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Volumn 78, Issue 8, 2010, Pages 3346-3357

Role of the membrane localization domain of the Pseudomonas aeruginosa effector protein ExoU in cytotoxicity

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; COPPER ZINC SUPEROXIDE DISMUTASE; PHOSPHOLIPASE A2; PROTEIN EXOU; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; PSEUDOMONAS EXOPROTEIN A PROTEIN, PSEUDOMONAS AERUGINOSA; SIGNAL PEPTIDE; VIRULENCE FACTOR;

EID: 77955302592     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00223-10     Document Type: Article
Times cited : (32)

References (39)
  • 1
    • 33644825538 scopus 로고    scopus 로고
    • ExoS of Pseudomonas aeruginosa induces apoptosis through a Fas receptor/caspase 8-independent pathway in HeLa cells
    • Alaoui-El-Azher, M., J. Jia, W. Lian, and S. Jin. 2006. ExoS of Pseudomonas aeruginosa induces apoptosis through a Fas receptor/caspase 8-independent pathway in HeLa cells. Cell. Microbiol. 8:326-338.
    • (2006) Cell. Microbiol. , vol.8 , pp. 326-338
    • Alaoui-El-Azher, M.1    Jia, J.2    Lian, W.3    Jin, S.4
  • 2
    • 0034868647 scopus 로고    scopus 로고
    • ADP-ribosylation of Rab5 by ExoS of Pseudomonas aeruginosa affects endocytosis
    • Barbieri, A. M., Q. Sha, P. Bette-Bobillo, P. D. Stahl, and M. Vidal. 2001. ADP-ribosylation of Rab5 by ExoS of Pseudomonas aeruginosa affects endocytosis. Infect. Immun. 69:5329-5334.
    • (2001) Infect. Immun. , vol.69 , pp. 5329-5334
    • Barbieri, A.M.1    Sha, Q.2    Bette-Bobillo, P.3    Stahl, P.D.4    Vidal, M.5
  • 4
    • 72449131834 scopus 로고    scopus 로고
    • A sensitive fluorescence- based assay for the detection of ExoU-mediated PLA(2) activity
    • Benson, M. A., K. M. Schmalzer, and D. W. Frank. 2010. A sensitive fluorescence- based assay for the detection of ExoU-mediated PLA(2) activity. Clin. Chim Acta 411:190-197.
    • (2010) Clin. Chim Acta , vol.411 , pp. 190-197
    • Benson, M.A.1    Schmalzer, K.M.2    Frank, D.W.3
  • 5
    • 0025809268 scopus 로고
    • Pseudomonas aeruginosa exoenzyme S requires a eukaryotic protein for ADP-ribosyltransferase activity
    • Coburn, J., A. V. Kane, L. Feig, and D. M. Gill. 1991. Pseudomonas aeruginosa exoenzyme S requires a eukaryotic protein for ADP-ribosyltransferase activity. J. Biol. Chem. 266:6438-6446.
    • (1991) J. Biol. Chem. , vol.266 , pp. 6438-6446
    • Coburn, J.1    Kane, A.V.2    Feig, L.3    Gill, D.M.4
  • 6
    • 0024356764 scopus 로고
    • Several GTP-binding proteins, including p21c-H-ras, are preferred substrates of Pseudomonas aeruginosa exoenzyme S
    • Coburn, J., R. T. Wyatt, B. H. Iglewski, and D. M. Gill. 1989. Several GTP-binding proteins, including p21c-H-ras, are preferred substrates of Pseudomonas aeruginosa exoenzyme S. J. Biol. Chem. 264:9004-9008.
    • (1989) J. Biol. Chem. , vol.264 , pp. 9004-9008
    • Coburn, J.1    Wyatt, R.T.2    Iglewski, B.H.3    Gill, D.M.4
  • 7
    • 0032968052 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa gene products PilT and PilU are required for cytotoxicity in vitro and virulence in a mouse model of acute pneumonia
    • Comolli, J. C., A. R. Hauser, L. Waite, C. B. Whitchurch, J. S. Mattick, and J. N. Engel. 1999. Pseudomonas aeruginosa gene products PilT and PilU are required for cytotoxicity in vitro and virulence in a mouse model of acute pneumonia. Infect. Immun. 67:3625-3630.
