The RASSF8 candidate tumor suppressor inhibits cell growth and regulates the Wnt and NF-κB signaling pathways

Oncogene

Volumn 29, Issue 30, 2010, Pages 4307-4316

  Lock, F E ^a   Underhill Day, N ^a   Dunwell, T ^a   Matallanas, D ^b   Cooper, W ^a   Hesson, L ^a   Recino, A ^c   Ward, A ^c   Pavlova, T ^d   Zabarovsky, E ^d   Grant, M M ^a   Maher, E R ^a   Chalmers, A D ^c   Kolch, W ^b   Latif, F ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b UNIVERSITY COLLEGE DUBLIN   (Ireland)

^c University of Bath   (United Kingdom)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

adherens junctions; lung cancer; RASSF8

Indexed keywords

BETA CATENIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; RASSF PROTEIN; RASSF8 PROTEIN; SMALL INTERFERING RNA; SYNAPTOTAGMIN I; UNCLASSIFIED DRUG; UVOMORULIN; WNT PROTEIN;

ANCHORAGE INDEPENDENT GROWTH; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CELL GROWTH; CELL MEMBRANE; CELL MIGRATION; CYTOSKELETON; EMBRYO; FEMALE; GENE EXPRESSION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN SITU HYBRIDIZATION; LUNG CANCER; LUNG NON SMALL CELL CANCER; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RNA INTERFERENCE; SCID MOUSE; TUMOR SUPPRESSOR GENE; WOUND HEALING;

ADHERENS JUNCTIONS; ANIMALS; CADHERINS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CYTOSKELETON; HUMANS; MICE; MICE, SCID; NF-KAPPA B; PROMOTER REGIONS, GENETIC; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA; TUMOR SUPPRESSOR PROTEINS; WNT PROTEINS; XENOPUS LAEVIS;

MURINAE; MUS;

EID: 77955172247     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2010.192     Document Type: Article

References (26)

1. Brembeck FH, Rosario M, Birchmeier W. (2006). Balancing cell adhesion and Wnt signaling, the key role of beta-catenin. Curr Opin Genet Dev 16: 51-59.
2. Charalambous M, Smith FM, Bennett WR, Crew TE, Mackenzie F, Ward A. (2003). Disruption of the imprinted Grb10 gene leads to disproportionate overgrowth by an Igf2-independent mechanism. Proc Natl Acad Sci USA 100: 8292-8297.
3. Chen L, Johnson RC, Milgram SL. (1998). P-CIP1, a novel protein that interacts with the cytosolic domain of peptidylglycine alpha-amidating monooxygenase, is associated with endosomes. J Biol Chem 273: 33524-33532.
4. Dallol A, Agathanggelou A, Fenton SL, Ahmed-Choudhury J, Hesson L, Vos MD et al. (2004). RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics. Cancer Res 64: 4112-4116.
5. Dallol A, Agathanggelou A, Tommasi S, Pfeifer GP, Maher ER, Latif F. (2005). Involvement of the RASSF1A tumor suppressor gene in controlling cell migration. Cancer Res 65: 7653-7659.
6. Dallol A, Hesson LB, Matallanas D, Cooper WN, O'Neill E, Maher ER et al. (2009). RAN GTPase is a RASSF1A effector involved in controlling microtubule organization. Curr Biol 19: 1227-1232.
7. Debeer P, Schoenmakers EF, Twal WO, Argraves WS, De Smet L, Fryns JP et al. (2002). The fibulin-1 gene (FBLN1) is disrupted in a t(12;22) associated with a complex type of synpolydactyly. J Med Genet 39: 98-104.
8. Dejana E, Rudini N. (2008). Adherens junctions. Curr Biol 18: R1080-2.
9. Deng J, Miller SA, Wang HY, Xia W, Wen Y, Zhou BP et al. (2002). beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer. Cancer Cell 2: 323-334.
10. Deng J, Xia W, Miller SA, Wen Y, Wang HY, Hung MC. (2004). Crossregulation of NF-kappaB by the APC/GSK-3beta/beta-catenin pathway. Mol Carcinog 39: 139-146.
11. Downward J. (2009). Cancer: A tumour gene's fatal flaws. Nature 462: 44-45.
12. Falvella FS, Manenti G, Spinola M, Pignatiello C, Conti B, Pastorino U et al. (2006). Identification of RASSF8 as a candidate lung tumor suppressor gene. Oncogene 25: 3934-3938.
13. Hayden MS, Ghosh S. (2008). Shared principles in NF-kappaB signaling. Cell 132: 344-362.
14. Hesson LB, Cooper WN, Latif F. (2007a). The role of RASSF1A methylation in cancer. Dis Markers 23: 73-87.
15. Hesson LB, Cooper WN, Latif F. (2007b). Evaluation of the 3p21.3 tumour-suppressor gene cluster. Oncogene 26: 7283-7301.
16. Hesson LB, Dunwell TL, Cooper WN, Catchpoole D, Brini AT, Chiaramonte R et al. (2009). The novel RASSF6 and RASSF10 candidate tumour suppressor genes are frequently epigenetically inactivated in childhood leukaemias. Mol Cancer 8: 42.
17. Katagiri K, Maeda A, Shimonaka M, Kinashi T. (2003). RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1. Nat Immunol 4: 741-748.
18. Langton PF, Colombani J, Chan EH, Wepf A, Gstaiger M, Tapon N. (2009). The dASPP-dRASSF8 complex regulates cell-cell adhesion during drosophila retinal morphogenesis. Curr Biol 19: 1969-1978.
19. MacDonald BT, Tamai K, He X. (2009). Wnt/beta-catenin signaling: components, mechanisms, and diseases. Dev Cell 17: 9-26.
20. Richter AM, Pfeifer GP, Dammann RH. (2009). The RASSF proteins in cancer; from epigenetic silencing to functional characterization. Biochim Biophys Acta 1796: 114-128.
21. Rodriguez-Viciana P, Sabatier C, McCormick F. (2004). Signaling specificity by Ras family GTPases is determined by the full spectrum of effectors they regulate. Mol Cell Biol 24: 4943-4954.
22. Scheel H, Hofmann K. (2003). A novel interaction motif, SARAH, connects three classes of tumor suppressor. Curr Biol 13: R899R900.
23. Sherwood V, Manbodh R, Sheppard C, Chalmers AD. (2008). RASSF7 is a member of a new family of RAS association domain-containing proteins and is required for completing mitosis. Mol Biol Cell 19: 1772-1782.
24. Solanas G, Porta-de-la-Riva M, Agust C, Casagolda D, Sanchez-Aguilera F, Larriba MJ et al. (2008). E-cadherin controls beta-catenin and NF-kappaB transcriptional activity in mesenchymal gene expression. J Cell Sci 121(Pt 13): 2224-2234.
25. Vos MD, Martinez A, Elam C, Dallol A, Taylor BJ, Latif F et al. (2004). A role for the RASSF1A tumor suppressor in the regulation of tubulin polymerization and genomic stability. Cancer Res 64: 4244-4250.
26. Wang F, Grigorieva EV, Li J, Senchenko VN, Pavlova TV, Anedchenko EA et al. (2008). HYAL1 and HYAL2 inhibit tumour growth in vivo but not in vitro. PLoS One 3: e3031.