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Volumn 363, Issue 6, 2010, Pages 552-563

Myocardial fibrosis as an early manifestation of hypertrophic cardiomyopathy

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TROPOMYOSIN; ANGIOTENSIN RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BIOLOGICAL MARKER; CALCIUM CHANNEL BLOCKING AGENT; CARBOXY TERMINAL TELOPEPTIDE; COLLAGEN; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DISOPYRAMIDE; GADOLINIUM PENTETATE; PROCOLLAGEN; SPIRONOLACTONE; TROPONIN T;

EID: 77955303165     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1002659     Document Type: Article
Times cited : (528)

References (49)
  • 1
    • 0035936792 scopus 로고    scopus 로고
    • The genetic basis for cardiomyopathy: From mutation identification to mechanistic paradigms
    • DOI 10.1016/S0092-8674(01)00242-2
    • Seidman JG, Seidman C. The genetic basis for cardiomyopathy: from mutation identification to mechanistic paradigms. Cell 2001;104:557-67. (Pubitemid 32201950)
    • (2001) Cell , vol.104 , Issue.4 , pp. 557-567
    • Seidman, J.G.1    Seidman, C.2
  • 3
    • 0029083650 scopus 로고
    • Prevalence of hypertrophic cardiomyopathy in a general population of young adults: Echocardiographic analysis of 4111 subjects in the CARDIA study
    • Maron BJ, Gardin JM, Flack JM, Gidding SS, Kurosaki TT, Bild DE. Prevalence of hypertrophic cardiomyopathy in a general population of young adults: echocardiographic analysis of 4111 subjects in the CARDIA study. Circulation 1995;92: 785-9.
    • (1995) Circulation , vol.92 , pp. 785-789
    • Maron, B.J.1    Gardin, J.M.2    Flack, J.M.3    Gidding, S.S.4    Kurosaki, T.T.5    Bild, D.E.6
  • 4
    • 4344705206 scopus 로고    scopus 로고
    • Proposal for contemporary screening strategies in families with hypertrophic cardiomyopathy
    • Maron BJ, Seidman JG, Seidman CE. Proposal for contemporary screening strategies in families with hypertrophic cardiomyopathy. J Am Coll Cardiol 2004; 44:2125-32.
    • (2004) J Am Coll Cardiol , vol.44 , pp. 2125-2132
    • Maron, B.J.1    Seidman, J.G.2    Seidman, C.E.3
  • 5
    • 0035838393 scopus 로고    scopus 로고
    • Tissue Doppler imaging consistently detects myocardial abnormalities in patients with hypertrophic cardiomyopathy and provides a novel means for an early diagnosis before and independently of hypertrophy
    • Nagueh SF, Bachinski LL, Meyer D, et al. Tissue Doppler imaging consistently detects myocardial abnormalities in patients with hypertrophic cardiomyopathy and provides a novel means for an early diagnosis before and independently of hypertrophy. Circulation 2001;104:128-30. (Pubitemid 32655824)
    • (2001) Circulation , vol.104 , Issue.2 , pp. 128-130
    • Nagueh, S.F.1    Bachinski, L.L.2    Meyer, D.3    Hill, R.4    Zoghbi, W.A.5    Tam, J.W.6    Quinones, M.A.7    Roberts, R.8    Marian, A.J.9
  • 6
    • 0037173015 scopus 로고    scopus 로고
    • Assessment of diastolic function with Doppler tissue imaging to predict genotype in preclinical hypertrophic cardiomyopathy
    • DOI 10.1161/01.CIR.0000019070.70491.6D
    • Ho CY, Sweitzer NK, McDonough B, et al. Assessment of diastolic function with Doppler tissue imaging to predict genotype in preclinical hypertrophic cardiomyopathy. Circulation 2002;105:2992-7. (Pubitemid 34693832)
    • (2002) Circulation , vol.105 , Issue.25 , pp. 2992-2997
    • Ho, C.Y.1    Sweitzer, N.K.2    McDonough, B.3    Maron, B.J.4    Casey, S.A.5    Seidman, J.G.6    Seidman, C.E.7    Solomon, S.D.8
  • 7
    • 75949106516 scopus 로고    scopus 로고
    • Echocardiographic strain imaging to assess early and late consequences of sarcomere mutations in hypertrophic cardiomyopathy
    • Ho CY, Carlsen C, Thune JJ, et al. Echocardiographic strain imaging to assess early and late consequences of sarcomere mutations in hypertrophic cardiomyopathy. Circ Cardiovasc Genet 2009; 2:314-21.
