The high rate of familial lichen sclerosus suggests a genetic contribution: An observational cohort study

Journal of the European Academy of Dermatology and Venereology

Volumn 24, Issue 9, 2010, Pages 1031-1034

  Sherman, V ^a   McPherson, T ^a   Baldo, M ^a   Salim, A ^b   Gao, Xh ^c   Wojnarowska, F ^a  

^a CHURCHILL HOSPITAL   (United Kingdom)

^b BIRMINGHAM HEARTLANDS HOSPITAL   (United Kingdom)

^c CHINA MEDICAL UNIVERSITY   (China)

Author keywords

autoimmune; familial; lichen sclerosus; vulval cancer

Indexed keywords

ARTICLE; AUTOIMMUNE DISEASE; CIRCUMCISION; COHORT ANALYSIS; CONTROLLED STUDY; FAMILIAL DISEASE; FAMILY HISTORY; FEMALE; GENETIC SUSCEPTIBILITY; HUMAN; LICHEN SCLEROSUS ET ATROPHICUS; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RISK FACTOR; UNIVERSITY HOSPITAL; VULVA CANCER;

COHORT STUDIES; FEMALE; HUMANS; INCIDENCE; LICHEN SCLEROSUS ET ATROPHICUS; MALE; PEDIGREE; VULVAR DISEASES;

EID: 77955257796     PISSN: 09269959     EISSN: 14683083     Source Type: Journal    
DOI: 10.1111/j.1468-3083.2010.03572.x     Document Type: Article

References (31)

1. Montgomery H, Hill WR. Lichen sclerosus et atrophicus. Arch Derm Syphilol 1940 42 : 755 779.
2. Wallace HJ. Lichen sclerosus et atrophicus. Trans St Johns Hosp Dermatol Soc 1971 57 : 9 30.
3. Tasker GL, Wojnarowska F. Lichen sclerosus. Clin Exp Dermatol 2003 28 : 128 133.
4. Powell J, Wojnarowska F. Childhood vulvar lichen sclerosus: an increasingly common problem. J Am Acad Dermatol 2001 44 : 803 806.
5. Cooper SM, Gao XH, Powell JJ, Wojnarowska F. Does treatment of vulvar lichen sclerosus influence its prognosis? Arch Dermatol 2004 140 : 702 706.
6. Marren P, Yell J, Charnock FM, Bunce M, Welsh K, Wojnarowska F. The association between lichen sclerosus and antigens of the HLA system. Br J Dermatol 1995 132 : 197 203.
7. Powell J, Wojnarowska F, Winsey S, Welsh K. Lichen sclerosus premenarche: autoimmunity and immunogenetics. Br J Dermatol 2000 142 : 481 484.
8. Senturk N, Aydin F, Birinci A et al. Coexistance of HLA-B*08 and HLA-B*18 in four siblings with Lichen sclerosus. Dermatology 2004 208 : 64 66.
9. Aslanian FM, Marques MT, Matos HJ et al. HLA markers in familial Lichen Sclerosus. J Dtsch Dermatol Ges 2006 4 : 842 847.
10. Gao XH, Bernardo MC, Winsey S et al. The association between HLA DR, DQ antigens, and vulvar lichen sclerosus in the UK: HLA DRB1*12 and its associated DRB1*12/DQB1*0301/04/09/010 haplotype confers susceptibility to vulvar lichen sclerosus and HLA DRB1*0301/04 and its associated DRB1*0301/04/DQB1*0201/02/03 haplotype protects from vulvar lichen sclerosus. J Invest Dermatol 2005 125 : 895 899.
11. Azurdia RM, Luzzi GA, Byren I et al. Lichen sclerosus in adult men: a study of HLA association and susceptibility to autoimmune disease. Br J Dermatol 1999 140 : 79 83.
12. Cooper SM, Ali I, Bald N, Wojnarowska F. The association of lichen sclerosus and erosive lichen planus of the vulva with autoimmune disease: a case-control study. Arch Dermatol 2008 144 : 1432 1435.
13. Harrington CI, Dunsmore IR. An investigation into the incidence of auto-immune disorders in patients with lichen sclerosus and atrophicus. Br J Dermatol 1981 104 : 563 566.
14. Meyrick Thomas RH, Ridley CM, Mc Gibbon DH, Black MM. Lichen sclerosus et atrophicus and autoimmunity - a study or 350 women. Br J Dermatol 1988 118 : 41 46.
15. Oyama N, Chan I, Neill SM et al. Autoantibodies to extracellular matrix protein 1 in lichen sclerosus. Lancet 2003 362 : 118 123.
16. Baldo M, Bailey A, Bhogal B, Groves RW, Ogg G, Wojnarowska F. T cells reactive with the NC16A domain of BP180 are present in vulval lichen sclerosus and lichen planus. J Eur Acad Dermatol Venereo 2010 24 : 186 190.
17. Meyrick Thomas RH, Kennedy CT. The development of lichen sclerosis et atrophicus in monozygotic twin girls. Br J Dermatol 1986 114 : 377 379.
18. Fallick ML, Faller G, Klauber GT. Balanitis xerotica obliterans in monozygotic twins. Br J Urol 1997 79 : 810.
19. Kiss A. Balanitis xerotica obliterans in monozygotic twins. Br J Urol 1997 80 : 969.
20. Hunt E. Disease Affecting the Vulva, 3rd edn. CV Mosby, St Louis, 1948.
21. Barker LP, Gross P. Lichen sclerosus et atrophicus of the female genitalia. Arch Dermatol 1962 85 : 362 373.
22. Hofs VW. Special clinical observations of lichcen sclerosus et atrophicus. Dermatol Monatsschr 1978 164 : 633.
23. Murphy FR, Lipa M, Haberman HF. Familial vulvar dystrophy of lichen sclerosus type. Arch Dermatol 1982 118 : 329 331.
24. Friedrich EG, MacLauren NK. Genetic aspects of vulvar lichen sclerosus. Am J Obstet Gynecol 1984 150 : 161 166.
25. Cox NH, Mitchell JN, Morley WN. Lichen sclerosus et atrophicus in non-identical female twins. Br J Dermatol 1986 115 : 743 746.
26. Shirer JA Jr., Ray MC. Familial occurrence of lichen sclerosus et atrophicus. Case reports of a mother and daughter. Arch Dermatol 1987 123 : 485 488.
27. Hagedorn M. Genital vulvar lichen sclerosis in 2 siblings. Z Hautkr 1989 64 : 813 814.
28. Sahn EE, Bluestein EL, Olivia S. Familial lichen sclerosus et atrophicus in childhood. Pediatr Dermatol 1994 11 : 160 163.
29. Fitzgerald EA, Connelly CS, Purcell SM, Kantor GR. Familial lichen sclerosus et atrophicus in association with CREST syndrome: a case report. Br J Dermatol 1996 134 : 1144 1146.
30. Powell JJ, Wojnarowska F. Lichen sclerosus. Lancet 1999 353 : 1777 1783.
31. Sanders CS, Ali I, Dean D, Thiele JJ, Wojnarowska F. Oxidative stress is implicated in the pathogenesis of lichen sclerosus. Br J Dermatol 2004 151 : 627 635.