Iron chelation prevents lung injury after major hepatectomy

Hepatology Research

Volumn 40, Issue 8, 2010, Pages 841-850

  Kalimeris, Konstantinos ^a   Nastos, Constantinos ^a   Papoutsidakis, Nikolaos ^a   Xanthopoulou, Marianna N ^a   Defterevos, George ^a   Tympa, Aliki ^a   Pafiti, Agatha ^b   Andreadou, Ioanna ^c   Kostopanagiotou, Georgia ^a   Smyrniotis, Vassilios ^a   Arkadopoulos, Nikolaos ^a  

^a HAROKOPIO UNIVERSITY   (Greece)

^b UNIVERSITY OF ATHENS   (Greece)

^c UNIVERSITY OF ATHENS   (Greece)

Author keywords

Iron regulation; Liver resection; Liver lung interactions; Remote lung injury

Indexed keywords

1 ALKYL 2 ACETYLGLYCEROPHOSPHOCHOLINE ESTERASE; 3 NITROTYROSINE; CARBONYL DERIVATIVE; DEFEROXAMINE; INTERLEUKIN 6; MALONALDEHYDE; NONHEME IRON PROTEIN; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL OXYGEN SATURATION; ARTICLE; CELL INFILTRATION; CONTROLLED STUDY; ENZYME ACTIVITY; EXPERIMENTAL PIG; FEMALE; GAS EXCHANGE; HEMODYNAMIC PARAMETERS; HISTOPATHOLOGY; INFLAMMATORY CELL; IRON CHELATION; LIVER FUNCTION; LIVER ISCHEMIA; LIVER RESECTION; LUNG INJURY; LUNG PARENCHYMA; LUNG VASCULAR RESISTANCE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REPERFUSION;

EID: 77955250380     PISSN: 13866346     EISSN: 1872034X     Source Type: Journal    
DOI: 10.1111/j.1872-034X.2010.00682.x     Document Type: Article

References (36)

