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Volumn 237, Issue 2, 2009, Pages 154-167

Embryotoxic potential of N-methyl-pyrrolidone (NMP) and three of its metabolites using the rat whole embryo culture system

Author keywords

2 hydroxy N methylsuccinimide (2 HMSI); 5 hydroxy N methyl pyrrolidone (5 HNMP); balb c 3T3 cytotoxicity test; In vitro; N methyl 2 pyrrolidone (NMP); N methylsuccinimide (MSI); Whole embryo culture

Indexed keywords

1 METHYL 2 PYRROLIDINONE; 2 HYDROXY N METHYLSUCCINIMIDE; 5 HYDROXY N METHYLPYRROLIDONE; DRUG METABOLITE; N METHYLSUCCINIMIDE; UNCLASSIFIED DRUG;

EID: 67349127926     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.02.024     Document Type: Article
Times cited : (31)

References (79)
  • 1
    • 4444262009 scopus 로고    scopus 로고
    • Evaluation of exposure biomarkers from percutaneous absorption of N-methyl-2-pyrrolidone
    • Akesson B., Carnerup M.A., and Jonsson B.A. Evaluation of exposure biomarkers from percutaneous absorption of N-methyl-2-pyrrolidone. Scand. J. Work Environ. Health 30 4 (2004) 306-312
    • (2004) Scand. J. Work Environ. Health , vol.30 , Issue.4 , pp. 306-312
    • Akesson, B.1    Carnerup, M.A.2    Jonsson, B.A.3
  • 2
    • 0342275194 scopus 로고    scopus 로고
    • Major metabolic pathway for N-methyl-2-pyrrolidone in humans
    • Akesson B., and Jonsson B.A. Major metabolic pathway for N-methyl-2-pyrrolidone in humans. Drug Metab. Dispos. 25 2 (1997) 267-269
    • (1997) Drug Metab. Dispos. , vol.25 , Issue.2 , pp. 267-269
    • Akesson, B.1    Jonsson, B.A.2
  • 3
    • 0343810498 scopus 로고    scopus 로고
    • Biological monitoring of N-methyl-2-pyrrolidone using 5-hydroxy-N-methyl-2-pyrrolidone in plasma and urine as the biomarker
    • Akesson B., and Jonsson B.A. Biological monitoring of N-methyl-2-pyrrolidone using 5-hydroxy-N-methyl-2-pyrrolidone in plasma and urine as the biomarker. Scand. J. Work Environ. Health 26 3 (2000) 213-218
    • (2000) Scand. J. Work Environ. Health , vol.26 , Issue.3 , pp. 213-218
    • Akesson, B.1    Jonsson, B.A.2
  • 4
    • 0030964444 scopus 로고    scopus 로고
    • Experimental exposure of male volunteers to N-methyl-2-pyrrolidone (NMP): acute effects and pharmacokinetics of NMP in plasma and urine
    • Akesson B., and Paulsson K. Experimental exposure of male volunteers to N-methyl-2-pyrrolidone (NMP): acute effects and pharmacokinetics of NMP in plasma and urine. Occup. Environ. Med. 54 4 (1997) 236-240
    • (1997) Occup. Environ. Med. , vol.54 , Issue.4 , pp. 236-240
    • Akesson, B.1    Paulsson, K.2
  • 5
    • 0037025560 scopus 로고    scopus 로고
    • Dermal exposure to aqueous solutions of N-methyl pyrrolidone
    • Akrill P., Cocker J., and Dixon S. Dermal exposure to aqueous solutions of N-methyl pyrrolidone. Toxicol. Lett. 134 1-3 (2002) 265-269
    • (2002) Toxicol. Lett. , vol.134 , Issue.1-3 , pp. 265-269
    • Akrill, P.1    Cocker, J.2    Dixon, S.3
  • 6
    • 67349282599 scopus 로고    scopus 로고
    • American Conference of Governmental Industrial Hygienists (2008). TLVs® and BEIs®: Based on the Documentation of the Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices, ACGIH, Cincinnati.
    • American Conference of Governmental Industrial Hygienists (2008). TLVs® and BEIs®: Based on the Documentation of the Threshold Limit Values for Chemical Substances and Physical Agents and Biological Exposure Indices, ACGIH, Cincinnati.
