Noninvasive liver steatosis quantification using MRI techniques combined with blood markers

European Journal of Gastroenterology and Hepatology

Volumn 22, Issue 8, 2010, Pages 973-982

  Cesbron Métivier, Elodie ^a   Roullier, Vincent ^a   Boursier, Jérôme ^a,b   Cavaro Ménard, Christine ^a   Lebigot, Jérôme ^a   Michalak, Sophie ^c   Calès, Paul ^a   Aubé, Christophe ^a,b  

^a PRES UNAM   (France)

^b UNIVERSITÉ D'ANGERS   (France)

^c ANGERS UNIVERSITY HOSPITAL   (France)

Author keywords

FSE; liver steatosis; MFGRE; MRI; NAFLD; noninvasive diagnosis; steatosis area

Indexed keywords

ALANINE AMINOTRANSFERASE; TRIACYLGLYCEROL; BIOLOGICAL MARKER;

ADULT; AGED; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALCOHOLIC FATTY LIVER; ARTICLE; AUTOMATION; CLINICAL ARTICLE; CLINICAL EVALUATION; DIAGNOSTIC ACCURACY; ECHOGRAPHY; ELECTRON SPIN RESONANCE; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; MALE; MULTI ECHO GRADIENT ECHO; NON INVASIVE PROCEDURE; NONALCOHOLIC FATTY LIVER; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; TRIACYLGLYCEROL BLOOD LEVEL; BLOOD; FATTY LIVER; IMAGE PROCESSING; MIDDLE AGED; PATHOLOGY; PROCEDURES;

ADULT; AGED; ALANINE TRANSAMINASE; BIOLOGICAL MARKERS; FATTY LIVER; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; TRIGLYCERIDES;

EID: 77955181923     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/MEG.0b013e32833775fb     Document Type: Article

References (46)

