Implantable MEMS compressive stress sensors: Design, fabrication and calibration with application to the disc annulus

Journal of Biomechanics

Volumn 43, Issue 11, 2010, Pages 2244-2248

  Glos, David L ^a   Sauser, Frank E ^a,b   Papautsky, Ian ^b   Bylski Austrow, Donita I ^a  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b 705 Engineering Research Center   (United States)

Author keywords

Compressive stress; Intervertebral disc; Mechanobiology; Microsensors; Physiological loads; Pressure measurements; Sensor packaging; Spine biomechanics

Indexed keywords

INTERVERTEBRAL DISCS; MECHANO-BIOLOGY; PHYSIOLOGICAL LOADS; SENSOR PACKAGING; SPINE BIOMECHANICS;

BIOMECHANICS; CALIBRATION; COMPOSITE MICROMECHANICS; COMPRESSIVE STRESS; DESIGN; DIES; HYDRAULICS; HYDRODYNAMICS; HYDROSTATIC PRESSURE; IMPLANTS (SURGICAL); MEMS; MICROELECTROMECHANICAL DEVICES; MICROSENSORS; MUSCULOSKELETAL SYSTEM; PRESSURE MEASUREMENT; PRESSURE SENSORS; TENSILE STRESS; TISSUE ENGINEERING;

NANOSENSORS;

ANIMAL EXPERIMENT; ARTICLE; BIOMECHANICS; BIOSENSOR; CALIBRATION; COMPRESSION; CONTACT STRESS; ELECTRIC POTENTIAL; EQUIPMENT DESIGN; HYDROSTATIC PRESSURE; IMPLANTATION; IN VIVO STUDY; INTERVERTEBRAL DISK; MICROELECTROMECHANICAL SYSTEM; MICROTECHNOLOGY; NONHUMAN; NUCLEUS PULPOSUS; PRESSURE MEASUREMENT; PRIORITY JOURNAL;

ANIMALS; BIOSENSING TECHNIQUES; CALIBRATION; COMPRESSIVE STRENGTH; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; INTERVERTEBRAL DISK; MANOMETRY; MICRO-ELECTRICAL-MECHANICAL SYSTEMS; PROSTHESES AND IMPLANTS; STRESS, MECHANICAL; SWINE; UNITED STATES;

EID: 77955277475     PISSN: 00219290     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2010.04.006     Document Type: Article

References (29)