  • 7
    • 0030748961 scopus 로고    scopus 로고
    • Stereoselective dysmorphogenicity of the enantiomers of the valproic acid analogue 2-N-propyl-4-pentynoic acid (4-yn-VPA): cross-species evaluation in whole embryo culture
    • Andrews J.E., Ebron-McCoy M.T., Bojic U., Nau H., and Kavlock R.J. Stereoselective dysmorphogenicity of the enantiomers of the valproic acid analogue 2-N-propyl-4-pentynoic acid (4-yn-VPA): cross-species evaluation in whole embryo culture. Teratology 55 5 (1997) 314-318
    • (1997) Teratology , vol.55 , Issue.5 , pp. 314-318
    • Andrews, J.E.1    Ebron-McCoy, M.T.2    Bojic, U.3    Nau, H.4    Kavlock, R.J.5
  • 8
    • 27844611972 scopus 로고    scopus 로고
    • Dermal absorption and urinary elimination of N-methyl-2-pyrrolidone
    • Bader M., Keener S.A., and Wrbitzky R. Dermal absorption and urinary elimination of N-methyl-2-pyrrolidone. Int. Arch. Occup. Environ. Health 78 8 (2005) 673-676
    • (2005) Int. Arch. Occup. Environ. Health , vol.78 , Issue.8 , pp. 673-676
    • Bader, M.1    Keener, S.A.2    Wrbitzky, R.3
  • 9
    • 38349116598 scopus 로고    scopus 로고
    • Human volunteer study on the inhalational and dermal absorption of N-methyl-2-pyrrolidone (NMP) from the vapour phase
    • Bader M., Wrbitzky R., Blaszkewicz M., Schaper M., and van Thriel C. Human volunteer study on the inhalational and dermal absorption of N-methyl-2-pyrrolidone (NMP) from the vapour phase. Arch. Toxicol. 82 1 (2008) 13-20
    • (2008) Arch. Toxicol. , vol.82 , Issue.1 , pp. 13-20
    • Bader, M.1    Wrbitzky, R.2    Blaszkewicz, M.3    Schaper, M.4    van Thriel, C.5
  • 10
    • 34247854902 scopus 로고    scopus 로고
    • Human experimental exposure study on the uptake and urinary elimination of N-methyl-2-pyrrolidone (NMP) during simulated workplace conditions
    • Bader M., Wrbitzky R., Blaszkewicz M., and van Thriel C. Human experimental exposure study on the uptake and urinary elimination of N-methyl-2-pyrrolidone (NMP) during simulated workplace conditions. Arch. Toxicol. 81 5 (2007) 335-346
    • (2007) Arch. Toxicol. , vol.81 , Issue.5 , pp. 335-346
    • Bader, M.1    Wrbitzky, R.2    Blaszkewicz, M.3    van Thriel, C.4
  • 11
    • 1542563259 scopus 로고    scopus 로고
    • The use of scientifically-validated in vitro tests for embryotoxicity
    • Balls M. The use of scientifically-validated in vitro tests for embryotoxicity. Atla 30 (2002) 265-273
    • (2002) Atla , vol.30 , pp. 265-273
    • Balls, M.1
  • 14
    • 0023019633 scopus 로고
    • Teratogenic potential of antimycotic drugs evaluated in the whole embryo culture system
    • Bechter R., Schmid B.P., and Mayer F.K. Teratogenic potential of antimycotic drugs evaluated in the whole embryo culture system. Fd. Chem. Toxic 24 6-7 (1986) 641-642
    • (1986) Fd. Chem. Toxic , vol.24 , Issue.6-7 , pp. 641-642
    • Bechter, R.1    Schmid, B.P.2    Mayer, F.K.3
  • 15
    • 0036097575 scopus 로고    scopus 로고
    • Selection of test chemicals for the ECVAM international validation study on in vitro embryotoxicity tests. European Centre for the Validation of Alternative Methods
    • Brown N.A. Selection of test chemicals for the ECVAM international validation study on in vitro embryotoxicity tests. European Centre for the Validation of Alternative Methods. Altern. Lab. Anim. 30 2 (2002) 177-198
    • (2002) Altern. Lab. Anim. , vol.30 , Issue.2 , pp. 177-198
    • Brown, N.A.1
  • 16
    • 0019806298 scopus 로고
    • Quantitation of rat embryonic development in vitro: A morphological scoring system
    • Brown, N.A., Fabro, S., 1981. Quantitation of rat embryonic development in vitro: a morphological scoring system. Teratology 24, 65-78.
