIBODY; STEROID; WARFARIN;

ACROCYANOSIS; AGED; ANCA ASSOCIATED VASCULITIS; ANEMIA; ARTHRITIS; ARTICLE; AUTOIMMUNE DISEASE; CASE REPORT; CAUCASIAN; CREATININE BLOOD LEVEL; CYTOMEGALOVIRUS INFECTION; DIFFERENTIAL DIAGNOSIS; DRUG DOSE INCREASE; DRUG INDUCED DISEASE; DRUG MEGADOSE; DRUG WITHDRAWAL; ELECTRON MICROSCOPY; FEMALE; FINGER AMPUTATION; FOCAL GLOMERULONEPHRITIS; GANGRENE; HEMATURIA; HEMOPTYSIS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; HYDRALAZINE INDUCED PULMONARY RENAL SYNDROME; HYDRALAZINE INDUCED VASCULITIS; HYPERTENSION; HYPOCOMPLEMENTEMIA; IMMUNOFLUORESCENCE; KIDNEY BIOPSY; LIVEDO RETICULARIS; LUPUS ERYTHEMATOSUS NEPHRITIS; LUPUS LIKE SYNDROME; MALE; PLASMAPHERESIS; PRIORITY JOURNAL; PROLIFERATIVE GLOMERULONEPHRITIS; PROTEINURIA; RASH; SKIN BIOPSY; THORAX PAIN; THORAX RADIOGRAPHY;

AGED; AGED, 80 AND OVER; ANTIBODIES, ANTINEUTROPHIL CYTOPLASMIC; DIAGNOSIS, DIFFERENTIAL; FEMALE; HUMANS; HYDRALAZINE; LUPUS NEPHRITIS; MALE; VASCULITIS, HYPERSENSITIVITY; VASODILATOR AGENTS;

EID: 67349114151     PISSN: 14397595     EISSN: 14397609     Source Type: Journal    
DOI: 10.1007/s10165-009-0168-y     Document Type: Article

References (37)