1. Abe E., Nickel T., Butterman G.R., Lewis J.L., Transfeldt E.E. Lumbar intradiscal pressure after posterolateral fusion and pedicle screw fixation. Tohodu Journal Experimental Medicine 1998, 186:243-253.
2. Alini M., Eisenstein S.M., Ito K., Little C., Kettler A.A., Masuda K., Melrose J., Ralphs J., Stokes I., Wilke H.J. Are animal models useful for studying human disc disorders/degeneration?. European Spine Journal 2008, 17:2-19.
3. Buttermann G.R., Beaubien B.P. In vitro disc pressure profiles below scoliosis fusion constructs. Spine 2008, 33:2134-2142.
4. Buttermann G.R., Beaubien B.P., Saeger L.C. Mature runt cow lumbar intradiscal pressures and motion segment biomechanics. The Spine Journal 2009, 9:105-114.
5. Bylski-Austrow D.I., Glos D.L., Sauser F.E., Papautsky I., Crawford A.H., Wall E.J. Bilateral intra-annular spinal compressive stresses in vivo. Research into Spinal Deformities 5. IOS Press 2006, 398-403. D. Uyttendaele, P.H. Dangerfield (Eds.).
6. Cripton P.A., Dumas G.A., Nolte L.-P. A minimally disruptive technique for measuring intervertebral disc pressure in vitro: application to the cervical spine. Journal of Biomechanics 2001, 34:545-549.
7. Cunningham B.W., Kotani Y., McNulty P.S., Cappuccino A., McAfee P.C. The effect of spinal destabilization and instrumentation on lumbar intradiscal pressure. An in vitro biomechanical analysis. Spine 1997, 22(22):2655-2663.
8. Dennison C.R., Wild P.M., Dvorak M.F., Wilson D.R., Cripton P.A. Validation of a novel minimally invasive intervertebral disc pressure sensor utilizing in-fiber Bragg gratings in a porcine model. An ex vivo study. Spine 2008, 33:E589-E594.
9. Edwards W.T., Ordway N.R., Zheng Y., McCullen G., Han Z., Yuan H.A. Peak stresses observed in the posterior lateral annulus. Spine 2001, 26:1753-1759.
10. Guering T., Unglaub F., Lorenz H., Omlor G., Wilke H.J., Kroeber M.W. Intradiscal pressure measurements in normal discs, compressed discs and compressed discs treated with axial posterior disc distraction: an experimental study on the rabbit lumbar spine model. European Spine Journal 2006, 15:597-604.
11. Hauerstock, D., Reindl, R., Steffen, T., 2001. Telemetric measurement of compressive loads in the sheep lumbar spine. In: Proceedings of the 47th Annual Orthopaedic Research Society. San Francisco, California.
12. Lanyon L.E. In vivo bone strain recorded from thoracic vertebrae of sheep. Journal of Biomechanics 1972, 5:277-281.
13. Ledet E.H., Sachs B.L., Brunski J.B., Gatto C.E., Donzelli P.S. Real-time in vivo loading in the lumbar spine: Part 1. interbody implant: load cell design and preliminary results. Spine 2000, 25:2595-2600.
14. Li C., Sauser F.E., Azizkhan R.G., Ahn C.H., Papautsky I. Polymer flip-chip bonding of pressure sensors on flexible Kapton film for neonatal catheters. Journal of Micromechanics and Microengineering 2005, 15:1729-1735.
15. McNally D.S., Adams M.A. Internal intervertebral disc mechanics as revealed by stress profilometry. Spine 1992, 17:66-73.
16. McNally D.S., Adams M.A., Goodship A.E. Development and validation of a new transducer for intradiscal pressure measurement. Journal of Biomedical Engineering 1992, 14:495-498.
17. Moore M., Fulop S., Tabib-Azar M., Hart D. Piezoresistive pressure sensors in the measurement of intervertebral disc hydrostatic pressure. The Spine Journal 2009, 9:1030-1034.
18. Nachemson A.L. Disc pressure measurements. Spine 1981, 6:93-97.
19. Nachemson A., Elfstrom G. Intravital dynamic pressure measurements in lumbar discs. A study of common movements, maneuvers, and exercises. Scandinavian Journal of Rehabilitation Medicine 1970, Supplement No. 1:1-40.
20. Nachemson A., Morris J.M. In vivo measurements of intradiscal pressure. Journal of Bone and Joint Surgery 1964, 46-A:1077-1092.
21. Nesson, S.C., Yu, M., Hsieh, A.H., 2008. Transient pressure measurements in rat intervertebral discs during stress relaxation. In: Proceedings of the 54th Orthopaedic Research Society, San Francisco, California.
22. Polga D.J., Beaubian B.P., Kallemeier P.M., Schellhas K.P., Lew W.D., Butterman G.R., Wood K.B. Measurement of in vivo intradiscal pressure in healthy thoracic intervertebral discs. Spine 2004, 29:1320-1324.
23. Sato K., Kikuchi S., Yonezawa T. In vivo intradiscal pressure measurement in healthy individuals and in patients with ongoing back problems. Spine 1999, 24:2468-2474.
24. Silicon Microstructures Incorporated. SM5112 Harsh Environment Absolute Silicon Pressure Die datasheet. Available at 〈. http://www.si-micro.com/http:/www.si-micro.com/fileadmin/pdf/Datasheets/datasheet_SM5112.pdf.
25. Schultz A., Andersson G., Ortengren R., Haderspeck K., Nachemson A. Loads on the lumbar spine: validation of a biomechanical analysis by measurements of intradiscal pressures and myoelectric signals. Journal of Bone and Joint Surgery and horbar 1982, 64-A:713-720.
26. Szivek J.A., Roberto R.F., Slack J.M., Majeed B.S. An implantable strain measurement system designed to detect spine fusion. Preliminary results from a biomechanical in vivo study. Spine 2002, 27:487-497.
27. Szivek J.A., Roberto R.F., Margolis D.S. In vivo strain measurements from hardware and lamina during spine fusion. Journal of Biomedical Materials Research Part B, Applied Biomaterials 2005, 75:243-250.
28. Weinhoffer S.L., Guyer R.D., Herbert M., Griffith S.L. Intradiscal pressure measurements above an instrumented fusion. A cadaveric study. Spine 1995, 20:526-531.
29. Wilke H.J., Neef P., Caimi M., Hoogland T., Claes L.E. New in vivo measurements of pressures in the intervertebral disc in daily life. Spine 1999, 24:755-762.