HMLH1 promoter methylation and JC virus T antigen presence in the tumor tissue of colorectal cancer Israeli patients of different ethnic groups

European Journal of Gastroenterology and Hepatology

Volumn 22, Issue 8, 2010, Pages 938-941

  Niv, Yaron ^a   Vilkin, Alex ^a   Brenner, Baruch ^a   Kendel, Yulia ^a   Morgenstern, Sara ^a   Levi, Zohar ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Colorectal cancer; hMLH1; JC virus; methylation; T antigen

Indexed keywords

BISULFITE; GENOMIC DNA; PROTEIN MLH1; VIRUS T ANTIGEN; MLH1 PROTEIN, HUMAN; NUCLEAR PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ALLELE; AMINO TERMINAL SEQUENCE; ANTIGEN DETECTION; ARTICLE; CANCER INCIDENCE; CANCER PATIENT; CANCER TISSUE; CLINICAL ARTICLE; COLORECTAL CANCER; CONTROLLED STUDY; DNA ISOLATION; DNA METHYLATION; DNA SEQUENCE; DNA TEMPLATE; ETHNIC GROUP; GENE AMPLIFICATION; GEOGRAPHIC DISTRIBUTION; HUMAN; HUMAN TISSUE; ISRAEL; JC VIRUS; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN METHYLATION; AGED; COLORECTAL NEOPLASMS; FEMALE; GENETICS; INCIDENCE; ISOLATION AND PURIFICATION; JEW; MALE; MIDDLE AGED; PROMOTER REGION; VERY ELDERLY; VIROLOGY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AGED; AGED, 80 AND OVER; ANTIGENS, VIRAL, TUMOR; COLORECTAL NEOPLASMS; DNA METHYLATION; FEMALE; HUMANS; INCIDENCE; ISRAEL; JC VIRUS; JEWS; MALE; MIDDLE AGED; NUCLEAR PROTEINS; PROMOTER REGIONS, GENETIC;

EID: 77955228475     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/MEG.0b013e32832e9d2c     Document Type: Article

References (22)

1. Ionov Y, Peinado MA, Malkhosyan S, Shibata D, Perucho M. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 1993; 363:558-561.
2. Thibodeau SN, Bren G, Schaid D. Microsatellite instability in cancer of the proximal colon. Science 1993; 260:816-819.
3. Aaltonen LA, Peltomaki P, Leach FS, Sistonen P, Pylkkänen L, Mecklin JP, et al. Clues to the pathogenesis of familial colorectal cancer. Science 1993; 260:812-816.
4. Carethers JM, Boland CR. Neoplasia of the gastrointestinal tract. In: Yamada T, Alpers DH, Kaplowitz N, Laine L, Owyang C, Powell DW, editors. Textbook of Gastroenterology. Philadelphia: Lippincott-Raven; 2003. pp. 557-583.
5. Herman JG, Umar A, Polyak K, Graff JR, Ahuja N, Issa JP, et al. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A 1998; 95:6870-6875.
6. Viegl ML, Kasturi L, Olechnowicz J, Ma AH, Lutterbaugh JD, Periyasamy S, et al. Biallelic inactivation of hMLH1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers. Proc Natl Acad Sci U S A 1998; 95:8698-8702.
7. Lothe RA, Peltomaki P, Meling GI, Aaltonen LA, Nyström-Lahti M, Pylkkänen L, et al. Genomic instability in colorectal cancer: relationship to clinicopathological variables and family history. Cancer Res 1993; 53:5849-5852.
8. Gryfe R, Kim H, Hsieh ETK, Aronson MD, Holowaty EJ, Bull SB, et al. Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer. N Engl J Med 2000; 342:69-77.
9. Halling KC, French AJ, McDonnell SK, Burgart LJ, Schaid DJ, Peterson BJ, et al. Microsatellite instability and 8p allelic imbalance in stage B2 and C colorectal cancers. J Natl Cancer Inst 1999; 91:1295-1303.
10. Lukish JR, Muro K, DeNobile J, Katz R, Williams J, Cruess DF, et al. Prognostic significance of DNA replication errors in young patients with colorectal cancer. Ann Surg 1998; 227:51-56.
11. Wright CM, Dent OF, Barker M, Newland RC, Chapuis PH, Bokey EL, et al. Prognostic significance of extensive microsatellite instability in sporadic clinicopathological stage C. colorectal cancer. Br J Surg 2000; 87:1197-1202.
12. Niv Y, Goel A, Boland CR. JC virus and colorectal cancer: a possible trigger in the chromosomal instability pathway. Curr Opin Gastroenterol 2004; 21:85-89.
13. Goel A, Li MS, Nagasaka T, Shin SK, Fuerst F, Ricciardiello L, et al. Association of JC virus T antigen with the methylator phenotype in sporadic colorectal cancers. Gastroenterology 2006; 130: 1950-1961.
14. Bresalier RS. Malignant neoplasms of the large intestine. In: Feldman M, Friedman LS, Brandt LJ, editors. Sleisenger and Fordtran's gastrointestinal and liver diseases. 8th ed. Philadelphia: Saunders/Elsevier; 2006. pp. 2759-2810.
15. Laghi L, Randolph AE, Chauhan DP, Marra G, Major EO, Neel JV, et al. JC virus DNA is present in the mucosa of the human colon and in colorectal cancers. Proc Natl Acad Sci U S A 1999; 96:7484-7489.
16. Ricciardiello L, Baglioni M, Giovannini C, Pariali M, Cenacchi G, Ripalti A, et al. Induction of chromosomal instability in colonic cells by the human polyoma JC virus. Cancer Res 2003; 63:7256-7262.
17. Goel A, Nagasaka T, Arnold CN, Inoue T, Hamilton C, Niedzwiecki D, et al. The CpG Island Methylator Phenotype and Chromosomal instability is Inversely correlated in sporadic colorectal cancer. Gastroenterology 2007; 132:127-138.
18. Issa JP. CpG island methylator phenotype in cancer. Nat Rev Cancer 2004; 4:988-993.
19. Freedman LS, Edwards BK, Ries LAG, Young JR. Cancer incidence in four member countries (Cyprus, Egypt, Israel, and Jordan) of the middle east cancer consortium (MECC) compared with US SEER. U.S. Department of health and Human Services, National Institutes of Health, http://seer.cancer.gov, MECC monograph. p. 44, 2006.
20. Rozen P, Rosner G, Liphshitz I, Barchana M. The changing incidence and sites of colorectal cancer in the Israeli Arab population and their clinical implications. Int J Cancer 2007; 120:147-151. (Pubitemid 44901929)
21. Boland CR, Luciani MG, Gasche C, Goel A. Infection, inflammation and gastrointestinal cancer. Gut 2005; 54:1321-1331.
22. Shen L, Ahuja N, Shen Y, Habib NA, Toyota M, Rashid A, Issa JP. DNA methylation and environmental exposures in human hepatocellular carcinoma. J Natl Cancer Inst 2002; 94:755-761.