1. Cortez-Pinto H, de Moura MC, Day CP. Non-alcoholic steatohepatitis: from cell biology to clinical practice. J Hepatol 2006; 44:197-208.
2. Ludwig J, Viggiano TR, McGill DB, Oh BJ. Nonalcoholic steatohepatitis: Mayo Clinic experiences with a hitherto unnamed disease. Mayo Clin Proc 1980; 55:434-438.
3. McCullough AJ. The clinical features, diagnosis and natural history of nonalcoholic fatty liver disease. Clin Liver Dis 2004; 8:521-533. viii.
4. Harrison SA, Torgerson S, Hayashi PH. The natural history of nonalcoholic fatty liver disease: a clinical histopathological study. Am J Gastroenterol 2003; 98:2042-2047.
5. Guiu B, Loffroy R, Ben Salem D, Masson D, Herve G, Petit JM, et al. Liver steatosis and in-out of phase MR imaging: theory and clinical applications at 3T. J Radiol 2007; 88:1845-1853.
6. Ong JP, Younossi ZM, Speer C, Olano A, Gramlich T, Boparai N. Chronic hepatitis C and superimposed nonalcoholic fatty liver disease. Liver 2001; 21:266-271. (Pubitemid 32677383)
7. Illouz F, Roulier V, Rod A, Gallois Y, Pelle CP, Aube C, et al. Distribution of adipose tissue: quantification and relationship with hepatic steatosis and vascular profiles of type 2 diabetic patients with metabolic syndrome. Diabetes Metab 2008; 34:68-74.
8. Ekstedt M, Franzen LE, Mathiesen UL, Thorelius L, Holmqvist M, Bodemar G, et al. Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology 2006; 44:865-873.
9. Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA, Bacon BR. Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol 1999; 94:2467-2474.
10. Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41:1313-1321.
11. Piccinino F, Sagnelli E, Pasquale G, Giusti G. Complications following percutaneous liver biopsy. A multicentre retrospective study on 68 276 biopsies. J Hepatol 1986; 2:165-173.
12. The French METAVIR Cooperative Study Group. Intraobserver and interobserver variations in liver biopsy interpretation in patients with chronic hepatitis C. Hepatology 1994; 20 (1 Pt 1):15-20.
13. Michalak S, Rousselet MC, Bedossa P, Pilette C, Chappard D, Oberti F, et al. Respective roles of porto-septal fibrosis and centrilobular fibrosis in alcoholic liver disease. J Pathol 2003; 201:55-62.
14. Laine F, Bendavid C, Moirand R, Tessier S, Perrin M, Guillygomarch A, et al. Prediction of liver fibrosis in patients with features of the metabolic syndrome regardless of alcohol consumption. Hepatology 2004; 39:1639-1646.
15. Cales P, Laine F, Boursier J, Deugnier Y, Moal V, Oberti F, et al. Comparison of blood tests for liver fibrosis specific or not to NAFLD. J Hepatol 2009; 50:165-173.
16. Roullier V, Cavaro-Menard C, Guillaume C, Aube C. Fuzzy algorithms to extract vacuoles of steatosis on liver histological color images. Conf Proc IEEE Eng Med Biol Soc 2007; 2007:5575-5578.
17. Fishbein MH, Gardner KG, Potter CJ, Schmalbrock P, Smith MA. Introduction of fast MR imaging in the assessment of hepatic steatosis. Magn Reson Imaging 1997; 15:287-293.
18. Kovanlikaya A, Guclu C, Desai C, Becerra R, Gilsanz V. Fat quantification using three-point Dixon technique: in vitro validation. Acad Radiol 2005; 12:636-639. (Pubitemid 40603691)
19. Reeder SB, McKenzie CA, Pineda AR, Yu H, Shimakawa A, Brau AC, et al. Water-fat separation with IDEAL gradient-echo imaging. J Magn Reson Imaging 2007; 25:644-652.
20. Hussain HK, Chenevert TL, Londy FJ, Gulani V, Swanson SD, McKenna BJ, et al. Hepatic fat fraction: MR imaging for quantitative measurement and display-early experience. Radiology 2005; 237:1048-1055.
21. Qayyum A, Goh JS, Kakar S, Yeh BM, Merriman RB, Coakley FV. Accuracy of liver fat quantification at MR imaging: comparison of out-of-phase gradient-echo and fat-saturated fast spin-echo techniques-initial experience. Radiology 2005; 237:507-511.
22. Rousselet MC, Michalak S, Dupre F, Croue A, Bedossa P, Saint-Andre JP, et al. Sources of variability in histological scoring of chronic viral hepatitis. Hepatology 2005; 41:257-264.
23. Alberti KG, Zimmet P, Shaw J. Metabolic syndrome-a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med 2006; 23:469-480.
24. Angulo P, Hui JM, Marchesini G, Bugianesi E, George J, Farrell GC, et al. The NAFLD fibrosis score: a noninvasive system that identifies liver fibrosis in patients with NAFLD. Hepatology 2007; 45:846-854.