    • (2009) Circ Cardiovasc Genet , vol.2 , pp. 314-321
    • Ho, C.Y.1    Carlsen, C.2    Thune, J.J.3
  • 8
    • 0033863859 scopus 로고    scopus 로고
    • Hypertrophic cardiomyopathy and sudden death in the young: Pathologic evidence of myocardial ischemia
    • Basso C, Thiene G, Corrado D, Buja G, Melacini P, Nava A. Hypertrophic cardiomyopathy and sudden death in the young: pathologic evidence of myocardial ischemia. Hum Pathol 2000;31:988-98.
    • (2000) Hum Pathol , vol.31 , pp. 988-998
    • Basso, C.1    Thiene, G.2    Corrado, D.3    Buja, G.4    Melacini, P.5    Nava, A.6
  • 9
    • 0033972193 scopus 로고    scopus 로고
    • Morphology and significance of the left ventricular collagen network in young patients with hypertrophic cardiomyopathy and sudden cardiac death
    • Shirani J, Pick R, Roberts WC, Maron BJ. Morphology and significance of the left ventricular collagen network in young patients with hypertrophic cardiomyopathy and sudden cardiac death. J Am Coll Cardiol 2000;35:36-44.
    • (2000) J Am Coll Cardiol , vol.35 , pp. 36-44
    • Shirani, J.1    Pick, R.2    Roberts, W.C.3    Maron, B.J.4
  • 11
    • 0035423249 scopus 로고    scopus 로고
    • Relation between myocyte disarray and outcome in hypertrophic cardiomyopathy
    • DOI 10.1016/S0002-9149(01)01640-X, PII S000291490101640X
    • Varnava AM, Elliott PM, Mahon N, Davies MJ, McKenna WJ. Relation between myocyte disarray and outcome in hypertrophic cardiomyopathy. Am J Cardiol 2001;88:275-9. (Pubitemid 32721955)
    • (2001) American Journal of Cardiology , vol.88 , Issue.3 , pp. 275-279
    • Varnava, A.M.1    Elliott, P.M.2    Mahon, N.3    Davies, M.J.4    McKenna, W.J.5
  • 12
    • 0033769423 scopus 로고    scopus 로고
    • Hypertrophic cardiomyopathy: The interrelation of disarray, fibrosis, and small vessel disease
    • Varnava AM, Elliott PM, Sharma S, McKenna WJ, Davies MJ. Hypertrophic cardiomyopathy: the interrelation of disarray, fibrosis, and small vessel disease. Heart 2000;84:476-82.
    • (2000) Heart , vol.84 , pp. 476-482
    • Varnava, A.M.1    Elliott, P.M.2    Sharma, S.3    McKenna, W.J.4    Davies, M.J.5
  • 13
    • 0038076143 scopus 로고    scopus 로고
    • Toward clinical risk assessment in hypertrophic cardiomyopathy with gadolinium cardiovascular magnetic resonance
    • Moon JC, McKenna WJ, McCrohon JA, Elliott PM, Smith GC, Pennell DJ. Toward clinical risk assessment in hypertrophic cardiomyopathy with gadolinium cardiovascular magnetic resonance. J Am Coll Cardiol 2003;41:1561-7.
    • (2003) J Am Coll Cardiol , vol.41 , pp. 1561-1567
    • Moon, J.C.1    McKenna, W.J.2    McCrohon, J.A.3    Elliott, P.M.4    Smith, G.C.5    Pennell, D.J.6
  • 15
    • 62349134146 scopus 로고    scopus 로고
    • Clinical profile and significance of delayed enhancement in hypertrophic cardiomyopathy
    • Maron MS, Appelbaum E, Harrigan CJ, et al. Clinical profile and significance of delayed enhancement in hypertrophic cardiomyopathy. Circ Heart Fail 2008;1: 184-91.
