Embryotoxic potential of N-methyl-pyrrolidone (NMP) and three of its metabolites using the rat whole embryo culture system

Toxicology and Applied Pharmacology

Volumn 237, Issue 2, 2009, Pages 154-167

  Flick, Burkhard ^a   Talsness, Chris E ^a   Jäckh, Rudolf ^b   Buesen, Roland ^b   Klug, Stephan ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b BASF SE   (Germany)

Author keywords

2 hydroxy N methylsuccinimide (2 HMSI); 5 hydroxy N methyl pyrrolidone (5 HNMP); balb c 3T3 cytotoxicity test; In vitro; N methyl 2 pyrrolidone (NMP); N methylsuccinimide (MSI); Whole embryo culture

Indexed keywords

1 METHYL 2 PYRROLIDINONE; 2 HYDROXY N METHYLSUCCINIMIDE; 5 HYDROXY N METHYLPYRROLIDONE; DRUG METABOLITE; N METHYLSUCCINIMIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DEVELOPMENTAL STAGE; EMBRYO; EMBRYO CULTURE; EMBRYO DEVELOPMENT; EMBRYOTOXICITY; FETOTOXICITY; NONHUMAN; RAT; TERATOLOGY; VALIDATION PROCESS;

ANIMALS; BALB 3T3 CELLS; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO CULTURE TECHNIQUES; EMBRYO, MAMMALIAN; MICE; PYRROLIDINES; RATS; RATS, WISTAR; TERATOGENS; TOXICITY TESTS;

ORYCTOLAGUS CUNICULUS; RATTUS;

EID: 67349127926     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2009.02.024     Document Type: Article

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