    • (1999) Infect. Immun. , vol.67 , pp. 3625-3630
    • Comolli, J.C.1    Hauser, A.R.2    Waite, L.3    Whitchurch, C.B.4    Mattick, J.S.5    Engel, J.N.6
  • 9
    • 0034769748 scopus 로고    scopus 로고
    • Prevalence of type III secretion genes in clinical and environmental isolates of Pseudomonas aeruginosa
    • Feltman, H., G. Schulert, S. Khan, M. Jain, L. Peterson, and A. R. Hauser. 2001. Prevalence of type III secretion genes in clinical and environmental isolates of Pseudomonas aeruginosa. Microbiology 147:2659-2669. (Pubitemid 32976307)
    • (2001) Microbiology , vol.147 , Issue.10 , pp. 2659-2669
    • Feltman, H.1    Schulert, G.2    Khan, S.3    Jain, M.4    Peterson, L.5    Hauser, A.R.6
  • 10
    • 0034977803 scopus 로고    scopus 로고
    • Multiple domains are required for the toxic activity of Pseudomonas aeruginosa ExoU
    • DOI 10.1128/JB.183.14.4330-4344.2001
    • Finck-Barbancon, V., and D. W. Frank. 2001. Multiple domains are required for the toxic activity of Pseudomonas aeruginosa ExoU. J. Bacteriol. 183: 4330-4344. (Pubitemid 32568086)
    • (2001) Journal of Bacteriology , vol.183 , Issue.14 , pp. 4330-4344
    • Finck-Barbancon, V.1    Frank, D.W.2
  • 12
    • 0030726075 scopus 로고    scopus 로고
    • The exoenzyme S regulon of Pseudomonas aeruginosa
    • Frank, D. W. 1997. The exoenzyme S regulon of Pseudomonas aeruginosa. Mol. Microbiol. 26:621-629.
    • (1997) Mol. Microbiol. , vol.26 , pp. 621-629
    • Frank, D.W.1
  • 13
    • 0032571385 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa exoenzyme S ADP-ribosylates Ras at multiple sites
    • Ganesan, A. K., D. W. Frank, R. P. Misra, G. Schmidt, and J. T. Barbieri. 1998. Pseudomonas aeruginosa exoenzyme S ADP-ribosylates Ras at multiple sites. J. Biol. Chem. 273:7332-7337.
    • (1998) J. Biol. Chem. , vol.273 , pp. 7332-7337
    • Ganesan, A.K.1    Frank, D.W.2    Misra, R.P.3    Schmidt, G.4    Barbieri, J.T.5
  • 14
    • 69249157248 scopus 로고    scopus 로고
    • The type III secretion system of Pseudomonas aeruginosa: Infection by injection
    • Hauser, A. R. 2009. The type III secretion system of Pseudomonas aeruginosa: infection by injection. Nat. Rev. Microbiol. 7:654-665.
    • (2009) Nat. Rev. Microbiol. , vol.7 , pp. 654-665
    • Hauser, A.R.1
  • 15
    • 0031917203 scopus 로고    scopus 로고
    • PepA, a secreted protein of Pseudomonas aeruginosa, is necessary for cytotoxicity and virulence
    • Hauser, A. R., P. J. Kang, and J. N. Engel. 1998. PepA, a secreted protein of Pseudomonas aeruginosa, is necessary for cytotoxicity and virulence. Mol. Microbiol. 27:807-818.
    • (1998) Mol. Microbiol. , vol.27 , pp. 807-818
    • Hauser, A.R.1    Kang, P.J.2    Engel, J.N.3
  • 16
    • 0034254837 scopus 로고    scopus 로고
    • 14-3-3 proteins are required for the inhibition of Ras by exoenzyme S
    • Henriksson, M. L., U. Troller, and B. Hallberg. 2000. 14-3-3 proteins are required for the inhibition of Ras by exoenzyme S. Biochem. J. 349 Pt. 3:697-701.
