Gene-gene and gene-environment interactions determine risk of thrombosis in families with inherited antithrombin deficiency

Blood

Volumn 94, Issue 8, 1999, Pages 2590-2594

  Van Boven, H H ^b   Vandenbroucke, J P ^b   Briet E ^b   Rosendaal, F R ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 5;

ADOLESCENT; ADULT; AGED; ANTICOAGULATION; ANTITHROMBIN DEFICIENCY; ARTICLE; ENVIRONMENTAL FACTOR; FEMALE; GENETIC PREDISPOSITION; HUMAN; INHERITANCE; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PRIORITY JOURNAL; RISK FACTOR; THROMBOSIS;

EID: 0032829036     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v94.8.2590.420k40_2590_2594     Document Type: Article

References (20)

1. Egeberg O: Inherited antithrombin deficiency causing thrombophilia. Thromb Diath Haemorrh 13:516, 1965
2. Thaler E, Lechner K: Antithrombin III deficiency and thromboembolism. Clin Haematol 10:369, 1981
3. Cosgriff TM, Bishop DT, Hershgold EJ, Skolnick MH, Martin BA, Baty BJ, Carlson KS: Familial antithrombin III deficiency: Its natural history, genetics, diagnosis and treatment. Medicine 62:209, 1983
4. Hirsh J, Piovella F, Pini M: Congenital antithrombin III deficiency. Incidence and clinical features. Am J Med 87:34S, 1989
5. Demers C, Ginsberg JS, Hirsh J, Henderson P, Blajchman MA: Thrombosis in antithrombin-III-deficient persons. Report of a large kindred and literature review. Ann Intern Med 116:754, 1992
6. Koster T, Rosendaal FR, Briët E, van der Meer FJ, Colly LP, Trienekens PH, Poort SR, Reitsma PH, Vandenbroucke JP: Protein C deficiency in a controlled series of unselected outpatients: An infrequent but clear risk factor for venous thrombosis Leiden Thrombophilia Study (LETS). Blood 85:2756, 1995
7. McColl M, Tait RC, Walker ID, Perry DJ, McCall F, Conkie JA: Low thrombosis rate seen in blood donors and their relatives with inherited deficiencies of antithrombin and protein C: Correlation with type of defect, family history, and absence of the factor V Leiden mutation. Blood Coagul Fibrinol 7:689, 1996
8. Lensen RPM, Rosendaal FR, Koster T, Allaart CF, de Ronde H, Vandenbroucke JP, Reitsma PH, Bertina RM: Apparent different thrombotic tendency in patients with factor V Leiden and protein C deficiency due to selection of patients. Blood 88:4205, 1996
9. Vandenbroucke JP, Koster T, Briët E, Reitsma PH, Bertina RM, Rosendaal FR: Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation. Lancet 344:1453, 1994
10. Ridker PM, Glynn RJ, Miletich JP, Goldhaber SZ, Stampfer MJ, Hennekens CH: Age-specific incidence rates of venous thromboembolism among heterozygous carriers of factor V Leiden mutation. Ann Intern Med 126:528, 1997
11. Ridker PM, Hennekens CH, Selhub J, Miletich JP, Malinow MR, Stampfer MJ: Interrelation of hyperhomocyst(e)nemia, factor V Leiden, and risk of future venous thromboembolism. Circulation 95:1777, 1997
12. van Boven HH, Reitsma PH, Rosendaal FR, Bayston TA, Chowdhury V, Bauer KA, Scharrer I, Conard J, Lane DA: Factor V Leiden (FV R506Q) in families with inherited antithrombin deficiency. Thromb Haemost 75:417, 1996
13. Laurell CB: Quantitative estimation of proteins by electrophoresis in agarose gels containing antibodies. Anal Biochem 15:45, 1966
14. van Boven HH, Olds RJ, Thein SL, Reitsma PH, Lane DA, Briët E, Vandenbroucke JP, Rosendaal FR: Hereditary antithrombin deficiency: Heterogeneity of the molecular basis and mortality in Dutch families. Blood 84:4209, 1994
15. Poort SR, Rosendaal FR, Reitsma PH, Bertina RM: A common genetic variation in the 3′-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood 88:3698, 1996
16. Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma PH: Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature 369:64, 1994
17. Allaart CF, Poort SR, Rosendaal FR, Reitsma PH, Bertina RM, Briët E: Increased risk of venous thrombosis in carriers of hereditary protein C deficiency defect. Lancet 341:134, 1993
18. Frezzato M, Tosetto A, Rodeghiero F: Validated questionnaire for the identification of previous personal or familial venous thromboembolism. Am J Epidemiol 143:1257, 1996
19. van der Meer FJM, Rosendaal FR, Vandenbroucke JP, Briët E: Bleeding complications in oral anticoagulant therapy. An analysis of risk factors. Arch Intern Med 153:1557, 1993
20. Palareti G, Leali N, Coccheri S, Poggi M, Manotti C, D'Angelo A, Pengo V, Erba N, Moia M, Ciavarella N, Devote G, Berrettini M, Musolesi S: Bleeding complications of oral anticoagulant treatment: an inception-cohort, prospective collaborative study (ISCOAT). Italian Study on Complications of Oral Anticoagulant Therapy. Lancet 348: 423, 1996