    • (2008) Circ Heart Fail , vol.1 , pp. 184-191
    • Maron, M.S.1    Appelbaum, E.2    Harrigan, C.J.3
  • 16
    • 58149287871 scopus 로고    scopus 로고
    • Noninvasive detection of fibrosis applying contrast-enhanced cardiac magnetic resonance in different forms of left ventricular hypertrophy relation to remodeling
    • Rudolph A, Abdel-Aty H, Bohl S, et al. Noninvasive detection of fibrosis applying contrast-enhanced cardiac magnetic resonance in different forms of left ventricular hypertrophy relation to remodeling. J Am Coll Cardiol 2009;53:284-91.
    • (2009) J Am Coll Cardiol , vol.53 , pp. 284-291
    • Rudolph, A.1    Abdel-Aty, H.2    Bohl, S.3
  • 17
    • 33845338760 scopus 로고    scopus 로고
    • Structural Abnormalities of the Inferoseptal Left Ventricular Wall Detected by Cardiac Magnetic Resonance Imaging in Carriers of Hypertrophic Cardiomyopathy Mutations
    • DOI 10.1016/j.jacc.2006.08.036, PII S0735109706023515
    • Germans T, Wilde AA, Dijkmans PA, et al. Structural abnormalities of the inferoseptal left ventricular wall detected by cardiac magnetic resonance imaging in carriers of hypertrophic cardiomyopathy mutations. J Am Coll Cardiol 2006;48: 2518-23. (Pubitemid 44881223)
    • (2006) Journal of the American College of Cardiology , vol.48 , Issue.12 , pp. 2518-2523
    • Germans, T.1    Wilde, A.A.M.2    Dijkmans, P.A.3    Chai, W.4    Kamp, O.5    Pinto, Y.M.6    Van Rossum, A.C.7
  • 18
    • 23044514594 scopus 로고    scopus 로고
    • Myocardial late gadolinium enhancement cardiovascular magnetic resonance in hypertrophic cardiomyopathy caused by mutations in troponin I
    • DOI 10.1136/hrt.2004.041384
    • Moon JC, Mogensen J, Elliott PM, et al. Myocardial late gadolinium enhancement cardiovascular magnetic resonance in hypertrophic cardiomyopathy caused by mutations in troponin I. Heart 2005;91: 1036-40. (Pubitemid 41060010)
    • (2005) Heart , vol.91 , Issue.8 , pp. 1036-1040
    • Moon, J.C.1    Mogensen, J.2    Elliott, P.M.3    Smith, G.C.4    Elkington, A.G.5    Prasad, S.K.6    Penned, D.J.7    McKenna, W.J.8
  • 20
    • 34547111798 scopus 로고    scopus 로고
    • Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse alphacardiac myosin in the laser trap assay
    • Debold EP, Schmitt JP, Patlak JB, et al. Hypertrophic and dilated cardiomyopathy mutations differentially affect the molecular force generation of mouse alphacardiac myosin in the laser trap assay. Am J Physiol Heart Circ Physiol 2007;293: H284-H291.
    • (2007) Am J Physiol Heart Circ Physiol , vol.293
    • Debold, E.P.1    Schmitt, J.P.2    Patlak, J.B.3
  • 21
    • 64549096033 scopus 로고    scopus 로고
    • Resolution of established cardiac hypertrophy and fibrosis and prevention of systolic dysfunction in a transgenic rabbit model of human cardiomyopathy through thiol-sensitive mechanisms
    • Lombardi R, Rodriguez G, Chen SN, et al. Resolution of established cardiac hypertrophy and fibrosis and prevention of systolic dysfunction in a transgenic rabbit model of human cardiomyopathy through thiol-sensitive mechanisms. Circulation 2009;119:1398-407.