    • (1981) Teratology , vol.24 , pp. 65-78
    • Brown, N.A.1    Fabro, S.2
  • 17
    • 0029584582 scopus 로고
    • In vitro assessment of the effect of methanol and the metabolite, formic acid, on embryonic development of the rat
    • Brown-Woodman P., Huq F., Hayes L., Herlihy C., Picker K., and Webster W.S. In vitro assessment of the effect of methanol and the metabolite, formic acid, on embryonic development of the rat. Teratology 52 (1995) 233-243
    • (1995) Teratology , vol.52 , pp. 233-243
    • Brown-Woodman, P.1    Huq, F.2    Hayes, L.3    Herlihy, C.4    Picker, K.5    Webster, W.S.6
  • 18
    • 21244480825 scopus 로고    scopus 로고
    • Concentrations of N-methyl-2-pyrrolidone (NMP) and its metabolites in plasma and urine following oral administration of NMP to rats
    • Carnerup M.A., Saillenfait A.M., and Jonsson B.A. Concentrations of N-methyl-2-pyrrolidone (NMP) and its metabolites in plasma and urine following oral administration of NMP to rats. Food. Chem. Toxicol. 43 9 (2005) 1441-1447
    • (2005) Food. Chem. Toxicol. , vol.43 , Issue.9 , pp. 1441-1447
    • Carnerup, M.A.1    Saillenfait, A.M.2    Jonsson, B.A.3
  • 19
    • 32644433187 scopus 로고    scopus 로고
    • Levels of N-methyl-2-pyrrolidone (NMP) and its metabolites in plasma and urine from volunteers after experimental exposure to NMP in dry and humid air
    • Carnerup M.A., Spanne M., and Jonsson B.A. Levels of N-methyl-2-pyrrolidone (NMP) and its metabolites in plasma and urine from volunteers after experimental exposure to NMP in dry and humid air. Toxicol. Lett. 162 2-3 (2006) 139-145
    • (2006) Toxicol. Lett. , vol.162 , Issue.2-3 , pp. 139-145
    • Carnerup, M.A.1    Spanne, M.2    Jonsson, B.A.3
  • 20
    • 36048974254 scopus 로고    scopus 로고
    • Struggles for equivalence: in vitro developmental toxicity model evolution in pharmaceuticals in 2006
    • Chapin R., Stedman D., Paquette J., Streck R., Kumpf S., and Deng S. Struggles for equivalence: in vitro developmental toxicity model evolution in pharmaceuticals in 2006. Toxicol In Vitro 21 8 (2006) 1545-1551
    • (2006) Toxicol In Vitro , vol.21 , Issue.8 , pp. 1545-1551
    • Chapin, R.1    Stedman, D.2    Paquette, J.3    Streck, R.4    Kumpf, S.5    Deng, S.6
  • 21
    • 0028071482 scopus 로고
    • Benzene and benzene metabolites as embryotoxic agents: effects on cultured rat embryos
    • Chapman D.E., Namkung M.J., and Juchau M.R. Benzene and benzene metabolites as embryotoxic agents: effects on cultured rat embryos. Toxicol. Appl. Pharmacol. 128 1 (1994) 129-137
    • (1994) Toxicol. Appl. Pharmacol. , vol.128 , Issue.1 , pp. 129-137
    • Chapman, D.E.1    Namkung, M.J.2    Juchau, M.R.3
  • 22
    • 0001200879 scopus 로고
    • The role of prevalidation in the development, validation and acceptance of alternative methods
    • Curren R.D., Southee J.A., Spielmann H., Liebsch M., Fentem J.H., and Balls M. The role of prevalidation in the development, validation and acceptance of alternative methods. Atla 23 (1995) 211-217
    • (1995) Atla , vol.23 , pp. 211-217
    • Curren, R.D.1    Southee, J.A.2    Spielmann, H.3    Liebsch, M.4    Fentem, J.H.5    Balls, M.6
  • 23
    • 0019207009 scopus 로고
    • In-vitro development of the rat parietal yolk sac
    • Ellington S.K.L., and New D.A.T. In-vitro development of the rat parietal yolk sac. J. Reprod. Fertil. 60 2 (1980) 377-382
    • (1980) J. Reprod. Fertil. , vol.60 , Issue.2 , pp. 377-382
    • Ellington, S.K.L.1    New, D.A.T.2
  • 24
    • 67349182005 scopus 로고    scopus 로고
    • European Commission, Recommendation from the Scientific Committee on Occupational Exposure Limits for N-Methyl-2-Pyrrolidone, 04.09
    • European Commission, Recommendation from the Scientific Committee on Occupational Exposure Limits for N-Methyl-2-Pyrrolidone. http://ec.europa.eu/employment_social/health_safety/docs/sum_119.pdf, 04.09.2007.
    • (2007)
  • 25
    • 67349257051 scopus 로고    scopus 로고
    • Improvement in standardization of the whole-embryo-culture (WEC): importance of a more precise staging
    • Flick B., and Klug S. Improvement in standardization of the whole-embryo-culture (WEC): importance of a more precise staging. Arch. Pharm. 361 Suppl. 4 (2000) R 168
    • (2000) Arch. Pharm. , vol.361 , Issue.SUPPL. 4
    • Flick, B.1    Klug, S.2
  • 26
    • 33745106680 scopus 로고    scopus 로고
    • Whole embryo culture: an important tool in developmental toxicology today
    • Flick B., and Klug S. Whole embryo culture: an important tool in developmental toxicology today. Curr. Pharm. Des. 12 12 (2006) 1467-1488
    • (2006) Curr. Pharm. Des. , vol.12 , Issue.12 , pp. 1467-1488
    • Flick, B.1    Klug, S.2
  • 27
    • 0642278951 scopus 로고    scopus 로고
    • International conference on harmonisation; final recommendations on the revision of the permitted daily exposures for two solvents, N-methylpyrrolidone and tetrahydrofuran, according to the maintenance procedures for the guidance Q3C impurities: residual solvents; availability
    • Food and Drug Administration (FDA)