    • (2000) Biochem. J. , vol.349 , Issue.PART 3 , pp. 697-701
    • Henriksson, M.L.1    Troller, U.2    Hallberg, B.3
  • 17
    • 0033968474 scopus 로고    scopus 로고
    • Integration- proficient plasmids for Pseudomonas aeruginosa: Site-specific integration and use for engineering of reporter and expression strains
    • Hoang, T. T., A. J. Kutchma, A. Becher, and H. P. Schweizer. 2000. Integration- proficient plasmids for Pseudomonas aeruginosa: site-specific integration and use for engineering of reporter and expression strains. Plasmid 43:59-72.
    • (2000) Plasmid , vol.43 , pp. 59-72
    • Hoang, T.T.1    Kutchma, A.J.2    Becher, A.3    Schweizer, H.P.4
  • 18
    • 0033753988 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa mediated apoptosis requires the ADP-ribosylating activity of ExoS
    • Kaufman, M. R., J. Jia, L. Zeng, U. Ha, M. Chow, and S. Jin. 2000. Pseudomonas aeruginosa mediated apoptosis requires the ADP-ribosylating activity of ExoS. Microbiology 146:2531-2541.
    • (2000) Microbiology , vol.146 , pp. 2531-2541
    • Kaufman, M.R.1    Jia, J.2    Zeng, L.3    Ha, U.4    Chow, M.5    Jin, S.6
  • 19
    • 15544380187 scopus 로고    scopus 로고
    • Activities of Pseudomonas aeruginosa effectors secreted by the type III secretion system in vitro and during infection
    • Lee, V. T., R. S. Smith, B. Tummler, and S. Lory. 2005. Activities of Pseudomonas aeruginosa effectors secreted by the type III secretion system in vitro and during infection. Infect. Immun. 73:1695-1705.
    • (2005) Infect. Immun. , vol.73 , pp. 1695-1705
    • Lee, V.T.1    Smith, R.S.2    Tummler, B.3    Lory, S.4
  • 20
    • 0021809838 scopus 로고
    • The contribution of exoproducts to virulence of Pseudomonas aeruginosa
    • Nicas, T. I., and B. H. Iglewski. 1985. The contribution of exoproducts to virulence of Pseudomonas aeruginosa. Can. J. Microbiol. 31:387-392.
    • (1985) Can. J. Microbiol. , vol.31 , pp. 387-392
    • Nicas, T.I.1    Iglewski, B.H.2
  • 21
    • 0021257575 scopus 로고
    • Isolation and characterization of transposon-induced mutants of Pseudomonas aeruginosa deficient in production of exoenzyme S
    • Nicas, T. I., and B. H. Iglewski. 1984. Isolation and characterization of transposon-induced mutants of Pseudomonas aeruginosa deficient in production of exoenzyme S. Infect. Immun. 45:470-474.
    • (1984) Infect. Immun. , vol.45 , pp. 470-474
    • Nicas, T.I.1    Iglewski, B.H.2
  • 23
    • 0142135037 scopus 로고    scopus 로고
    • In vivo phospholipase activity of the Pseudomonas aeruginosa cytotoxin ExoU and protection of mammalian cells with phospholipase A2 inhibitors
    • Phillips, R. M., D. A. Six, E. A. Dennis, and P. Ghosh. 2003. In vivo phospholipase activity of the Pseudomonas aeruginosa cytotoxin ExoU and protection of mammalian cells with phospholipase A2 inhibitors. J. Biol. Chem. 278:41326-41332.
