Sepsis is a major determinant of outcome in critically ill HIV/AIDS patients

Critical Care

Volumn 14, Issue 4, 2010, Pages

  Japiassú, André M ^a   Amâncio, Rodrigo T ^a   Mesquita, Emerson C ^a   Medeiros, Denise M ^a   Bernal, Helena B ^b   Nunes, Estevão P ^b   Luz, Paula M ^b   Grinsztejn, Beatriz ^b   Bozza, Fernando A ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b Funda??o Oswaldo Cruz   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADULT; AIDS PATIENT; ARTICLE; CD4 LYMPHOCYTE COUNT; CRITICALLY ILL PATIENT; DISEASE SEVERITY; FEMALE; FOLLOW UP; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HOSPITAL ADMISSION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION RISK; INTENSIVE CARE UNIT; LENGTH OF STAY; LOWER RESPIRATORY TRACT INFECTION; MAJOR CLINICAL STUDY; MALE; MORTALITY; OPPORTUNISTIC INFECTION; PRIORITY JOURNAL; PROSPECTIVE STUDY; RESPIRATORY FAILURE; SEPSIS; SEPTIC SHOCK; SURVIVAL TIME; TREATMENT OUTCOME; AIDS RELATED COMPLEX; CHI SQUARE DISTRIBUTION; CRITICAL ILLNESS; MICROBIOLOGY; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROPORTIONAL HAZARDS MODEL; STATISTICS; SURVIVAL;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ADULT; AIDS-RELATED OPPORTUNISTIC INFECTIONS; CHI-SQUARE DISTRIBUTION; CRITICAL ILLNESS; FEMALE; HIV INFECTIONS; HOSPITAL MORTALITY; HUMANS; INTENSIVE CARE UNITS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PROPORTIONAL HAZARDS MODELS; PROSPECTIVE STUDIES; SEPSIS; SHOCK, SEPTIC; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 77955283530     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc9221     Document Type: Article

References (53)

1. UNAIDS/WHO AIDS Epidemic Update 2009. UNAIDS/WHO., http://data.unaids.org/pub/Report/2009/2009_epidemic_update_en.pdf
2. Afessa B, Green B. Clinical course, prognostic factors, and outcome prediction for HIV patients in the ICU: The PIP (Pulmonary Complications, ICU Support, and Prognostic Factors in Hospitalized Patients with HIV) Study. Chest 2000, 118:138-145. 10.1378/chest.118.1.138, 10893371.
3. Morris A, Creasman J, Turner J, Luce JM, Watcher RM, Huang L. Intensive care of human immunodeficiency virus-infected patients during the era of highly active antiretroviral therapy. Am J Respir Crit Care Med 2002, 166:262-267. 10.1164/rccm.2111025, 12153955.
4. Narasihman M, Posner AJ, DePalo VA, Mayo PH, Rosen MJ. Intensive care in patients with HIV infection in the era of highly active antiretroviral therapy. Chest 2004, 125:1800-1804. 10.1378/chest.125.5.1800, 15136393.
5. Khouli H, Afrasiabi A, Shibli M, Hajal R, Barrett CR, Homel P. Outcome of critically ill human immunodeficiency virus-infected patients in the era of highly active antiretroviral therapy. J Intensive Care Med 2005, 20:327-333. 10.1177/0885066605281087, 16280405.
6. Palacios R, Hidalgo A, Reina C, de la Torre MV, Márquez M, Santos J. Effect of antiretroviral therapy on admissions of HIV-infected patients to an intensive care unit. HIV Med 2006, 7:193-196. 10.1111/j.1468-1293.2006.00353.x, 16494634.
7. Powell K, Davis JL, Morris AM, Chi A, Bensley MR, Huang L. Survival for patients with HIV admitted to the ICU continues to improve in the current era of combination antiretroviral therapy. Chest 2009, 135:11-17. 10.1378/chest.08-0980, 2742310, 18719058.
8. Huang L, Quartin A, Jones D, Havlir DV. Intensive care of patients with HIV infection. N Engl J Med 2006, 355:173-181. 10.1056/NEJMra050836, 16837681.
9. Rosen MJ, Narasimhan M. Critical care of immunocompromised patients: human immunodeficiency virus. Crit Care Med 2006, 34:S245-S250. 10.1097/01.CCM.0000232491.15369.AB, 16917430.
10. Davaro RE, Thirumalai A. Life-threatening complications of HIV infection. J Intensive Care Med 2007, 22:73-81. 10.1177/0885066606297964, 17456727.