    • Food and Drug Administration (FDA). International conference on harmonisation; final recommendations on the revision of the permitted daily exposures for two solvents, N-methylpyrrolidone and tetrahydrofuran, according to the maintenance procedures for the guidance Q3C impurities: residual solvents; availability. Fed. Reg. 68 219 (2003) 64352-64353
    • (2003) Fed. Reg. , vol.68 , Issue.219 , pp. 64352-64353
  • 28
    • 0019731686 scopus 로고
    • The role of visceral yolk sac in mediating protein utilization by rat embryos cultured in vitro
    • Freeman S.J., Beck F., and Lloyd J.B. The role of visceral yolk sac in mediating protein utilization by rat embryos cultured in vitro. J. Embryol. Exp. Morphol. 66 (1981) 223-234
    • (1981) J. Embryol. Exp. Morphol. , vol.66 , pp. 223-234
    • Freeman, S.J.1    Beck, F.2    Lloyd, J.B.3
  • 29
    • 0020974156 scopus 로고
    • Inhibition of proteolysis in rat yolk sac as a cause of teratogenesis. Effects of leupeptin in vitro and in vivo
    • Freeman S.J., and Lloyd J.B. Inhibition of proteolysis in rat yolk sac as a cause of teratogenesis. Effects of leupeptin in vitro and in vivo. J. Embryol. Exp. Morphol. 78 (1983) 183-193
    • (1983) J. Embryol. Exp. Morphol. , vol.78 , pp. 183-193
    • Freeman, S.J.1    Lloyd, J.B.2
  • 31
    • 8744223170 scopus 로고    scopus 로고
    • Validation of the embryonic stem cell test in the international ECVAM validation study on three in vitro embryotoxicity tests
    • Genschow E., Spielmann H., Scholz G., Pohl I., Seiler A., Clemann N., Bremer S., and Becker K. Validation of the embryonic stem cell test in the international ECVAM validation study on three in vitro embryotoxicity tests. Altern. Lab. Anim. 32 3 (2004) 209-244
    • (2004) Altern. Lab. Anim. , vol.32 , Issue.3 , pp. 209-244
    • Genschow, E.1    Spielmann, H.2    Scholz, G.3    Pohl, I.4    Seiler, A.5    Clemann, N.6    Bremer, S.7    Becker, K.8
  • 32
    • 0036098620 scopus 로고    scopus 로고
    • The ECVAM international validation study on in vitro embryotoxicity tests: results of the definitive phase and evaluation of prediction models. European Centre for the Validation of Alternative Methods
    • Genschow E., Spielmann H., Scholz G., Seiler A., Brown N., Piersma A., Brady M., Clemann N., Huuskonen H., Paillard F., Bremer S., and Becker K. The ECVAM international validation study on in vitro embryotoxicity tests: results of the definitive phase and evaluation of prediction models. European Centre for the Validation of Alternative Methods. Altern. Lab. Anim. 30 2 (2002) 151-176
    • (2002) Altern. Lab. Anim. , vol.30 , Issue.2 , pp. 151-176
    • Genschow, E.1    Spielmann, H.2    Scholz, G.3    Seiler, A.4    Brown, N.5    Piersma, A.6    Brady, M.7    Clemann, N.8    Huuskonen, H.9    Paillard, F.10    Bremer, S.11    Becker, K.12
  • 33
    • 0029074101 scopus 로고
    • Developmental toxicity of inhaled N-methylpyrrolidone in the rat
    • Hass U., Jakobsen B.M., and Lund S.P. Developmental toxicity of inhaled N-methylpyrrolidone in the rat. Pharmacol. Toxicol. 76 6 (1995) 406-409
    • (1995) Pharmacol. Toxicol. , vol.76 , Issue.6 , pp. 406-409
    • Hass, U.1    Jakobsen, B.M.2    Lund, S.P.3
  • 34
    • 0028244743 scopus 로고
    • Effects of prenatal exposure to N-methylpyrrolidone on postnatal development and behavior in rats
    • Hass U., Lund S.P., and Elsner J. Effects of prenatal exposure to N-methylpyrrolidone on postnatal development and behavior in rats. Neurotoxicol. Teratology 16 3 (1994) 241-249
    • (1994) Neurotoxicol. Teratology , vol.16 , Issue.3 , pp. 241-249
    • Hass, U.1    Lund, S.P.2    Elsner, J.3
  • 35
    • 0025827917 scopus 로고
    • Studies on the prenatal toxicity of N,N-dimethylformamide in mice, rats and rabbits
    • Hellwig J., Merkle J., Klimisch H.J., and Jackh R. Studies on the prenatal toxicity of N,N-dimethylformamide in mice, rats and rabbits. Food Chem. Toxicol. 29 3 (1991) 193-201
    • (1991) Food Chem. Toxicol. , vol.29 , Issue.3 , pp. 193-201
    • Hellwig, J.1    Merkle, J.2    Klimisch, H.J.3    Jackh, R.4
  • 36
    • 17444449052 scopus 로고    scopus 로고
    • Human experimental exposure to N-methyl-2-pyrrolidone (NMP): toxicokinetics of NMP, 5-hydroxy-N-methyl-2-pyrrolidone, N-methylsuccinimide and 2-hydroxy-N-methylsuccinimide (2-HMSI), and biological monitoring using 2-HMSI as a biomarker
    • Jonsson B.A., and Akesson B. Human experimental exposure to N-methyl-2-pyrrolidone (NMP): toxicokinetics of NMP, 5-hydroxy-N-methyl-2-pyrrolidone, N-methylsuccinimide and 2-hydroxy-N-methylsuccinimide (2-HMSI), and biological monitoring using 2-HMSI as a biomarker. Int. Arch. Occup. Environ. Health 76 4 (2003) 267-274
    • (2003) Int. Arch. Occup. Environ. Health , vol.76 , Issue.4 , pp. 267-274
    • Jonsson, B.A.1    Akesson, B.2
  • 38
    • 67349264761 scopus 로고    scopus 로고
    • Kiefer, M. National Institute for Occupational Safety and Health (NIOSH) Health Hazard Evaluation (HHE) Report on N-Methylpyrrolidone (NMP)- HETA-93-0844-2411. Rosebud Company, Atlanta, Georgia, USA. 1-3-1994. Available: http://www.cdc.gov/niosh/hhe/reports/pdfs/1993-0844-2411.pdf.