    • (2009) Circulation , vol.119 , pp. 1398-1407
    • Lombardi, R.1    Rodriguez, G.2    Chen, S.N.3
  • 22
    • 30944444021 scopus 로고    scopus 로고
    • Sarcomeric proteins and familial hypertrophic cardiomyopathy: Linking mutations in structural proteins to complex cardiovascular phenotypes
    • Tardiff JC. Sarcomeric proteins and familial hypertrophic cardiomyopathy: linking mutations in structural proteins to complex cardiovascular phenotypes. Heart Fail Rev 2005;10:237-48.
    • (2005) Heart Fail Rev , vol.10 , pp. 237-248
    • Tardiff, J.C.1
  • 23
    • 33847231568 scopus 로고    scopus 로고
    • Coronary microvascular dysfunction
    • Camici PG, Crea F. Coronary microvascular dysfunction. N Engl J Med 2007; 356:830-40.
    • (2007) N Engl J Med , vol.356 , pp. 830-840
    • Camici, P.G.1    Crea, F.2
  • 26
    • 59449103786 scopus 로고    scopus 로고
    • Biochemical markers of myocardial remodelling in hypertensive heart disease
    • González A, López B, Ravassa S, et al. Biochemical markers of myocardial remodelling in hypertensive heart disease. Cardiovasc Res 2009;81:509-18.
    • (2009) Cardiovasc Res , vol.81 , pp. 509-518
    • González, A.1    López, B.2    Ravassa, S.3
  • 27
    • 4444229005 scopus 로고    scopus 로고
    • Increased collagen type I synthesis in patients with heart failure of hypertensive origin: Relation to myocardial fibrosis
    • Querejeta R, López B, González A, et al. Increased collagen type I synthesis in patients with heart failure of hypertensive origin: relation to myocardial fibrosis. Circulation 2004;110:1263-8.
    • (2004) Circulation , vol.110 , pp. 1263-1268
    • Querejeta, R.1    López, B.2    González, A.3
  • 28
    • 0028920377 scopus 로고
    • Measuring extracellular matrix turnover in the serum of patients with idiopathic or ischemic dilated cardiomyopathy and impact on diagnosis and prognosis
    • Klappacher G, Franzen P, Haab D, et al. Measuring extracellular matrix turnover in the serum of patients with idiopathic or ischemic dilated cardiomyopathy and impact on diagnosis and prognosis. Am J Cardiol 1995;75:913-8.
    • (1995) Am J Cardiol , vol.75 , pp. 913-918
    • Klappacher, G.1    Franzen, P.2    Haab, D.3
  • 29
    • 17944382123 scopus 로고    scopus 로고
    • Long-term changes in collagen formation expressed by serum carboxyterminal propeptide of type-I procollagen and relation to left ventricular function after acute myocardial infarction
    • DOI 10.1159/000047385
    • Poulsen SH, Host NB, Egstrup K. Long-term changes in collagen formation expressed by serum carboxyterminal propeptide of type-I procollagen and relation to left ventricular function after acute myocardial infarction. Cardiology 2001; 96:45-50. (Pubitemid 33035957)
    • (2001) Cardiology , vol.96 , Issue.1 , pp. 45-50
    • Poulsen, S.H.1    Host, N.B.2    Egstrup, K.3
  • 30
    • 0034727695 scopus 로고    scopus 로고
    • Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: Insights from the Randomized Aldactone Evaluation Study (RALES)
    • Zannad F, Alla F, Dousset B, Perez A, Pitt B. Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the Randomized Aldactone Evaluation Study (RALES). Circulation 2000;102:2700-6.
