The association between HLA DR, DQ antigens, and vulval lichen sclerosus in the UK: HLA DRB1*12 and its associated DRB1*12/DQB1*0301/04/ 09/010 haplotype confers susceptibility to vulval lichen sclerosus, and HLA DRB1*0301/04 and its associated DRB1*0301/04/DQB1*0201/02/03 haplotype protects from vulval lichen sclerosus

Journal of Investigative Dermatology

Volumn 125, Issue 5, 2005, Pages 895-899

  Gao, Xing Hua ^a   Barnardo, Martin C M N ^b   Winsey, Samantha ^b   Ahmad, Tariq ^b   Cook, Julia ^b   Agudelo, Juliet D ^b   Zhai, Ning ^a   Powell, Jenny J ^b   Fuggle, Susan V ^b   Wojnarowska, Fenella ^b  

^a CHINA MEDICAL UNIVERSITY   (China)

^b CHURCHILL HOSPITAL   (United Kingdom)

Author keywords

Genotyping; HLA DQ; HLA DR; Lichen sclerosus; Susceptibility

Indexed keywords

HLA DQ ANTIGEN; HLA DQB1 ANTIGEN; HLA DR ANTIGEN; STEROID; HLA DQB1 PROTEIN, HUMAN; HLA-DQB1 PROTEIN, HUMAN; HLA-DRB1 ANTIGEN; MEMBRANE PROTEIN;

ADULT; AGED; ANALYTIC METHOD; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; FISHER EXACT TEST; GENITAL TRACT INFECTION; GENOTYPE; HAPLOTYPE; HUMAN; LICHEN SCLEROSUS ET ATROPHICUS; MAJOR CLINICAL STUDY; PARAMETER; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; STATISTICAL ANALYSIS; UNITED KINGDOM; VALIDATION PROCESS; ADOLESCENT; CASE CONTROL STUDY; CHILD; DISEASE PREDISPOSITION; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETICS; IMMUNOLOGY; INFANT; MIDDLE AGED; ONSET AGE; PATHOLOGY; PRESCHOOL CHILD; VULVA;

ADOLESCENT; ADULT; AGE OF ONSET; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; CHILD; CHILD, PRESCHOOL; DISEASE SUSCEPTIBILITY; FEMALE; GENE FREQUENCY; GREAT BRITAIN; HAPLOTYPES; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMANS; INFANT; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; POLYMORPHISM, GENETIC; STEROIDS; VULVA; VULVAR LICHEN SCLEROSUS;

EID: 33644789833     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2005.23905.x     Document Type: Article

References (26)

1. Azurdia R, Luzzi G, Byren I, et al: Lichen sclerosus in adult men: A study of HLA associations and susceptibility to autoimmune disease. Br J Dermatol 140:79-83, 1999
2. Bakr A, El-Chenawy F: HLA-DQB1 and DRB1 alleles in Egyptian children with steroid nephrotic syndrome. Pediatr Nephrol 12:234-237, 1998
3. Bunce M, O'Neill C, Barnardo M, et al: Phototyping: Comprehensive DNA typing for HLA-A,B,C,DRB1,DRB3,DRB4, DRB5 and DQB1 by PCR with 144 primer mixes utilising sequence-specific primers (PCR-SSCP). Tissue Antigens 46:355-367, 1995
4. Burg SVD, Ressing M, Kwappenberg K, et al: Natural T-helper immunity against human papillomavirus type 16 (HPV 16) E7-derived peptide epitopes in patients with HPV16-positive cervical lesions: Identification of 3 human leukocyte antigen class II-restricted epitopes. Int J Cancer 91:612-618, 2001
5. Cardon L, Bell J: Association study designs for complex diseases. Nat Genet 2:91-99, 2000
6. Carlson J, Gragbowski R, Chichester P, et al: Comparative immunophenotypic study of lichen sclerosus: Epidermotrophic CD56+ lymphocytes are numerous-implications for pathogenesis. Am J Dermatol Pathol 22:7-16, 2000
7. Cooper SM, Gao XH, Powell JJ, Wojnarowska F: Does treatment of vulvar lichen sclerosus influence its prognosis? Arch Dermatol 140:702-706, 2004
8. Dalziel K, Millard P, Wojnarowska F: The treatment of vulval lichen sclerosus with a very potent topical steroid(clobetasol propionate 0.05%) cream. Br J Dermatol 124:461-464, 1991
9. Farrell A, Marren P, Dean D, Wojnarowska F: Lichen sclerosus: Evidence that immunological changes occur at all levels of the skin. Br J Dermatol 140:1087-1092, 1999
10. Gaag RVD, Wiersinga W, Koornneef L, et al: HLA-DR4 associated response to corticosteroids in Graves' ophthalmopathy patients. J Endocrinol Invest 13:489-492, 1990
11. Gambaro G, Anglani F, D'Angelo A: Association studies of genetic polymorphisms and complex disease. Lancet 355:308-311, 2000
12. Howard A, Dean D, Cooper S, et al: Circulating basement membrane zone antibodies are found in lichen sclerosus of the vulva. Austral J Dermatol 45:12-15, 2004
13. Larsen B, King C, Simms M, Skanes V: Major histocompatibility complex phenotypes influence serum testosterone concentration. Rheumatology 39:758-763, 2000
14. Lewis F: Lichen sclerosus and autoimmune disease. J Reprod Med 43:1006, 1998
15. Lukowsky A, Muche J, Sterry W, Audring H: Detection of expanded T cell clones in skin biopsy samples of patients with lichen sclerosus et atrophicus by T cell receptor-r polymerase chain reaction assays. J Invest Dermatol 115:254-259, 2000
16. Marren P, Yell J, Charnock F, et al: The association between lichen sclerosus and antigens of the HLA system. Br J Dermatol 132:197-203, 1995
17. Meyrick Thomas R, Ridney C, Mcgibbon D, Black M: Lichen sclerosus et atrophicus and autoimmunity - a study of 350 women. Br J Dermatol 118:41-46, 1988
18. Ollier W, Spector T, Silman A, et al: Are certain HLA haplotypes responsible for low testosterone levels in male? Dis Markers 7:139-143, 1989
19. Oyama N, Chan I, Neill SM, et al: Autoantibodies to extracellular matrix protein 1 in lichen sclerosus. Lancet 362:118-123, 2003
20. Phelps R, Turner A, Rees A: Direct identification of naturally processed autoantigen-derived peptides bound to HLA-DR15*-. J Biochem 271:18549-18553, 1996
21. Powell J, Wojnarowska F: Lichen sclerosus. Lancet 353:1777-1783, 1999
22. Powell J, Wojnarowska F: Childhood vulvar lichen sclerosus: An increasingly common problem. J Am Acad Dermatol 44:803-806, 2001
23. Powell J, Wojnarowska F, Winsey S, et al: Lichen sclerosus premenarche: Autoimmunity and immunogenetics. Br J Dermatol 142:481-484, 2000
24. Ridley CM: General dermatological conditions and dermatoses of the vulva. In: The Vulva. Edinburg: Churchill Livingstone, 1988; p 172-188
25. Sahn E, Bluestein E, Olive S: Familial lichen sclerosus et atrophicus in childhood. Pediatric Dermatol 11:160-163, 1994
26. Sinha P, Sorinola O, Luesley D: Lichen sclerosus of the vulva: Long-term steroid maintenance therapy. J Reprod Med 44:621-624, 1999