    • Kiefer, M. National Institute for Occupational Safety and Health (NIOSH) Health Hazard Evaluation (HHE) Report on N-Methylpyrrolidone (NMP)- HETA-93-0844-2411. Rosebud Company, Atlanta, Georgia, USA. 1-3-1994. Available: http://www.cdc.gov/niosh/hhe/reports/pdfs/1993-0844-2411.pdf.
  • 39
    • 0026386801 scopus 로고
    • Whole embryo culture: interpretation of abnormal development in vitro
    • Klug S. Whole embryo culture: interpretation of abnormal development in vitro. Reprod. Toxicol 5 3 (1991) 237-244
    • (1991) Reprod. Toxicol , vol.5 , Issue.3 , pp. 237-244
    • Klug, S.1
  • 40
    • 0022411174 scopus 로고
    • Modification and standardization of the culture of early postimplantation embryos for toxicological studies
    • Klug S., Lewandowski C., and Neubert D. Modification and standardization of the culture of early postimplantation embryos for toxicological studies. Arch. Toxicol. 58 (1985) 84-88
    • (1985) Arch. Toxicol. , vol.58 , pp. 84-88
    • Klug, S.1    Lewandowski, C.2    Neubert, D.3
  • 41
    • 0032055059 scopus 로고    scopus 로고
    • Potency of monomethyl-, dimethylformamide and some of their metabolites to induce abnormal development in a limb Bud organ culture
    • Klug S., Merker H.J., and Jäckh R. Potency of monomethyl-, dimethylformamide and some of their metabolites to induce abnormal development in a limb Bud organ culture. Toxicol. In Vitro 12 2 (1998) 123-132
    • (1998) Toxicol. In Vitro , vol.12 , Issue.2 , pp. 123-132
    • Klug, S.1    Merker, H.J.2    Jäckh, R.3
  • 42
    • 0034767890 scopus 로고    scopus 로고
    • Effects of ethylene glycol and metabolites on in vitro development of rat embryos during organogenesis
    • Klug S., Merker H.J., and Jackh R. Effects of ethylene glycol and metabolites on in vitro development of rat embryos during organogenesis. Toxicol. In Vitro 15 6 (2001) 635-642
    • (2001) Toxicol. In Vitro , vol.15 , Issue.6 , pp. 635-642
    • Klug, S.1    Merker, H.J.2    Jackh, R.3
  • 43
    • 0028175981 scopus 로고
    • Toxicity of beta-blockers in a rat embryo culture: concentration-response relationships and tissue concentration
    • Klug S., Thiel R., Schwabe R., Merker H.J., and Neubert D. Toxicity of beta-blockers in a rat embryo culture: concentration-response relationships and tissue concentration. Arch. Toxicol. 68 (1994) 375-384
    • (1994) Arch. Toxicol. , vol.68 , pp. 375-384
    • Klug, S.1    Thiel, R.2    Schwabe, R.3    Merker, H.J.4    Neubert, D.5
  • 44
    • 77957180794 scopus 로고
    • Toxicity of N-methyl-2-pyrrolidone (NMP): teratogenic, subchronic, and two-year inhalation studies
    • Lee K.P., Chromey N.C., Culik R., Barnes J.R., and Schneider P.W. Toxicity of N-methyl-2-pyrrolidone (NMP): teratogenic, subchronic, and two-year inhalation studies. Fundam. Appl. Toxicol. 9 2 (1987) 222-235
    • (1987) Fundam. Appl. Toxicol. , vol.9 , Issue.2 , pp. 222-235
    • Lee, K.P.1    Chromey, N.C.2    Culik, R.3    Barnes, J.R.4    Schneider, P.W.5
  • 46
    • 0026560352 scopus 로고
    • Percutaneous absorption of co-administered N-methyl-2-[14C]pyrrolidinone and 2-[14C]pyrrolidinone in the rat
    • Midgley I., Hood A.J., Chasseaud L.F., Brindley C.J., Baughman S., and Allan G. Percutaneous absorption of co-administered N-methyl-2-[14C]pyrrolidinone and 2-[14C]pyrrolidinone in the rat. Food. Chem. Toxicol. 30 1 (1992) 57-64
    • (1992) Food. Chem. Toxicol. , vol.30 , Issue.1 , pp. 57-64
    • Midgley, I.1    Hood, A.J.2    Chasseaud, L.F.3    Brindley, C.J.4    Baughman, S.5    Allan, G.6
  • 47
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 65 1-2 (1983) 55-63
    • (1983) J. Immunol. Methods , vol.65 , Issue.1-2 , pp. 55-63
    • Mosmann, T.1
  • 48
    • 67349218034 scopus 로고    scopus 로고
    • National Institute of Health, Household Product Database: N-Methylpyrrolidone. U.S.Department of Health and Human Services. 23-4-2008. Available: http://householdproducts.nlm.nih.gov/cgi-bin/household/brands?tbl=chem &id=211.