25. Poynard T, Ratziu V, Charlotte F, Messous D, Munteanu M, Imbert-Bismut F, et al. Diagnostic value of biochemical markers (NashTest) for the prediction of non alcoholo steato hepatitis in patients with non-alcoholic fatty liver disease. BMC Gastroenterol 2006; 6:34.
26. Ratziu V, Massard J, Charlotte F, Messous D, Imbert-Bismut F, Bonyhay L, et al. Diagnostic value of biochemical markers (FibroTest-FibroSURE) for the prediction of liver fibrosis in patients with non-alcoholic fatty liver disease. BMC Gastroenterol 2006; 6:6.
27. Bedogni G, Bellentani S, Miglioli L, Masutti F, Passalacqua M, Castiglione A, et al. The Fatty Liver Index: a simple and accurate predictor of hepatic steatosis in the general population. BMC Gastroenterol 2006; 6:33.
28. Poynard T, Ratziu V, Naveau S, Thabut D, Charlotte F, Messous D, et al. The diagnostic value of biomarkers (SteatoTest) for the prediction of liver steatosis. Comp Hepatol 2005; 4:10.
29. Saadeh S, Younossi ZM, Remer EM, Gramlich T, Ong JP, Hurley M, et al. The utility of radiological imaging in nonalcoholic fatty liver disease. Gastroenterology 2002; 123:745-750.
30. Yajima Y, Ohta K, Narui T, Abe R, Suzuki H, Ohtsuki M. Ultrasonographical diagnosis of fatty liver: significance of the liver-kidney contrast. Tohoku J Exp Med 1983; 139:43-50.
31. Limanond P, Raman SS, Lassman C, Sayre J, Ghobrial RM, Busuttil RW, et al. Macrovesicular hepatic steatosis in living related liver donors: correlation between CT and histologic findings. Radiology 2004; 230:276-280.
32. Longo R, Ricci C, Masutti F, Vidimari R, Croce LS, Bercich L, et al. Fatty infiltration of the liver. Quantification by 1H localized magnetic resonance spectroscopy and comparison with computed tomography. Invest Radiol 1993; 28:297-302. (Pubitemid 24079682)
33. Longo R, Pollesello P, Ricci C, Masutti F, Kvam BJ, Bercich L, et al. Proton MR spectroscopy in quantitative in vivo determination of fat content in human liver steatosis. J Magn Reson Imaging 1995; 5:281-285.
34. Thomsen C, Becker U,Winkler K, Christoffersen P, Jensen M, Henriksen O. Quantification of liver fat using magnetic resonance spectroscopy. Magn Reson Imaging 1994; 12:487-495.
35. Boesch C, Slotboom J, Hoppeler H, Kreis R. In vivo determination of intramyocellular lipids in human muscle by means of localized 1H-MRspectroscopy. Magn Reson Med 1997; 37:484-493.
36. Schuchmann S, Weigel C, Albrecht L, Kirsch M, Lemke A, Lorenz G, et al. Non-invasive quantification of hepatic fat fraction by fast 1.0, 1.5 and 3.0T MR imaging. Eur J Radiol 2007; 62:416-422.
37. Kovanlikaya A, Mittelman SD, Ward A, Geffner ME, Dorey F, Gilsanz V. Obesity and fat quantification in lean tissues using three-point Dixon MR imaging. Pediatr Radiol 2005; 35:601-607. (Pubitemid 40724032)
38. Guiu B, Loffroy R, Petit JM, Aho S, Ben Salem D, Masson D, et al. Mapping of liver fat with triple-echo gradient echo imaging: validation against 3.0-T proton MR spectroscopy. Eur Radiol 2009; 19:1786-1793.
39. Guiu B, Petit JM, Loffroy R, Ben Salem D, Aho S, Masson D, et al. Quantification of liver fat content: comparison of triple-echo chemical shift gradient-echo imaging and in vivo proton MR spectroscopy. Radiology 2009; 250:95-102.
40. Boursier J, Chaigneau J, Roullier V, Lainé L, Michalak S, Hubert I, et al. Histological and non-invasive quantitation of liver steatosis. J Hepatol 2009; 50 (Suppl 1):S357.
41. Winkfield B, Aubé C, Burtin P, Cales P. Inter-observer and intra-observer variability in hepatology. Eur J Gastroenterol Hepatol 2003; 15:959-966.
42. Dooms GC, Hricak H, Margulis AR, de Geer G. MR imaging of fat. Radiology 1986; 158:51-54.
43. Rosen BR, Carter EA, Pykett IL, Buchbinder BR, Brady TJ. Proton chemical shift imaging: an evaluation of its clinical potential using an in vivo fatty liver model. Radiology 1985; 154:469-472.
44. Henkelman RM. Measurement of signal intensities in the presence of noise in MR images. Med Phys 1985; 12:232-233.
45. Bombardieri G, Conti LR. Pathophysiology of liver circulation with an overview of medical and invasive treatments. Rays 1997; 22:196-210.
46. Boursier J, Chaigneau J, Roullier V, Lainé L, Michalak S, Hubert I et al. Histological and non-invasive quantitation of liver steatosis. J Hepatol 2009; 50 (Suppl 1):S357.