    • (2000) Circulation , vol.102 , pp. 2700-2706
    • Zannad, F.1    Alla, F.2    Dousset, B.3    Perez, A.4    Pitt, B.5
  • 32
    • 18844414847 scopus 로고    scopus 로고
    • Elevated serum markers for collagen synthesis in patients with hypertrophic cardiomyopathy and diastolic dysfunction
    • DOI 10.1007/s00392-005-0214-5
    • Fassbach M, Schwartzkopff B. Elevated serum markers for collagen synthesis in patients with hypertrophic cardiomyopathy and diastolic dysfunction. Z Kardiol 2005;94:328-35. (Pubitemid 40684969)
    • (2005) Zeitschrift fur Kardiologie , vol.94 , Issue.5 , pp. 328-335
    • Fassbach, M.1    Schwartzkopff, B.2
  • 35
    • 23044454596 scopus 로고    scopus 로고
    • Theoretical and empirical derivation of cardiovascular allometric relationships in children
    • DOI 10.1152/japplphysiol.01144.2004
    • Sluysmans T, Colan SD. Theoretical and empirical derivation of cardiovascular allometric relationships in children. J Appl Physiol 2005;99:445-57. (Pubitemid 41061136)
    • (2005) Journal of Applied Physiology , vol.99 , Issue.2 , pp. 445-457
    • Sluysmans, T.1    Colan, S.D.2
  • 36
    • 0031049263 scopus 로고    scopus 로고
    • Experience from clinical genetics in hypertrophic cardiomyopathy: Proposal for new diagnostic criteria in adult members of affected families
    • McKenna WJ, Spirito P, Desnos M, Dubourg O, Komajda M. Experience from clinical genetics in hypertrophic cardiomyopathy: proposal for new diagnostic criteria in adult members of affected families. Heart 1997;77:130-2. (Pubitemid 27115795)
    • (1997) Heart , vol.77 , Issue.2 , pp. 130-132
    • McKenna, W.J.1    Spirito, P.2    Desnos, M.3    Dubourg, O.4    Komajda, M.5
  • 37
    • 29244432482 scopus 로고    scopus 로고
    • Recommendations for chamber quantification: A report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology
    • Lang RM, Bierig M, Devereux RB, et al. Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 2005;18: 1440-63.
    • (2005) J Am Soc Echocardiogr , vol.18 , pp. 1440-1463
    • Lang, R.M.1    Bierig, M.2    Devereux, R.B.3
  • 38
    • 0034633812 scopus 로고    scopus 로고
    • Clinical utility of Doppler echocardiography and tissue Doppler imaging in the estimation of left ventricular filling pressures: A comparative simultaneous Doppler-catheterization study
    • Ommen SR, Nishimura RA, Appleton CP, et al. Clinical utility of Doppler echocardiography and tissue Doppler imaging in the estimation of left ventricular filling pressures: a comparative simultaneous Doppler- catheterization study. Circulation 2000;102:1788-94.
    • (2000) Circulation , vol.102 , pp. 1788-1794
    • Ommen, S.R.1    Nishimura, R.A.2    Appleton, C.P.3
  • 39
    • 0036738248 scopus 로고    scopus 로고
    • Can left ventricular diastolic stiffness be measured noninvasively?
    • Marino P, Little WC, Rossi A, et al. Can left ventricular diastolic stiffness be measured noninvasively? J Am Soc Echocardiogr 2002;15:935-43.
    • (2002) J Am Soc Echocardiogr , vol.15 , pp. 935-943
    • Marino, P.1    Little, W.C.2    Rossi, A.3
  • 41
    • 0036642629 scopus 로고    scopus 로고
    • Comparison of interstudy reproducibility of cardiovascular magnetic resonance with two-dimensional echocardiography in normal subjects and in patients with heart failure or left ventricular hypertrophy
    • DOI 10.1016/S0002-9149(02)02381-0, PII S0002914902023810
    • Grothues F, Smith GC, Moon JC, et al. Comparison of interstudy reproducibility of cardiovascular magnetic resonance with two-dimensional echocardiography in normal subjects and in patients with heart failure or left ventricular hypertrophy. Am J Cardiol 2002;90:29-34. (Pubitemid 34671198)
    • (2002) American Journal of Cardiology , vol.90 , Issue.1 , pp. 29-34
    • Grothues, F.1    Smith, G.C.2    Moon, J.C.C.3    Bellenger, N.G.4    Collins, P.5    Klein, H.U.6    Pennell, D.J.7
  • 42
    • 0033539584 scopus 로고    scopus 로고
    • Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function
    • Kim RJ, Fieno DS, Parrish TB, et al. Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function. Circulation 1999;100:1992-2002.