    • National Institute of Health, Household Product Database: N-Methylpyrrolidone. U.S.Department of Health and Human Services. 23-4-2008. Available: http://householdproducts.nlm.nih.gov/cgi-bin/household/brands?tbl=chem &id=211.
  • 51
    • 67349094188 scopus 로고    scopus 로고
    • OECD, 2001. Guideline for the testing of chemicals - Test No. 414: Prenatal Developmental Toxicity Study. OECD, Paris, France. 13pp.
    • OECD, 2001. Guideline for the testing of chemicals - Test No. 414: Prenatal Developmental Toxicity Study. OECD, Paris, France. 13pp.
  • 52
    • 0026513235 scopus 로고
    • In vitro embryotoxicity of a series of para-substituted phenols: structure, activity, and correlation with in vivo data
    • Oglesby L.A., Ebron-McCoy M.T., Logsdon T.R., Copeland F., Beyer P.E., and Kavlock R.J. In vitro embryotoxicity of a series of para-substituted phenols: structure, activity, and correlation with in vivo data. Teratology 45 1 (1992) 11-33
    • (1992) Teratology , vol.45 , Issue.1 , pp. 11-33
    • Oglesby, L.A.1    Ebron-McCoy, M.T.2    Logsdon, T.R.3    Copeland, F.4    Beyer, P.E.5    Kavlock, R.J.6
  • 54
    • 0036892716 scopus 로고    scopus 로고
    • Toxicokinetics and metabolism of N-[14C]methylpyrrolidone in male Sprague-Dawley rats. A saturable NMP elimination process
    • Payan J.P., Beydon D., Fabry J.P., Boudry I., Cossec B., and Ferrari E. Toxicokinetics and metabolism of N-[14C]methylpyrrolidone in male Sprague-Dawley rats. A saturable NMP elimination process. Drug Metab. Dispos. 30 12 (2002) 1418-1424
    • (2002) Drug Metab. Dispos. , vol.30 , Issue.12 , pp. 1418-1424
    • Payan, J.P.1    Beydon, D.2    Fabry, J.P.3    Boudry, I.4    Cossec, B.5    Ferrari, E.6
  • 55
    • 0037403454 scopus 로고    scopus 로고
    • Toxicokinetics and metabolism of N-[(14)C]N-methyl-2-pyrrolidone in male Sprague-Dawley rats: in vivo and in vitro percutaneous absorption
    • Payan J.P., Boudry I., Beydon D., Fabry J.P., Grandclaude M.C., Ferrari E., and Andre J.C. Toxicokinetics and metabolism of N-[(14)C]N-methyl-2-pyrrolidone in male Sprague-Dawley rats: in vivo and in vitro percutaneous absorption. Drug Metab. Dispos. 31 5 (2003) 659-669
    • (2003) Drug Metab. Dispos. , vol.31 , Issue.5 , pp. 659-669
    • Payan, J.P.1    Boudry, I.2    Beydon, D.3    Fabry, J.P.4    Grandclaude, M.C.5    Ferrari, E.6    Andre, J.C.7
  • 56
    • 1842666624 scopus 로고    scopus 로고
    • Validation of alternative methods for developmental toxicity testing
    • Piersma A.H. Validation of alternative methods for developmental toxicity testing. Toxicol. Lett. 149 1-3 (2004) 147-153
    • (2004) Toxicol. Lett. , vol.149 , Issue.1-3 , pp. 147-153
    • Piersma, A.H.1
  • 57
    • 67349245059 scopus 로고    scopus 로고
    • Piersma, A.H. Invittox Protocol No. 123: Embryotoxicity Testing in Post-Implantation Embryo Culture- Method of Piersma. 1-2-2008. Available: http://ecvam-dbalm.jrc.ec.europa.eu.
    • Piersma, A.H. Invittox Protocol No. 123: Embryotoxicity Testing in Post-Implantation Embryo Culture- Method of Piersma. 1-2-2008. Available: http://ecvam-dbalm.jrc.ec.europa.eu.