1. Hoffman BJ. Sensitivity of sulfadiazine resembling acute disseminated lupus erythematosus. Arch Derm Syphilol. 1945;51:190-2.
2. Costa M, Said N, Zimmermann B. Drug-induced lupus due to anti-tumor necrosis factor α agents. Semin Arthritis Rheum. 2008;37:381-7.
3. Choi HK, Merkel PA, Walker AM, Niles JL. Drug-associated antineutrophil cytoplasmic antibody-positive vasculitis. Arthritis Rheum. 2000;43:405-13.
4. Wiik A. Drug-induced vasculitis. Curr Opin Rheumatol. 2008;20:35-9.
5. Morrow JD, Schroeder HA, Perry HM. Studies on the control of hypertension by Hyphex. Toxic reactions and side-effects. Circulation. 1953;8:829-39.
6. Yung RL, Richardson BC. Drug-induced lupus. Rheum Dis Clin North Am. 1994;20:61-84.
7. Bernstein RM, Egerton-Vernon J, Webster J. Hydralazine-induced cutaneous vasculitis. Br Med J. 1980;280:156-7.
8. Ludmerer KM, Kissane JM. Renal failure dyspnea and anemia in a 57 year old woman. Am J Med. 1981;71:876-86.
9. Björck S, Westberg G, Svalander C, Mulec H. Rapidly progressive glomerulonephritis after hydralazine. Lancet. 1983;2:42.
10. Nässberger L, Johansson AC, Björck S, Sjöholm AG. Antibodies to neutrophil granulocyte myeloperoxidase and elastase: autoimmune responses in glomerulonephritis due to hydralazine treatment. J Intern Med. 1991;229:261-5.
11. Peacock A, Weatherall D. Hydralazine-induced necrotizing vasculitis. Br Med J. 1981;282:1121-2.
12. Finlay AY, Statham B, Knight AG. Hydralazine-induced necrotizing vasculitis. Br Med J. 1981;282:1703-4.
13. Weiser G, Forouhar FA, White W. Hydralazine hoarseness. A new appearance of drug-induced systemic lupus erythematosus. Arch Intern Med. 1984;144:2271-2.
14. Cameron HA, Ramsay LE. The lupus syndrome induced by hydralazine: A common complication with low dose treatment. Br Med J. 1984;289:410-2.
15. Ihle BU, Whitworth JA, Dowling JP, Kincaid-Smith P. Hydralazine and lupus nephritis. Clin Nephrol. 1984;22:230-8.
16. Doherty M, Maddison PJ, Grey RH. Hydralazine induced lupus syndrome with eye disease. Br Med J. 1985;290:675.
17. Björck S, Svalander C, Westberg G. Hydralazine-associated glomerulonephritis. Acta Med Scand. 1985;218:261-9.
18. Mehrotra TN, Raka MS, Mithal R, Mehrotra A. Hydralazine induced necrotizing vasculitis. J Assoc Physicians India. 1986;34:502-3.
19. Martinez-Vea A, Ferrer I, Carcía C, Mayayo E, Oliver JA, Richart C. Systemic vasculitis resembling periarteritis nodosa in the lupus-like syndrome induced by hydralazine. Am J Nephrol. 1987;7:71-3.
20. Sturman SG, Kumararatne D, Beevers DG. Fatal hydralazine-induced systemic lupus erythematosus. Lancet. 1988;2:1304.
21. Almroth G, Eneström S, Hed J, Samuelsson I, Sjöström P. Autoantibodies to leukocyte antigens in hydralazine-associated nephritis. J Intern Med. 1992;231:37-42.
22. Cambridge G, Wallace H, Bernstein RM, Leaker B. Autoantibodies to myeloperoxidase in idiopathic and drug-induced systemic lupus erythematosus and vasculitis. Rheumatology. 1994;33:109-14.
23. Short AK, Lockwood CM. Antigen specificity in hydralazine associated ANCA positive systemic vasculitis. Q J Med. 1995;88:775-83.
24. Norris JH, Leeds J, Jeffrey RF. P-ANCA positive renal vasculitis in association with renal cell carcinoma and prolonged hydralazine therapy. Ren Fail. 2003;25:311-4.
25. Thakrar M, Pendharkar SR, Penney CJ, Hirani N. Hydralazine-induced pulmonary hemorrhage associated with a lupus anticoagulant. Chest. 2007;132:722S-3S.
26. Franssen C, Gans R, Kallenberg CK, Hagelken C, Hoortje S. Disease spectrum of patients with antineutrophil cytoplasmic autoantibodies of defined specificity: Distinct differences between patients with anti-proteinase 3 and anti-myeloperoxidase autoantibodies. J Intern Med. 1998;224:209-16.
27. Vasoo S. Drug induced lupus: An update. Lupus. 2006;15:757-61.
28. Sen D, Isenberg D. Antineutrophil cytoplasmic autoantibodies in systemic lupus erythematosus. Lupus. 2003;12:651-8.
29. Burlingame RW, Rubin RL. Drug-induced anti-histone autoantibodies display two patterns of reactivity with substructures of chromatin. J Clin Invest. 1991;88:680-90.
30. Portanova J, Arndt R, Kotzin BL. Anti-histone antibodies in idiopathic and drug-induced lupus recognize distinct intrahistone regions. J Immunol. 1987;138:446-51.
31. Torffvit Thysell H, Nässberger L. Occurrence of autoantibodies directed against myelooxidase and elastase in patients treated with hydralazine and presenting with glomerulonephritis. Hum Exp Toxicol. 1994;13:563-7.
32. Reidy TJ, Upshaw JDJ, Chesney TM. Propylthiouracil-induced vasculitis: Fatal case. South Med J. 1982;75:1297-8.
33. Pillinger M, Staud R. Wegener's Granulomatosis in a patient receiving Propylthiouracil for Grave's disease. Semin Arthritis Rheum. 1998;28:124-9.
34. Jiang X, Khursigara G, Rubin RL. Transformation of lupus-inducing drugs to cytotoxic products by activated neutrophils. Science. 1994;266:810-3.
35. Bonaci-Nikolic B, Nikolic MM, Andrejevic S, Zoric S, Bukilica M. Antineutrophil cytoplasmic antibody (ANCA)-associated autoimmune diseases induced by antithyroid drugs: Comparison with idiopathic ANCA vasculitides. Arthritis Res Ther. 2005;7:R1072-81.
36. Perry HM. Late toxicity to hydralazine resembling systemic lupus erythematosus or rheumatoid arthritis. Am J Med. 1973;54:58-72.
37. Vizjak A, Rott T, Koselj-Kajtna M, Rozman B, Kaplan-Pavlovcic S, Ferluga D. Histologic and immunohistologic study and clinical presentation of ANCA-associated glomerulonephritis with correlation to ANCA antigen specificity. Am J Kidney Dis. 2003;41:539-49.