Inhibition of glutamateglutamine cycle in vivo results in decreased benzodiazepine binding and differentially regulated GABAergic subunit expression in the rat brain

Epilepsia

Volumn 51, Issue 8, 2010, Pages 1446-1455

  Cremer, Christian M ^a,b   Bidmon, Hans Jürgen ^b   Görg, Boris ^b   Palomero Gallagher, Nicola ^a,b   Escobar, Jennifer Lopez ^a   Speckmann, Erwin Josef ^c   Zilles, Karl ^a,b  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Autoradiography; Benzodiazepine binding; GABAA; In situ hybridization; l Methionine sulfoximine; Neurotransmitter receptors

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR; ADENOSINE A1 RECEPTOR; AMPA RECEPTOR; BENZODIAZEPINE; DOPAMINE 1 RECEPTOR; EXCITATORY AMINO ACID TRANSPORTER; GLUTAMATE AMMONIA LIGASE; GLUTAMIC ACID; GLUTAMINE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; KAINIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROTRANSMITTER; NEUROTRANSMITTER RECEPTOR; RECEPTOR SUBTYPE; 4 AMINOBUTYRIC ACID RECEPTOR; AMINO ACID RECEPTOR BLOCKING AGENT; BENZODIAZEPINE DERIVATIVE; ENZYME INHIBITOR; MESSENGER RNA; METHIONINE SULFOXIMINE; PROTEIN SUBUNIT; TRITIUM;

4 AMINOBUTYRIC ACID METABOLISM; AMYGDALOID NUCLEUS; ANIMAL TISSUE; ARTICLE; ASTROCYTE; AUTORADIOGRAPHY; BINDING AFFINITY; BINDING SITE; BRAIN HOMOGENATE; CONTROLLED STUDY; ENTORHINAL CORTEX; EPILEPSY; GABAERGIC SYSTEM; GABAERGIC TRANSMISSION; GENE EXPRESSION; IN VIVO STUDY; MALE; NEUROMODULATION; NEUROTRANSMITTER RELEASE; NITRATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PYRIFORM CORTEX; RAT; SOMATOSENSORY CORTEX; WESTERN BLOTTING; ANIMAL; BRAIN; DRUG EFFECT; DRUG INTERACTION; GENETICS; HISTOLOGY; METABOLISM; METHODOLOGY; PROTEIN BINDING; TIME; WISTAR RAT;

ANIMALS; AUTORADIOGRAPHY; BENZODIAZEPINES; BINDING SITES; BRAIN; DRUG INTERACTIONS; ENZYME INHIBITORS; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMATE-AMMONIA LIGASE; GLUTAMIC ACID; GLUTAMINE; MALE; METHIONINE SULFOXIMINE; PROTEIN BINDING; PROTEIN SUBUNITS; RATS; RATS, WISTAR; RECEPTORS, GABA; RNA, MESSENGER; TIME FACTORS; TRITIUM;

EID: 77955325292     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2010.02562.x     Document Type: Article

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