  • 59
    • 0002912254 scopus 로고
    • The kinetics of N-methyl-2-pyrrolidone in pregnant rats and their foetuses compared with non-pregnant rats
    • (Abstract)
    • Ravn-Jonsen A., Edelfors S., Hass U., and Lund S.P. The kinetics of N-methyl-2-pyrrolidone in pregnant rats and their foetuses compared with non-pregnant rats. Toxicol. Lett. Suppl. 136 (1992) (Abstract)
    • (1992) Toxicol. Lett. , vol.SUPPL. 136
    • Ravn-Jonsen, A.1    Edelfors, S.2    Hass, U.3    Lund, S.P.4
  • 60
    • 0036051777 scopus 로고    scopus 로고
    • Developmental toxicity of N-methyl-2-pyrrolidone administered orally to rats
    • Saillenfait A.M., Gallissot F., Langonne I., and Sabate J.P. Developmental toxicity of N-methyl-2-pyrrolidone administered orally to rats. Food Chem. Toxicol. 40 11 (2002) 1705-1712
    • (2002) Food Chem. Toxicol. , vol.40 , Issue.11 , pp. 1705-1712
    • Saillenfait, A.M.1    Gallissot, F.2    Langonne, I.3    Sabate, J.P.4
  • 61
    • 0037400133 scopus 로고    scopus 로고
    • Developmental toxicity of N-methyl-2-pyrrolidone in rats following inhalation exposure
    • Saillenfait A.M., Gallissot F., and Morel G. Developmental toxicity of N-methyl-2-pyrrolidone in rats following inhalation exposure. Food Chem. Toxicol. 41 4 (2003) 583-588
    • (2003) Food Chem. Toxicol. , vol.41 , Issue.4 , pp. 583-588
    • Saillenfait, A.M.1    Gallissot, F.2    Morel, G.3
  • 62
    • 34547919588 scopus 로고    scopus 로고
    • Developmental toxic effects of N-ethyl-2-pyrrolidone administered orally to rats
    • Saillenfait A.M., Gallissot F., and Sabate J.P. Developmental toxic effects of N-ethyl-2-pyrrolidone administered orally to rats. J. Appl. Toxicol. 27 5 (2007) 491-497
    • (2007) J. Appl. Toxicol. , vol.27 , Issue.5 , pp. 491-497
    • Saillenfait, A.M.1    Gallissot, F.2    Sabate, J.P.3
  • 63
    • 0029621915 scopus 로고
    • Developmental toxicity of trichloroethylene, tetrachloroethylene and four of their metabolites in rat whole embryo culture
    • Saillenfait A.M., Langonne I., and Sabate J.P. Developmental toxicity of trichloroethylene, tetrachloroethylene and four of their metabolites in rat whole embryo culture. Arch. Toxicol. 70 2 (1995) 71-82
    • (1995) Arch. Toxicol. , vol.70 , Issue.2 , pp. 71-82
    • Saillenfait, A.M.1    Langonne, I.2    Sabate, J.P.3
  • 64
    • 36148987986 scopus 로고    scopus 로고
    • Comparative developmental toxicities of the three major metabolites of N-methyl-2-pyrrolidone after oral administration in rats
    • Saillenfait A.M., Sabate J.P., and Gallissot F. Comparative developmental toxicities of the three major metabolites of N-methyl-2-pyrrolidone after oral administration in rats. J. Appl. Toxicol. 27 6 (2007) 571-581
    • (2007) J. Appl. Toxicol. , vol.27 , Issue.6 , pp. 571-581
    • Saillenfait, A.M.1    Sabate, J.P.2    Gallissot, F.3
  • 66
    • 0021998339 scopus 로고
    • Effects of cyproheptadine on the rat yolk sac membrane and embryonic development in vitro
    • Schmid B.P., and Hauser R.E. Effects of cyproheptadine on the rat yolk sac membrane and embryonic development in vitro. Xenobiotica (Lond.) 15 8-9 (1985) 695-699
    • (1985) Xenobiotica (Lond.) , vol.15 , Issue.8-9 , pp. 695-699
    • Schmid, B.P.1    Hauser, R.E.2
  • 67
    • 2342632535 scopus 로고    scopus 로고
    • Allometric principles for interspecies extrapolation in toxicological risk assessment-empirical investigations
    • Schneider K., Oltmanns J., and Hassauer M. Allometric principles for interspecies extrapolation in toxicological risk assessment-empirical investigations. Regul. Toxicol. Pharmacol. 39 3 (2004) 334-347
    • (2004) Regul. Toxicol. Pharmacol. , vol.39 , Issue.3 , pp. 334-347
    • Schneider, K.1    Oltmanns, J.2    Hassauer, M.3
  • 69
    • 33748462076 scopus 로고    scopus 로고
    • Tissue distribution and excretion of N-methyl-2-pyrrolidone in male and female rats
    • Sitarek K., and Kilanowicz A. Tissue distribution and excretion of N-methyl-2-pyrrolidone in male and female rats. Int. J. Occup. Med. Environ. Health 19 2 (2006) 142-148
    • (2006) Int. J. Occup. Med. Environ. Health , vol.19 , Issue.2 , pp. 142-148
    • Sitarek, K.1    Kilanowicz, A.2
  • 70
    • 0028840527 scopus 로고