    • (2003) J. Biol. Chem. , vol.278 , pp. 41326-41332
    • Phillips, R.M.1    Six, D.A.2    Dennis, E.A.3    Ghosh, P.4
  • 24
    • 27444434285 scopus 로고    scopus 로고
    • Application of vaccine technology to prevention of Pseudomonas aeruginosa infections
    • DOI 10.1586/14760584.4.5.645
    • Pier, G. 2005. Application of vaccine technology to prevention of Pseudomonas aeruginosa infections. Expert Rev. Vaccines 4:645-656. (Pubitemid 41530588)
    • (2005) Expert Review of Vaccines , vol.4 , Issue.5 , pp. 645-656
    • Pier, G.1
  • 25
    • 11144265658 scopus 로고    scopus 로고
    • Functional regions of the Pseudomonas aeruginosa cytotoxin ExoU
    • Rabin, S. D., and A. R. Hauser. 2005. Functional regions of the Pseudomonas aeruginosa cytotoxin ExoU. Infect. Immun. 73:573-582.
    • (2005) Infect. Immun. , vol.73 , pp. 573-582
    • Rabin, S.D.1    Hauser, A.R.2
  • 26
    • 0037634093 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa ExoU, a toxin transported by the type III secretion system, kills Saccharomyces cerevisiae
    • Rabin, S. D., and A. R. Hauser. 2003. Pseudomonas aeruginosa ExoU, a toxin transported by the type III secretion system, kills Saccharomyces cerevisiae. Infect. Immun. 71:4144-4150.
    • (2003) Infect. Immun. , vol.71 , pp. 4144-4150
    • Rabin, S.D.1    Hauser, A.R.2
  • 27
    • 33646374906 scopus 로고    scopus 로고
    • A C-terminal domain targets the Pseudomonas aeruginosa cytotoxin ExoU to the plasma membrane of host cells
    • Rabin, S. D., J. L. Veesenmeyer, K. T. Bieging, and A. R. Hauser. 2006. A C-terminal domain targets the Pseudomonas aeruginosa cytotoxin ExoU to the plasma membrane of host cells. Infect. Immun. 74:2552-2561.
    • (2006) Infect. Immun. , vol.74 , pp. 2552-2561
    • Rabin, S.D.1    Veesenmeyer, J.L.2    Bieging, K.T.3    Hauser, A.R.4
  • 28
    • 33748672064 scopus 로고    scopus 로고
    • Identification of superoxide dismutase as a cofactor for the Pseudomonas type III toxin, ExoU
    • DOI 10.1021/bi060788j
    • Sato, H., J. B. Feix, and D. W. Frank. 2006. Identification of superoxide dismutase as a cofactor for the pseudomonas type III toxin, ExoU. Biochemistry 45:10368-10375. (Pubitemid 44384812)
    • (2006) Biochemistry , vol.45 , Issue.34 , pp. 10368-10375
    • Sato, H.1    Feix, J.B.2    Frank, D.W.3
  • 29
    • 13244295376 scopus 로고    scopus 로고
    • Characterization of phospholipase activity of the Pseudomonas aeruginosa type III cytotoxin, ExoU
    • DOI 10.1128/JB.187.3.1192-1195.2005
    • Sato, H., J. B. Feix, C. J. Hillard, and D. W. Frank. 2005. Characterization of phospholipase activity of the Pseudomonas aeruginosa type III cytotoxin, ExoU. J. Bacteriol. 187:1192-1195. (Pubitemid 40189790)
    • (2005) Journal of Bacteriology , vol.187 , Issue.3 , pp. 1192-1195
    • Sato, H.1    Feix, J.B.2    Hillard, C.J.3    Frank, D.W.4
  • 30
    • 4444342607 scopus 로고    scopus 로고
    • ExoU is a potent intracellular phospholipase
    • Sato, H., and D. W. Frank. 2004. ExoU is a potent intracellular phospholipase. Mol. Microbiol. 53:1279-1290.
    • (2004) Mol. Microbiol. , vol.53 , pp. 1279-1290
    • Sato, H.1    Frank, D.W.2
  • 32
    • 77949694407 scopus 로고    scopus 로고
    • Activation of ExoU phospholipase activity requires specific C-terminal regions
    • Schmalzer, K. M., M. A. Benson, and D. W. Frank. 2010. Activation of ExoU phospholipase activity requires specific C-terminal regions. J. Bacteriol. 192: 1801-1812.
