Phosphomimetic substitution of cytochrome c tyrosine 48 decreases respiration and binding to cardiolipin and abolishes ability to trigger downstream caspase activation

Biochemistry

Volumn 49, Issue 31, 2010, Pages 6705-6714

  Pecina, Petr ^a   Borisenko, Grigory G ^b,c   Belikova, Natalia A ^b   Tyurina, Yulia Y ^b   Pecinova, Alena ^a   Lee, Icksoo ^a   Samhan Arias, Alejandro K ^b   Przyklenk, Karin ^a   Kagan, Valerian E ^b   Hüttemann, Maik ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c FEDERAL RESEARCH AND CLINICAL CENTER OF PHYSICAL CHEMICAL MEDICINE OF FEDERAL MEDICAL BIOLOGICAL AGENCY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIAPOPTOTIC; APOPTOSIS; BINDING AFFINITIES; BOVINE HEART; BOVINE LIVER; CARDIOLIPINS; CASPASE ACTIVATION; CASPASE-3; CELL SIGNALING; CYTOCHROME C; CYTOCHROME C OXIDASE; IN-VIVO; KINETIC ANALYSIS; MITOCHONDRIAL ELECTRON TRANSPORT CHAIN; MULTIPLE FUNCTION; PEROXIDASE ACTIVITIES; REDOX POTENTIALS; TYPE II; TYROSINE PHOSPHORYLATION; WILD TYPES;

AMINO ACIDS; ANTIGENS; BINDING ENERGY; CELL DEATH; LIVER; MAMMALS; PHOSPHATASES; PHOSPHOLIPIDS; PLANTS (BOTANY); REDOX REACTIONS;

PHOSPHORYLATION;

CARDIOLIPIN; CASPASE 3; CYTOCHROME C; CYTOCHROME C OXIDASE; GLUTAMIC ACID; PHENYLALANINE; TYROSINE;

APOPTOSIS; ARTICLE; CHEMICAL REACTION KINETICS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ELECTRON TRANSPORT; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATION REDUCTION POTENTIAL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; RESPIRATORY CHAIN; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CARDIOLIPINS; CASPASES; CATTLE; CELL RESPIRATION; CYTOCHROMES C; MICE; MUTATION; PHOSPHORIC ACID ESTERS; PHOSPHORYLATION; PROTEIN BINDING; RATS; TYROSINE;

BOVINAE; MAMMALIA;

EID: 77955235585     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100486s     Document Type: Article

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