    • 1-Methyl-2-pyrrolidone (NMP): reproductive and developmental toxicity study by inhalation in the rat
    • Solomon H.M., Burgess B.A., Kennedy G.L.J., and Staples R.E. 1-Methyl-2-pyrrolidone (NMP): reproductive and developmental toxicity study by inhalation in the rat. Drug Chem. Toxicol. 18 4 (1995) 271-293
    • (1995) Drug Chem. Toxicol. , vol.18 , Issue.4 , pp. 271-293
    • Solomon, H.M.1    Burgess, B.A.2    Kennedy, G.L.J.3    Staples, R.E.4
  • 71
    • 0002681399 scopus 로고    scopus 로고
    • [ERGATT/ECVAM workshop on acceptance of validated alternative methods: Amden III]
    • Spielmann H., Liebsch M., and Reinhardt C. [ERGATT/ECVAM workshop on acceptance of validated alternative methods: Amden III]. ALTEX 15 1 (1998) 18-22
    • (1998) ALTEX , vol.15 , Issue.1 , pp. 18-22
    • Spielmann, H.1    Liebsch, M.2    Reinhardt, C.3
  • 72
    • 53449100719 scopus 로고    scopus 로고
    • Embryotoxicity hazard assessment of cadmium and arsenic compounds using embryonic stem cells
    • Stummann T.C., Hareng L., and Bremer S. Embryotoxicity hazard assessment of cadmium and arsenic compounds using embryonic stem cells. Toxicology 252 1-3 (2008) 118-122
    • (2008) Toxicology , vol.252 , Issue.1-3 , pp. 118-122
    • Stummann, T.C.1    Hareng, L.2    Bremer, S.3
  • 73
    • 0030971749 scopus 로고    scopus 로고
    • A review of the contribution of whole embryo culture to the determination of hazard and risk in teratogenicity testing
    • Webster W.S., Brown-Woodman P.D., and Ritchie H.E. A review of the contribution of whole embryo culture to the determination of hazard and risk in teratogenicity testing. Int. J. Dev. Biol 41 2 (1997) 329-335
    • (1997) Int. J. Dev. Biol , vol.41 , Issue.2 , pp. 329-335
    • Webster, W.S.1    Brown-Woodman, P.D.2    Ritchie, H.E.3
  • 74
    • 0023924994 scopus 로고
    • Disposition and metabolism of double-labeled [3H and 14C] N-methyl-2-pyrrolidinone in the rat
    • Wells D.A., and Digenis G.A. Disposition and metabolism of double-labeled [3H and 14C] N-methyl-2-pyrrolidinone in the rat. Drug Metab. Dispos. 16 2 (1988) 243-249
    • (1988) Drug Metab. Dispos. , vol.16 , Issue.2 , pp. 243-249
    • Wells, D.A.1    Digenis, G.A.2
  • 75
    • 0026511542 scopus 로고
    • Isolation and identification of the major urinary metabolite of N-methylpyrrolidinone in the rat
    • Wells D.A., Hawi A.A., and Digenis G.A. Isolation and identification of the major urinary metabolite of N-methylpyrrolidinone in the rat. Drug Metab. Dispos. 20 1 (1992) 124-126
    • (1992) Drug Metab. Dispos. , vol.20 , Issue.1 , pp. 124-126
    • Wells, D.A.1    Hawi, A.A.2    Digenis, G.A.3
  • 76
    • 34147106115 scopus 로고    scopus 로고
    • The embryonic stem cell test for the early selection of pharmaceutical compounds
    • Whitlow S., Burgin H., and Clemann N. The embryonic stem cell test for the early selection of pharmaceutical compounds. ALTEX 24 1 (2007) 3-7
    • (2007) ALTEX , vol.24 , Issue.1 , pp. 3-7
    • Whitlow, S.1    Burgin, H.2    Clemann, N.3
  • 78
    • 0011280160 scopus 로고
    • Development: rat
    • Growth Including Reproduction and Morphological Development. Altman P.L., and Dittmer D.S. (Eds) Washington, D.C.
    • Witschi E. Development: rat. In: Altman P.L., and Dittmer D.S. (Eds). Growth Including Reproduction and Morphological Development. Fed. Am. Soc. Exp. Biol. (1962) 304-314 Washington, D.C.
    • (1962) Fed. Am. Soc. Exp. Biol. , pp. 304-314
    • Witschi, E.1
  • 79
    • 0034533734 scopus 로고    scopus 로고
    • A linear pharmacokinetic model predicts usefulness of N-methyl-2-pyrrolidone (NMP) in plasma or urine as a biomarker for biological monitoring for nmp exposure
    • Xiaofei E., Yasuhiko W., Jun-ichi N., Hiroyuki M., Shigeru T., Yukio S., and Akio K. A linear pharmacokinetic model predicts usefulness of N-methyl-2-pyrrolidone (NMP) in plasma or urine as a biomarker for biological monitoring for nmp exposure. J. Occup. Health. 42 (2000) 321-327
    • (2000) J. Occup. Health. , vol.42 , pp. 321-327
    • Xiaofei, E.1    Yasuhiko, W.2    Jun-ichi, N.3    Hiroyuki, M.4    Shigeru, T.5    Yukio, S.6    Akio, K.7


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