Differential functions of NR2A and NR2B in short-term and long-term memory in rats

NeuroReport

Volumn 21, Issue 12, 2010, Pages 808-811

  Jung, Ye Ha ^a   Suh, Yoo Hun ^a  

^a Seoul National University   (South Korea)

Author keywords

NMDA receptor subunits; NR2A and NR2B; right and left forebrain; short term and long term memory

Indexed keywords

N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ESCAPE BEHAVIOR; FOREBRAIN; LONG TERM MEMORY; MAZE TEST; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; RAT; SHORT TERM MEMORY; WESTERN BLOTTING; WISTAR RAT;

ANIMALS; BLOTTING, WESTERN; FUNCTIONAL LATERALITY; GLUTAMIC ACID; LONG-TERM POTENTIATION; MAZE LEARNING; MEMORY; MEMORY, SHORT-TERM; PROSENCEPHALON; RATS; RATS, WISTAR; RECEPTORS, N-METHYL-D-ASPARTATE; RECOGNITION (PSYCHOLOGY); SPACE PERCEPTION; SYNAPTIC TRANSMISSION;

EID: 77955232569     PISSN: 09594965     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNR.0b013e32833ccb0e     Document Type: Article

References (25)

1. Lin WY. NMDA receptors are required in memory formation in Drosophila mushroom body. Biochem Biophys Res Commun 2005; 334:779-786.
2. Woodside BL, Borroni AM, Hammonds MD, Teyler TJ. NMDA receptors and voltage-dependent calcium channels mediate different aspects of acquisition and retention of a spatial memory task. Neurobiol Learn Mem 2004; 81:105-114.
3. Baker KB, Kim JJ. Effects of stress and hippocampal NMDA receptor antagonism on recognition memory in rats. Learn Mem 2002; 9:58-65.
4. Bauer EP, Schafe GE, LeDoux JE. NMDA receptors and L-type voltage-gated calcium channels contribute to long-term potentiation and different components of fear memory formation in the lateral amygdala. J Neurosci 2002; 22:5239-5249.
5. Zhao MG, Toyoda H, Lee YS, Wu LJ, Ko SW, Zhang XH, et al. Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. Neuron 2005; 47:859-872.
6. Tang YP, Shimizu E, Dube GR, Rampon C, Kerchner GA, Zhuo M, et al. Genetic enhancement of learning and memory in mice. Nature 1999; 401:63-69.
7. Fox CJ, Russell KI, Wang YT, Christie BR. Contribution of NR2A and NR2B NMDA subunits to bidirectional synaptic plasticity in the hippocampus in vivo. Hippocampus 2006; 16:907-915.
8. Zhong WX, Dong ZF, Tian M, Cao J, Xu L, Luo JH. N-methyl-D-aspartate receptor-dependent long-term potentiation in CA1 region affects synaptic expression of glutamate receptor subunits and associated proteins in the whole hippocampus. Neuroscience 2006; 141:1399-1413.
9. Liu L, Wong TP, Pozza MF, Lingenhoehl K, Wang Y, Sheng M, et al. Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. Science 2004; 304:1021-1024.
10. Ahmed T, Frey JU. Plasticity-specific phosphorylation of CaMKII, MAP-kinases and CREB during late-LTP in rat hippocampal slices in vitro. Neuropharmacology 2005; 49:477-492.
11. Brightwell JJ, Smith CA, Neve RL, Colombo PJ. Long-term memory for place learning is facilitated by expression of cAMP response element-binding protein in the dorsal hippocampus. Learn Mem 2007; 14:195-199.
12. Pascual A, Preat T. Localization of long-term memory within the Drosophila Mushroom body. Science 2001; 294:1115-1117.
13. Park S. Hemispheric asymmetry of spatial working memory deficit in schizophrenia. Int J Psychophysiol 1999; 34:313-322.
14. Kandel ER, Schwartz JH, Jessell TM. Principles of neural science. 4th ed. New York: McGraw-Hill; 2000. pp. 1233-1237.
15. Van Swinderen B. Attention-like processes in Drosophila require short-term memory genes. Science 2007; 315:1590-1593.
16. Bannerman DM, Niewoehner B, Lyon L, Romberg C, Schmitt WB, Taylor A, et al. NMDA receptor subunit NR2A is required for rapidly acquired spatial working memory but not incremental spatial reference memory. J Neurosci 2008; 28:3623-3630.
17. Kim MJ, Dunah AW, Wang YT, Sheng M. Differential roles of NR2A-and NR2B-containing NMDA receptors in Ras-ERK signaling and AMPA receptor trafficking. Neuron 2005; 46:745-760.
18. Toyoda H, Zhao MG, Zhuo M. Roles of NMDA receptor NR2A and NR2B subtypes for long-term depression in the anterior cingulate cortex. Eur J Neurosci 2005; 22:485-494.
19. Bartlett TE, Bannister NJ, Collett VJ, Dargan SL, Massey PV, Bortolotto ZA, et al. Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of 2-week old rat hippocampus. Neuropharmacology 2007; 52:60-70.
20. Strack S, Colbran RJ. Autophosphorylation-dependent targeting of calcium/calmodulin-dependent protein kinase II by the NR2B subunit of the N-methyl-D-aspartate receptor. J Biol Chem 1998; 273:20689-20692.
21. Strack S, McNeill RB, Colbran RJ. Mechanism and regulation of calcium/calmodulin-dependent protein kinase II targeting to the NR2B subunit of the N-methyl-D-aspartate receptor. J Biol Chem 2000; 275:23798-23806.
22. Mayadevi M, Praseeda M, Kumar KS, Omkumar RV. Sequence determinants on the NR2A and NR2B subunits of NMDA receptor responsible for specificity of phosphorylation by CaMKII. Biochim Biophys Acta 2002; 1598:40-45.
23. Wu Y, Kawakami R, Shinohara Y, Fukaya M, Sakimura K, Mishina M, et al. Target-cell-specific left-right asymmetry of NMDA receptor content in schaffer collateral synapses in epsilon1/NR2A knock-out mice. J Neurosci 2005; 25:9213-9226.
24. Tang YP, Wang H, Feng R, Kyin M, Tsien JZ. Differential effects of enrichment on learning and memory function in NR2B transgenic mice. Neuropharmacology 2001; 41:779-790.
25. Prior H, Lingenauber F, Nitschke J, Gunturkun O. Orientation and lateralized cue use in pigeons navigating a large indoor environment. J Exp Biol 2002; 205:1795-1805.