Deleted in Breast Cancer 1 (DBC1) is a dynamically regulated protein

Neoplasma

Volumn 57, Issue 4, 2010, Pages 365-368

  Kim, J E ^a   Sung, S ^a  

^a Kyung Hee University Hospital   (South Korea)

Author keywords

Cancer; DBC1; SIRT1; Tumor promoter; Tumor suppressor

Indexed keywords

DELETED IN BREAST CANCER 1; PEPTIDES AND PROTEINS; UNCLASSIFIED DRUG; DBC1 PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; BREAST CANCER; CANCER CELL; CELL CYCLE REGULATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; LUNG CANCER; LUNG FIBROBLAST; OLIGOMERIZATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; BREAST; BREAST TUMOR; CELL CULTURE; CELL CYCLE; COMPARATIVE STUDY; CYTOLOGY; FEMALE; FIBROBLAST; IMMUNOPRECIPITATION; LUNG; LUNG TUMOR; METABOLISM; PATHOLOGY; PROTEIN MULTIMERIZATION;

BREAST; BREAST NEOPLASMS; CELL CYCLE; CELLS, CULTURED; FEMALE; FIBROBLASTS; HUMANS; IMMUNOPRECIPITATION; LUNG; LUNG NEOPLASMS; PROTEIN MULTIMERIZATION; TUMOR SUPPRESSOR PROTEINS;

EID: 77955294403     PISSN: 00282685     EISSN: None     Source Type: Journal    
DOI: 10.4149/neo_2010_04_365     Document Type: Article

References (17)

1. KIM JE, CHEN J, LOU Z DBC1 is a negative regulator of SIRT1. Nature 2008; 451: 583-586. doi:10.1038/nature06500
2. ZHAO W, KRUSE JP, TANG Y, JUNG SY, QIN J et al. Negative regulation of the deacetylase SIRT1 by DBC1. Nature 2008; 451: 587-590. doi:10.1038/nature06515
3. TRAUERNICHT AM, KIM SJ, KIM NH, BOYER TG Modulation of estrogen receptor alpha protein level and survival function by DBC-1. Mol Endocrinol 2007; 21: 1526-1536. doi:10.1210/me.2007-0064
4. SUNDARARAJAN R, CHEN G, MUKHERJEE C, WHITE E Caspase-dependent processing activates the proapoptotic activity of deleted in breast cancer-1 during tumor necrosis factor-alpha-mediated death signaling. Oncogene 2005; 24: 4908-4920. doi:10.1038/sj.onc.1208681
5. FU J, JIANG J, LI J, WANG S, SHI G et al. The deleted in breast cancer 1 (DBC-1): A novel AR coactivator that promotes AR DNA binding activity. J Biol Chem 2009: 284: 6832-6840. doi:10.1074/jbc.M808988200
6. GARAPATY S, XU CF, TROJER P, MAHAJAN MA, NEUBERT TA et al. Identification and characterization of a novel nuclear protein complex Involved In nuclear hormone receptor-mediated gene regulation. J Biol Chem 2009: 284: 7542-7552. doi:10.1074/jbc.M805872200
7. KIM JE, CHEN J, LOU Z p30 DBC is a potential regulator of tumorigenesis. Cell Cycle 2009; 8: 2932-2935.
8. LI Z, CHEN L, KABRA N, WANG C, FANG J et al. Inhibition of SUV39H1 methyltransferase activity by DBC1. J Biol Chem 2009: 284: 10361-10366. doi:10.1074/jbc.M900956200
9. RADVANYI L, SINGH-SANDHU D, GALLICHAN S, LOVITT C, PEDYCZAK A et al. The gene associated with trichorhinophalangeal syndrome in humans is overexpressed in breast cancer. Proc Natl Acad Sci U S A 2005; 102: 11005-11010. doi:10.1073/pnas.0500904102
10. RICHARDSON AL, WANG ZC, DE NICOLO A, LU X, BROWN M et al. X chromosomal abnormalities in basallike human breast cancer. Cancer Cell 2006; 9: 121-132. doi:10.1016/j.ccr.2006.01.013
11. CHA EJ, NOH SJ, KWON KS, KIM CY, PARK BH et al. Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma. Clin Cancer Res 2009; 15: 4453-4459. doi:10.1158/1078-0432.CCR-08-3329
12. TSENG RC, LEE CC, HSU HS, TZAO C, WANG YC Distinct HIC1-SIRT1-p53 loop deregulation in lung squamous carcinoma and adenocarcinoma patients. Neoplasia 2009; 11: 763-770.
13. MACARTNEY-COXSON DP, HOOD KA, SHI HJ, WARD T, WILES A et al. Metastatic susceptibility locus, an 8p hot-spot for tumour progression disrupted in colorectal liver metastases: 13 candidate genes examined at the DNA, mRNA and protein level. BMC Cancer 2008; 8: 187. doi:10.1186/1471-2407-8-187
14. REID JF, GARIBOLDI M, SOKOLOVA V, CAPOBIANCO P, LAMPIS A et al. Integrative approach for prioritizing cancer genes in sporadic colon cancer. Genes Chromosomes Cancer 2009; 48: 953-962. doi:10.1002/gcc.20697
15. JIN Y, XU XL, YANG MC, WEI F, AYI TC et al. Cell cycledependent colocalization of BARD1 and BRCA1 proteins in discrete nuclear domains. Proc Natl Acad Sci U S A 1997; 94: 12075-12080. doi:10.1073/pnas.94.22.12075
16. ANANTHARAMAN V, ARAVIND L Analysis of DBC1 and its homologs suggests a potential mechanism for regulation of sirtuin domain deacetylases by NAD metabolites. Cell Cycle 2008; 7: 1467-1472.
17. KIM JE, LOU Z, CHEN J Interactions between DBC1 and SIRT 1 are deregulated in breast cancer cells. Cell Cycle 2009; 8: 3784-3785.