11. Grinsztejn B, Veloso VG, Friedman RK, Moreira RI, Luz PM, Campos DP, Pilotto JH, Cardoso SW, Keruly JC, Moore RD. Early mortality and cause of deaths in patients using HAART in Brazil and the United States. AIDS 2009, 23:2107-2114. 10.1097/QAD.0b013e32832ec494, 19770698.
12. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 2001, 29:1303-1310. 10.1097/00003246-200107000-00002, 11445675.
13. Martin GS, Mannino DM, Eaton S, Moss M. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003, 348:1546-1554. 10.1056/NEJMoa022139, 12700374.
14. Annane D, Aegerter P, Jars-Guincestre MC, Guidet B. Current epidemiology of septic shock. Am J Resp Crit Care Med 2003, 168:165-172. 10.1164/rccm.2201087, 12851245.
15. The EPISEPSIS Study Group EPISEPSIS: a reappraisal of the epidemiology and outcome of severe sepsis in French intensive care units. Intensive Care Med 2004, 30:580-588. 10.1007/s00134-003-2121-4, 14997295, The EPISEPSIS Study Group.
16. Ballester JCA, Ballester F, Sánchez AG, Quilis AA, Rubio EC, Otero CP. Epidemiology of sepsis in the valencian community (Spain), 1995-2004. Infect Control Hosp Epidemiol 2008, 29:630-634. 10.1086/589583, 18564905.
17. Blanco J, Muriel-Bombín A, Sagredo V, Taboada F, Gandía F, Tamayo L, Collado J, García-Labattut A, Carriedo D, Valledor M, De Frutos M, López MJ, Caballero A, Guerra J, Alvarez B, Mayo A, Villar J, . Grupo de Estudios y Análisis en Cuidados Intensivos Incidence, organ dysfunction and mortality in severe sepsis: a Spanish multicentre study. Crit Care 2008, 12:R158. 2646323, 19091069, Grupo de Estudios y Análisis en Cuidados Intensivos.
18. Khwannimit B, Bhurayanontachai R. The epidemiology of, and risk factors for, mortality from severe sepsis and septic shock in a tertiary-care university hospital setting. Epidemiol Infect 2009, 137:1333-1341. 10.1017/S0950268809002027, 19192320.
19. Beale R, Reinhart K, Brunkhorst FM, Dobb G, Levy M, Martin G, Martin C, Ramsey G, Silva E, Vallet B, Vincent JL, Janes JM, Sarwat S, Williams MD, . PROGRESS Advisory Board Promoting Global Research Excellence in Severe Sepsis (PROGRESS): lessons from an international sepsis registry. Infection 2009, 37:222-232. PROGRESS Advisory Board.
20. Mrus JM, Braun LA, Yi MS, Linde-Zwirble WT, Johnston JA. Impact of HIV/AIDS on care and outcomes of severe sepsis. Crit Care 2005, 9:R623-R630. 10.1186/cc3811, 1378113, 16280060.
21. Soares M, Terzi RGG, Piva JP. End-of-life care in Brazil. Intensive Care Med 2007, 33:1014-1017. 10.1007/s00134-007-0623-1, 17410343.
22. Centers for Disease Control and Prevention (CDC) Impact of the expanded AIDS surveillance case definition on AIDS case reporting--United States, first quarter, 1993. MMWR Morb Mortal Wkly Rep 1993, 42:308-311. Centers for Disease Control and Prevention (CDC).
23. Le Gall JR, Lemeshow S, Saulnier F. A new Simplified Acute Physiologic Score (SAPS II) based on an European/North American multicenter study. JAMA 1993, 270:2957-2963. 10.1001/jama.270.24.2957, 8254858.
24. Le Gall JR, Neumann A, Hemery F, Bleriot JP, Fulgencio JP, Garrigues B, Gouzes C, Lepage E, Moine P, Villers D. Mortality prediction using SAPS II: an update for French intensive care units. Crit Care 2005, 9:R645-R652. 10.1186/cc3821, 1414016, 16280063.
25. Vincent JL, Moreno R, Takala J, Willatts S, de Mendonça A, Bruining H, Reinhart CK, Suter PM, Thijs LG. The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. Intensive Care Med 1996, 22:707-710. 10.1007/BF01709751, 8844239.
26. Zubrod CG, Schneiderman M, Frei E. Appraisal of methods for the study of chemotherapy of cancer in man: comparative therapeutic trial of nitrogen mustard and triethylene thiophosphoramide. J Chron Dis 1960, 11:7-33.
27. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis: the ACCP/SCCM Consensus Conference Committee, American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992, 101:1644-1655. 10.1378/chest.101.6.1644, 1303622.
28. Horan TC, Andrus M, Dudeck MA. CDC/NHSN surveillance definition of health care-associated infection and criteria for specific types of infections in the acute care setting. Am J Infect Control 2008, 36:309-332. 10.1016/j.ajic.2008.03.002, 18538699.
29. R Project. , http://www.r-project.org
30. Pacheco AG, Tuboi SH, May SB, Moreira LFS, Ramadas L, Nunes EP, Merçon M, Faulhaber JC, Harrison LH, Schechter M. Temporal changes in causes of death among HIV-infected patients in the HAART era in Rio de Janeiro, Brazil. J Acquir Immune Defic Syndr 2009, 51:624-630. 10.1097/QAI.0b013e3181a4ecf5, 2748737, 19430304.
31. Casalino E, Wolff M, Ravaud P, Choquet C, Bruneel F, Regnier B. Impact of HAART advent on admission patterns and survival in HIV-infected patients admitted to an intensive care unit. AIDS 2004, 18:1429-1433. 10.1097/01.aids.0000131301.55204.a7, 15199319.
32. Angus DC, Wax RS. Epidemiology of sepsis: an update. Crit Care Med 2001, 29:S109-S116. 10.1097/00003246-200107001-00035, 11445744.
33. Petrosillo N, Pagani L, Ippolito G, . Gruppo HIV e Infezioni Ospedaliere Nosocomial infections in HIV-positive patients: an overview. Infection 2003, (Suppl 2):28-34. Gruppo HIV e Infezioni Ospedaliere.
34. Thyrault M, Gachot B, Chastang C, Souweine B, Timsit JF, Bédos JP, Regnier B, Wolff M. Septic shock in patients with the acquired immunodeficiency syndrome. Intensive Care Med 1997, 23:1018-1023. 10.1007/s001340050451, 9407236.
35. Rosenberg AL, Seneff MG, Atiyeh L, Wagner R, Bojanowski L, Zimmerman JE. The importance of bacterial sepsis in intensive care unit patients with acquired immunodeficiency syndrome: implications for future care in the age of increasing antiretroviral resistance. Crit Care Med 2001, 29:548-556. 10.1097/00003246-200103000-00013, 11373418.
36. Arthur G, Nduba VN, Kariuki SM, Kimari J, Bhatt SM, Gilks CF. Trends in bloodstream infections among human immunodeficiency virus-infected adults admitted to a hospital in Nairobi, Kenya, during the last decade. Clin Infect Dis 2001, 33:248-256. 10.1086/321820, 11418886.
37. Hung CC, Hsueh PR, Hsieh SM, Liu CJ, Chen MY, Luh KT. Bacteremia and fungemia in patients with advanced human immunodeficiency vírus (HIV) infection in Taiwan. J Formos Med Assoc 1998, 97:690-697.
38. Tumbarello M, Tacconelli E, Donati KG, Citton R, Leone F, Spanu T, Cauda R. HIV-associated bacteremia: how it has changed in the highly active antiretroviral therapy (HAART) era. J Acquir Immune Defic Syndr 2000, 23:145-151.
39. Vidal F, Mensa J, Martínez JA, Almela M, Marco F, Gatell JM, Richart C, Soriano E, Jiménez de Anta MT. Pseudomonas aeruginosa bacteremia in patients infected with human immunodeficiency virus type 1. Eur J Clin Microbiol Infect Dis 1999, 18:473-477. 10.1007/s100960050326, 10482023.
40. Grinsztejn B, Veloso VG, Pilotto JH, Campos DP, Keruly JC, Moore RD. Comparison of clinical response to initial highly active antiretroviral therapy in the patients in clinical care in the United States and Brazil. J Acquir Immune Defic Syndr 2007, 45:515-520. 10.1097/QAI.0b013e3180decb6a, 17558332.
41. Schmaltz CA, Santanna FM, Neves SC, Velasque LD, Lourenço MC, Morgado MG, Rolla VC, Lopes GS. Influence of HIV infection on mortality in a cohort of patients treated for tuberculosis in the context of wide access to HAART, in Rio de Janeiro, Brazil. J Acquir Immune Defic Syndr 2009, 52:623-628. 10.1097/QAI.0b013e3181b31e56, 19730270.
42. Pacheco AG, Durovni B, Cavalcante SC, Lauria LM, Moore RD, Moulton LH, Chaisson RE, Golub JE. AIDS-related tuberculosis in Rio de Janeiro, Brazil. PLoS One 2008, 3:e3132. 10.1371/journal.pone.0003132, 2518952, 18781195.