    • (2010) J. Bacteriol. , vol.192 , pp. 1801-1812
    • Schmalzer, K.M.1    Benson, M.A.2    Frank, D.W.3
  • 33
    • 0346256754 scopus 로고    scopus 로고
    • Secretion of the toxin ExoU is a marker for highly virulent Pseudomonas aeruginosa isolates obtained from patients with hospital- acquired pneumonia
    • Schulert, G. S., H. Feltman, S. D. Rabin, C. G. Martin, S. E. Battle, J. Rello, and A. R. Hauser. 2003. Secretion of the toxin ExoU is a marker for highly virulent Pseudomonas aeruginosa isolates obtained from patients with hospital- acquired pneumonia. J. Infect. Dis. 188:1695-1706.
    • (2003) J. Infect. Dis. , vol.188 , pp. 1695-1706
    • Schulert, G.S.1    Feltman, H.2    Rabin, S.D.3    Martin, C.G.4    Battle, S.E.5    Rello, J.6    Hauser, A.R.7
  • 34
    • 9244236027 scopus 로고    scopus 로고
    • Relative contributions of Pseudomonas aeruginosa ExoU, ExoS, and ExoT to virulence in the lung
    • Shaver, C. M., and A. R. Hauser. 2004. Relative contributions of Pseudomonas aeruginosa ExoU, ExoS, and ExoT to virulence in the lung. Infect. Immun. 72:6969-6977.
    • (2004) Infect. Immun. , vol.72 , pp. 6969-6977
    • Shaver, C.M.1    Hauser, A.R.2
  • 35
    • 33745621121 scopus 로고    scopus 로고
    • Eukaryotic localization, activation and ubiquitinylation of a bacterial type III secreted toxin
    • Stirling, F. R., A. Cuzick, S. M. Kelly, D. Oxley, and T. J. Evans. 2006. Eukaryotic localization, activation and ubiquitinylation of a bacterial type III secreted toxin. Cell. Microbiol. 8:1294-1309.
    • (2006) Cell. Microbiol. , vol.8 , pp. 1294-1309
    • Stirling, F.R.1    Cuzick, A.2    Kelly, S.M.3    Oxley, D.4    Evans, T.J.5
  • 36
    • 0041355556 scopus 로고    scopus 로고
    • Pseudomonas aeruginosa ExoT ADPribosylates CT10 regulator of kinase (Crk) proteins
    • Sun, J., and J. T. Barbieri. 2003. Pseudomonas aeruginosa ExoT ADPribosylates CT10 regulator of kinase (Crk) proteins. J. Biol. Chem. 278: 32794-32800.
    • (2003) J. Biol. Chem. , vol.278 , pp. 32794-32800
    • Sun, J.1    Barbieri, J.T.2
  • 37
    • 0033066577 scopus 로고    scopus 로고
    • Biological effects of Pseudomonas aeruginosa type III-secreted proteins on CHO cells
    • Vallis, A. J., V. Finck-Barbancon, T. L. Yahr, and D. W. Frank. 1999. Biological effects of Pseudomonas aeruginosa type III-secreted proteins on CHO cells. Infect. Immun. 67:2040-2044.
    • (1999) Infect. Immun. , vol.67 , pp. 2040-2044
    • Vallis, A.J.1    Finck-Barbancon, V.2    Yahr, T.L.3    Frank, D.W.4
  • 39
    • 0029898894 scopus 로고    scopus 로고
    • Protein prenylation: Molecular mechanisms and functional consequences
    • Zhang, F. L., and P. J. Casey. 1996. Protein prenylation: molecular mechanisms and functional consequences. Annu. Rev. Biochem. 65:241-269.
    • (1996) Annu. Rev. Biochem. , vol.65 , pp. 241-269
    • Zhang, F.L.1    Casey, P.J.2


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