1. Váli L, Taba G, Szentmihályi K. Reduced antioxidant level and increased oxidative damage in intact liver lobes during ischaemia-reperfusion. World J Gastroenterol 2006, 12:1086-91.
2. Serrano E, Diaz J, Acosta F, Palenciano CG, Parrilla P, Carbonell LF. Oxidative stress during ischemia-reperfusion in liver transplantation. Transplant Proc 2000, 32:2651.
3. Camargo CA, Madden JF, Gao W, Selvan RS, Clavien PA. Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent. Hepatology 1997, 26:1513-20.
4. Liu PT, Symons AM, Howarth JA, Boulter PS, Parke DV. Studies in surgical trauma: oxidative stress in ischaemia-reperfusion of rat liver. Clin Sci (Lond) 1994, 86:453-60.
5. Kostopanagiotou G, Routsi C, Smyrniotis V. Alterations in bronchoalveolar lavage fluid during ischemia-induced acute hepatic failure in the pig. Hepatology 2003, 37:1130-8.
6. Kostopanagiotou GG, Kalimeris KA, Arkadopoulos NP. Desferrioxamine attenuates minor lung injury following surgical acute liver failure. Eur Respir J 2009, 33:1429-36.
7. Arkadopoulos N, Vlahakos D, Kostopanagiotou G. Iron chelation attenuates intracranial pressure and improves survival in a swine model of acute liver failure. Liver Transpl 2008, 14:1116-24.
8. Colletti LM, Remick DG, Campbell DA. Desferal attenuates TNF release following hepatic ischemia/reperfusion. J Surg Res 1994, 57:447-53.
9. Rebouche CJ, Wilcox CL, Widness JA. Microanalysis of non-heme iron in animal tissues. J Biochem Biophys Methods 2004, 58:239-51.
10. Levine RL, Williams JA, Stadtman ER, Shacter E. Carbonyl assays for determination of oxidatively modified proteins. Methods Enzymol 1994, 233:346-57.
11. McCord JM. Analysis of Superoxide Dismutase Activity in Current Protocols in Toxicology 1999, 7.3.1-7.3.9, New York, John Wiley & Sons
12. Bradford M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of dye-binding. Anal Biochem 1976, 72:248-54.
13. Germann PG, Häfner D. A rat model of acute respiratory distress syndrome (ARDS): Part 1. Time dependency of histological and pathological changes. J Pharmacol Toxicol Methods 1998, 40:101-7.
14. Omar R, Nomikos I, Piccorelli G, Savino J, Agarwal N. Prevention of postischaemic lipid peroxidation and liver cell injury by iron chelation. Gut 1989, 30:510-14.
15. Smyrniotis V, Kostopanagiotou G, Theodoraki K. Ischemic preconditioning versus intermittent vascular inflow control during major liver resection in pigs. World J Surg 2005, 29:930-4.
16. Carrick JB, Martins O, Snider CC. The effect of LPS on cytokine synthesis and lung neutrophil influx after hepatic ischemia/reperfusion injury in the rat. J Surg Res 1997, 68:16-23.
17. Colletti LM, Green M. Lung and liver injury following hepatic ischemia/reperfusion in the rat is increased by exogenous lipopolysaccharide which also increases hepatic TNF production in vivo and in vitro. Shock 2001, 16:312-19.
18. Lin HI, Chou SJ, Wang D, Feng NH, Feng E, Chen CF. Reperfusion liver injury induces down-regulation of eNOS and up-regulation of iNOS in lung tissues. Transplant Proc 2006, 38:2203-6.
19. Ritter C, da Cunha AA, Echer IC. Effects of N-acetylcysteine plus deferoxamine in lipopolysaccharide-induced acute lung injury in the rat. Crit Care Med 2006, 34:471-7.
20. Ghio AJ, Carter JD, Richards JH, Richer LD, Grissom CK, Elstad MR. Iron and iron-related proteins in the lower respiratory tract of patients with acute respiratory distress syndrome. Crit Care Med 2003, 31:395-400.
21. Bartesaghi S, Trujillo M, Denicola A, Folkes L, Wardman P, Radi R. Reactions of desferrioxamine with peroxynitrite-derived carbonate and nitrogen dioxide radicals. Free Rad Biol Med 2004, 36:471-83.
22. Chow CW, Herrera Abreu MT, Suzuki T, Downey GP. Oxidative stress and acute lung injury. Am J Respir Cell Mol Biol 2003, 29:427-31.
23. Xu J, Knutson MD, Carter CS, Leeuwenburgh C. Iron accumulation with age, oxidative stress and functional decline. PLoS ONE 2008, 3:e2865.
24. Hirsch J, Niemann CU, Hansen KC. Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion. Crit Care Med 2008, 36:1846-54.
25. Quinlan T, Spivack S, Mossman BT. Regulation of antioxidant enzymes in lung after oxidant injury. Environ Health Perspect 1994, 102:79-87.
26. Tiberio L, Tiberio GA, Bardella L. Mechanisms of interleukin-6 protection against ischemia-reperfusion injury in rat liver. Cytokine 2006, 34:131-42.
27. Streetz KL, Luedde T, Manns MP, Trautwein C. Interleukin 6 and liver regeneration. Gut 2000, 47:309-12.
28. Cressman DE, Greenbaum LE, DeAngelis RA. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice. Science 1996, 274:1379-83.
29. Wuestefeld T, Klein C, Streetz KL. Interleukin-6/glycoprotein 130-dependent pathways are protective during liver regeneration. J Biol Chem 2003, 278:11281-8.
30. Barton BE, Jackson JV. Protective role of interleukin 6 in the lipopolysaccharide-galactosamine septic shock model. Infect Immun 1993, 61:1496-9.
31. Ulich TR, Yin S, Guo K, Yi ES, Remick D, del Castillo J. Intratracheal injection of endotoxin and cytokines. II. Interleukin-6 and transforming growth factor beta inhibit acute inflammation. Am J Pathol 1991, 138:1097-101.
32. Ward NS, Waxman AB, Homer RJ. Interleukin-6-induced protection in hyperoxic acute lung injury. Am J Respir Cell Mol Biol 2000, 22:535-42.
33. Inoue K, Takano H, Yanagisawa R. Antioxidative role of interleukin-6 in septic lung injury in mice. Int J Immunopathol Pharmacol 2008, 21:501-7.
34. De Keyzer D, Karabina SA, Wei W. Increased PAFAH and oxidized lipids are associated with inflammation and atherosclerosis in hypercholesterolemic pigs. Arterioscler Thromb Vasc Biol 2009, 29:2041-6.
35. Tsai BM, Wang M, Pitcher JM, Meldrum KK, Meldrum DR. Hypoxic pulmonary vasoconstriction and pulmonary artery tissue cytokine expression are mediated by protein kinase C. Am J Physiol Lung Cell Mol Physiol 2004, 287:L1215-19.
36. Walsh TS, Garden OJ, Lee A. Metabolic, cardiovascular, and acid-base status after hepatic artery or portal vein reperfusion during orthotopic liver transplantation. Liver Transpl 2002, 8:537-44.