43. Waddell RD, Lishimpia K, von Reyn CF, Chintua C, Babooa KS, Kreiswirthb B, Talbotc EA, Karagas MR. Study Group: bacteremia due to Mycobacterium tuberculosis or M. bovis, Bacille Calmette-Guerin (BCG) among HIV positive children and adults in Zambia. AIDS 2001, 15:55-60. 10.1097/00002030-200101050-00009, 11192868.
44. Grinsztejn B, Fandinho FC, Veloso VG, João EC, Lourenço MC, Nogueira SA, Fonseca LS, Werneck-Barroso E. Mycobacteremia in patients with the acquired immunodeficiency syndrome. Arch Intern Med 1997, 157:2359-2363. 10.1001/archinte.157.20.2359, 9361577.
45. Croda J, Croda MG, Neves A, Santos SS. Benefit of antiretroviral therapy on survival of human immunodeficiency virus-infected patients admitted to an intensive care unit. Crit Care Med 2009, 37:1605-1611. 10.1097/CCM.0b013e31819da8c7, 19325488.
46. Vincent B, Timsit JF, Auburtin M, Schortgen F, Bouadma L, Wolff M, Regnier B. Characteristics and outcomes of HIV-infected patients in the ICU: impact of the highly active antiretroviral treatment era. Intensive Care Med 2004, 30:859-866. 10.1007/s00134-004-2158-z, 14767592.
47. Davis JL, Morris A, Kallet RH, Powell K, Chi AS, Bensley M, Luce JM, Huang L. Low tidal volume ventilation is associated with reduced mortality in HIV-infected patients with acute lung injury. Thorax 2008, 63:988-993. 10.1136/thx.2008.095786, 2677080, 18535118.
48. Silva E, Pedro Mde A, Sogayar AC, Mohovic T, Silva CL, Janiszewski M, Cal RG, de Sousa EF, Abe TP, de Andrade J, de Matos JD, Rezende E, Assunção M, Avezum A, Rocha PC, de Matos GF, Bento AM, Corrêa AD, Vieira PC, Knobel E, . Brazilian Sepsis Epidemiological Study Brazilian Sepsis Epidemiological Study (BASES study). Crit Care 2004, 8:R251-R260. 10.1186/cc2727, 206415, 1531222, Brazilian Sepsis Epidemiological Study.
49. Sales-Júnior JA, David CM, Hatum R, Souza PC, Japiassú A, Pinheiro CT, Friedman G, Silva OB, Dias MD, Koterba E, Dias FS, Piras C, Luiz RR. An epidemiological study of sepsis in intensive care units. Sepsis Brazil Study. Rev Bras Ter Intens 2006, 18:9-17.
50. Dellinger RP, Levy MM, Carlet JM, Bion J, Parker MM, Jaeschke R, Reinhart K, Angus DC, Brun-Buisson C, Beale R, Calandra T, Dhainaut JF, Gerlach H, Harvey M, Marini JJ, Marshall J, Ranieri M, Ramsay G, Sevransky J, Thompson BT, Townsend S, Vender JS, Zimmerman JL, Vincent JL, et al. International Surviving Sepsis Campaign Guidelines Committee; American Association of Critical-Care Nurses; American College of Chest Physicians; American College of Emergency Physicians; Canadian Critical Care Society; European Society of Clinical Microbiology and Infectious Diseases Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med 2008, 36:296-327. 10.1097/01.CCM.0000298158.12101.41, 18158437, International Surviving Sepsis Campaign Guidelines Committee; American Association of Critical-Care Nurses; American College of Chest Physicians; American College of Emergency Physicians; Canadian Critical Care Society; European Society of Clinical Microbiology and Infectious Diseases.
51. Becker JU, Theodosis C, Jacob ST, Wira CR, Groce NE. Surviving sepsis in low-income and middle-income countries: new directions for care and research. Lancet Infect Dis 2009, 9:577-582. 10.1016/S1473-3099(09)70135-5, 19695494.
52. Cheng AC, West TE, Limmathurotsakul D, Peacock SJ. Strategies to reduce mortality from bacterial sepsis in adults in developing countries. PLoS Med 2008, 5:e175. 10.1371/journal.pmed.0050175, 2517616, 18752342.
53. Bozza FA, Salluh JI. An urban perspective on sepsis in developing countries. Lancet Infect Dis 2010, 10:290-291. 10.1016/S1473-3099(10)70074-8, 20417408.