Loss of Y chromosome in the malignant peripheral nerve sheet tumor of a patient with neurofibromatosis type 1

Journal of Korean Medical Science

Volumn 25, Issue 5, 2010, Pages 804-808

  Jeong, Seon Yong ^a   Park, Sang Jin ^b   Lee, Su Jin ^a   Park, Ho Jin ^a   Kim, Hyon J ^a  

^a Ajou University School of Medicine   (South Korea)

^b MG MED Inc   (South Korea)

Author keywords

CGH array; Chromosome loss; G banding; Nerve sheath neoplasms; Neurofibromatosis 1; Y chromosome

Indexed keywords

ADULT; ARTICLE; CASE REPORT; GENETICS; HUMAN; NERVE SHEATH TUMOR; NEUROFIBROMATOSIS; Y CHROMOSOME;

CHROMOSOMES, HUMAN, Y; HUMANS; NERVE SHEATH NEOPLASMS; NEUROFIBROMATOSIS 1; YOUNG ADULT;

EID: 77955290577     PISSN: 10118934     EISSN: 15986357     Source Type: Journal    
DOI: 10.3346/jkms.2010.25.5.804     Document Type: Article

References (20)

1. Savar A, Cestari DM. Neurofibromatosis type I: genetics and clinical manifestations. Semin Ophthalmol 2008; 23: 45-51.
2. Huson SM. Neurofibromatosis 1: a clinical and genetic overview. In: Huson, Hughes RAC (eds). The neurofibromatosis. Chapman and Hall Medical, London, 1994; 160-203.
3. Evans DG, Baser ME, McGaughran J, Sharif S, Howard E, Moran A. Malignant peripheral nerve sheath tumours in neurofibromatosis 1. J Med Genet 2002; 39: 311-4.
4. Brunetti-Pierri N, Grange DK, Ou Z, Peiffer DA, Peacock SK, Cooper ML, Eng PA, Lalani SR, Chinault AC, Gunderson KL, Craigen WJ, Cheung SW. Characterization of de novo microdeletions involving 17q11.2q12 identified through chromosomal comparative genomic hybridization. Clin Genet 2007; 72: 411-9.
5. Legius E, Marchuk DA, Collins FS, Glover TW. Somatic deletion of the neurofibromatosis type 1 gene in a neurofibrosarcoma supports a tumour suppressor gene hypothesis. Nat Genet 1993; 3: 122-6.
6. Jeong SY, Han JH, Park YY, Kim HJ. Identification of differentially expressed genes related to NF1-associated malignant transformation from a patient with neurofibromatosis type 1. Genes and Genomics 2008; 30: 407-18.
7. Koga T, Iwasaki H, Ishiguro M, Matsuzaki A, Kikuchi M. Frequent genomic imbalances in chromosomes 17, 19, and 22q in peripheral nerve sheath tumours detected by comparative genomic hybridization analysis. J Pathol 2002; 197: 98-107.
8. Yano S, Matsuyama H, Matsuda K, Matsumoto H, Yoshihiro S, Naito K. Accuracy of an array comparative genomic hybridization (CGH) technique in detecting DNA copy number aberrations: comparison with conventional CGH and loss of heterozygosity analysis in prostate cancer. Cancer Genet Cytogenet 2004; 150: 122-7.
9. Serra E, Puig S, Otero D, Gaona A, Kruyer H, Ars E, Estivill X, Lázaro C. Confirmation of a double-hit model for the NF1 gene in benign neurofibromas. Am J Hum Genet 1997; 61: 512-9.
10. Upadhyaya M, Kluwe L, Spurlock G, Monem B, Majounie E, Mantripragada K, Ruggieri M, Chuzhanova N, Evans DG, Ferner R, Thomas N, Guha A, Mautner V. Germline and somatic NF1 gene mutation spectrum in NF1-associated malignant peripheral nerve sheath tumors (MPNSTs). Hum Mutat 2008; 29: 74-82.
11. Carroll SL, Ratner N. How does the Schwann cell lineage form tumors in NF1? Glia 2008; 56: 1590-605.
12. Lothe RA, Karhu R, Mandahl N, Mertens F, Sauter G, Heim S, Borresen-Dale AL, Kallioneimi. Gain of 17q24-qter detected by comparative genomic hybridization in malignant tumors from patients with von Recklinghausen's neurofibromatosis. Cancer Res 1996; 56: 4778-81.
13. Schmidt H, Taubert H, Meye A, Würl P, Bache M, Bartel F, Holzhausen HJ, Hinze R. Gains in chromosomes 7, 8q, 15q and 17q are characteristic changes in malignant but not in benign peripheral nerve sheath tumors from patients with Recklinghausen's disease. Cancer Lett 2000; 155: 181-90.
14. Bartsch O, Vlcková Z, Erdogan F, Ullmann R, Novotná D, Spiegel M, Beyer V, Haaf T, Zechner U, Seemanová E. Two independent chromosomal rearrangements, a very small (550 kb) duplication of the 7q subtelomeric region and an atypical 17q11.2 (NF1) microdeletion, in a girl with neurofibromatosis. Cytogenet Genome Res 2007; 119: 158-64.
15. Wong AK, Fang B, Zhang L, Guo X, Lee S, Schreck R. Loss of the Y chromosome: an age-related or clonal phenomenon in acute myelogenous leukemia/myelodysplastic syndrome? Arch Pathol Lab Med 2008; 132: 1329-32.
16. Wallrapp C, Hahnel S, Boeck W, Soder A, Mincheva A, Lichter P, Leder G, Gansauge F, Sorio C, Scarpa A, Gress TM. Loss of the Y chromosome is a frequent chromosomal imbalance in pancreatic cancer and allows differentiation to chronic pancreatitis. Int J Cancer 2001; 91: 340-4.
17. Kujawski M, Jarmuz M, Rydzanicz M, Szukala K, Wierzbicka M, Grenman R, Golusinski W, Szyfter K. Frequent chromosome Y loss in primary, second primary and metastatic squamous cell carcinomas of the head and neck region. Cancer Lett 2004; 208: 95-101.
18. Wiktor A, Rybicki BA, Piao ZS, Shurafa M, Barthel B, Maeda K, Van Dyke DL. Clinical significance of Y chromosome loss in hematologic disease. Genes Chromosomes Cancer 2000; 27: 11-6.
19. Park SJ, Jeong SY, Kim HJ. Y chromosome loss and other genomic alterations in hepatocellular carcinoma cell lines analyzed by CGH and CGH array. Cancer Genet Cytogenet 2006; 166: 56-64.
20. Stevenson DA, Birch PH, Friedman JM, Viskochil DH, Balestrazzi P, Boni S, Buske A, Korf BR, Niimura M, Pivnick EK, Schorry EK, Short MP, Tenconi R, Tonsgard JH, Carey JC. Descriptive analysis of tibial pseudarthrosis in patients with neurofibromatosis 1. Am J Med Genet 1999; 84: 413-9.