    • (1999) Circulation , vol.100 , pp. 1992-2002
    • Kim, R.J.1    Fieno, D.S.2    Parrish, T.B.3
  • 43
    • 0025837681 scopus 로고
    • Serum concentrations of the type I and III procollagen propeptides as biochemical markers of growth velocity in healthy infants and children and in children with growth disorders
    • Trivedi P, Risteli J, Risteli L, Hindmarsh PC, Brook CG, Mowat AP. Serum concentrations of the type I and III procollagen propeptides as biochemical markers of growth velocity in healthy infants and children and in children with growth disorders. Pediatr Res 1991;30:276-80.
    • (1991) Pediatr Res , vol.30 , pp. 276-280
    • Trivedi, P.1    Risteli, J.2    Risteli, L.3    Hindmarsh, P.C.4    Brook, C.G.5    Mowat, A.P.6
  • 44
    • 77950940268 scopus 로고    scopus 로고
    • Circulating biomarkers of collagen metabolism in cardiac diseases
    • López B, González A, Díez J. Circulating biomarkers of collagen metabolism in cardiac diseases. Circulation 2010;121: 1645-54.
    • (2010) Circulation , vol.121 , pp. 1645-1654
    • López, B.1    González, A.2    Díez, J.3
  • 45
    • 0035814656 scopus 로고    scopus 로고
    • Visualisation of presence, location, and transmural extent of healed Q-wave and non-Q-wave myocardial infarction
    • DOI 10.1016/S0140-6736(00)03567-4
    • Wu E, Judd RM, Vargas JD, Klocke FJ, Bonow RO, Kim RJ. Visualisation of presence, location, and transmural extent of healed Q-wave and non-Q-wave myocardial infarction. Lancet 2001;357:21-8. (Pubitemid 32056497)
    • (2001) Lancet , vol.357 , Issue.9249 , pp. 21-28
    • Wu, E.1    Judd, R.M.2    Vargas, J.D.3    Klocke, F.J.4    Bonow, R.O.5    Kim, R.J.6
  • 46
    • 0035849545 scopus 로고    scopus 로고
    • Visualization of discrete microinfarction after percutaneous coronary intervention associated with mild creatine kinase-MB elevation
    • Ricciardi MJ, Wu E, Davidson CJ, et al. Visualization of discrete microinfarction after percutaneous coronary intervention associated with mild creatine kinase-MB elevation. Circulation 2001;103:2780-3. (Pubitemid 32550063)
    • (2001) Circulation , vol.103 , Issue.23 , pp. 2780-2783
    • Ricciardi, M.J.1    Wu, E.2    Davidson, C.J.3    Choi, K.M.4    Klocke, F.J.5    Bonow, R.O.6    Judd, R.M.7    Kim, R.J.8
  • 47
    • 60349089919 scopus 로고    scopus 로고
    • ECG quantification of myocardial scar in cardiomyopathy patients with or without conduction defects: Correlation with cardiac magnetic resonance and arrhythmogenesis
    • Strauss DG, Selvester RH, Lima JA, et al. ECG quantification of myocardial scar in cardiomyopathy patients with or without conduction defects: correlation with cardiac magnetic resonance and arrhythmogenesis. Circ Arrhythm Electrophysiol 2008;1:327-36.
    • (2008) Circ Arrhythm Electrophysiol , vol.1 , pp. 327-336
    • Strauss, D.G.1    Selvester, R.H.2    Lima, J.A.3
  • 48
    • 0032580520 scopus 로고    scopus 로고
    • Mutations in the gene for cardiac myosin-binding protein C and late-onset familial hypertrophic cardiomyopathy
    • Niimura H, Bachinski LL, Sangwatanaroj S, et al. Mutations in the gene for cardiac myosin-binding protein C and late-onset familial hypertrophic cardiomyopathy. N Engl J Med 1998;338:1248-57.
    • (1998) N Engl J Med , vol.338 , pp. 1248-1257
    • Niimura, H.1    Bachinski, L.L.2    Sangwatanaroj, S.3


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