Plasma rich in growth factors as a therapeutic agent for persistent corneal epithelial defects

Cornea

Volumn 29, Issue 8, 2010, Pages 843-848

  López Plandolit, Silvia ^a,b   Morales, María Celia ^a   Freire, Vanessa ^a   Etxebarría, Jaime ^a,c   Durán, Juan A ^a,d  

^a Instituto Clínico Quirúrgico Oftalmológico   (Spain)

^b Hospital de San Eloy   (Spain)

^c HOSPITAL DE CRUCES   (Spain)

^d UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

Author keywords

growth factor; neurotrophic corneal ulcer; persistent epithelial defect; plasma rich in growth factors

Indexed keywords

ANTIBIOTIC AGENT; ANTIVIRUS AGENT; CORTICOSTEROID; EPITHELIAL GROWTH FACTOR; FIBROBLAST GROWTH FACTOR; GROWTH FACTOR; NERVE GROWTH FACTOR; PLASMA RICH IN GROWTH FACTORS; PLATELET DERIVED GROWTH FACTOR; SCATTER FACTOR; TETRACYCLINE; UNCLASSIFIED DRUG; VASCULOTROPIN; EYE DROPS; SIGNAL PEPTIDE;

ADULT; AGED; AMNION; ARTICLE; AUTOGRAFT; CLINICAL ARTICLE; CORNEA DISEASE; CORNEA EPITHELIUM; DRUG WITHDRAWAL; DRY EYE; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITHELIZATION; ERYTHEMA; EYE BURN; FEMALE; HUMAN; IATROGENIC DISEASE; MALE; PERSISTENT EPITHELIAL DEFECT; PLASMA; PRIORITY JOURNAL; PROSPECTIVE STUDY; PRURITUS; TREATMENT OUTCOME; CORNEAL DISEASES; METABOLISM; MIDDLE AGED; PATHOLOGY; THROMBOCYTE RICH PLASMA; TOPICAL DRUG ADMINISTRATION; VERY ELDERLY; WOUND HEALING;

ADMINISTRATION, TOPICAL; ADULT; AGED; AGED, 80 AND OVER; CORNEAL DISEASES; EPITHELIUM, CORNEAL; FEMALE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIDDLE AGED; OPHTHALMIC SOLUTIONS; PLATELET-RICH PLASMA; PROSPECTIVE STUDIES; TREATMENT OUTCOME; WOUND HEALING;

EID: 77955172106     PISSN: 02773740     EISSN: None     Source Type: Journal    
DOI: 10.1097/ICO.0b013e3181a81820     Document Type: Article

References (28)

1. Tsubota K, Goto E, Shimmura S, et al. Treatment of persistent corneal epithelial defect by autologous serum application. Ophthalmology. 1999; 106:1984-1989.
2. Lopez-Garci'a JS, Garci'a-Lozano I, Rivas L, et al. Aplicaciones del suero autologo en oftalmologla. Arch Soc Esp Oftalmol. 2007;82:9-20.
3. Vajpayee RB, Mukerji N, Tandon R, et al. Evaluation of umbilical cord serum therapy for persistent corneal epithelial defects. Br J Ophthalmol. 2003;87:1312-1316.
4. Anitua E, Andla I, Ardanza B. Autologous platelets as a source of protein for healing and tissue regeneration. Thromb Haemost. 2004;91:4-15. (Pubitemid 38111215)
5. Anitua E, Andia I, Sanchez M, et al. Autologous preparation rich in growth factors promote proliferation and induce VEGF and HGF production by human tendon cells in culture. J Orthop Res. 2005;23:281-286.
6. Marx RE. Platelets rich plasma: evidence to support its use. J Oral Maxillofac Surg. 2004;62:489-496.
7. Cavanagh HD, Colley AM. The molecular basis of neurotrophic keratitis. Acta Ophthalmol. 1989;192(Suppl):115-134.
8. Nishida T, Chikama T, Morishige N, et al. Persistent epithelial defects due to neurotrophic keratopathy treated with a substance P-derived peptide and insulin-like growth factor 1. Jpn J Ophthalmol. 2007;51:442-447.
9. Tripathi BJ, Kwait PS, Tripathi RC. Corneal growth factors: a new generation of ophthalmic pharmaceuticals. Cornea. 1990;9:2-9.
10. Pastor JC, Calonge M. Epidermal growth factor and corneal wound healing. A multicenter study. Cornea. 1992;11:311-314.
11. Murali S, Hardten DR, De Martelaere S, et al. Effect of topically administered platelet-derived growth factor on corneal wound strength. CurrEyeRes. 1994;13:857-862.
12. Nishida T, Ohashi Y, Awata T, et al. Fibronectin. A new therapy for corneal trophic ulcer. Arch Ophthalmol. 1983;101:1046-1048.
13. Phan TM, Foster CS, Boruchoff SA. Topical fibronectin in the treatment of persistent corneal epithelial defects and trophic ulcers. Am J Ophthalmol. 1987;104:494-501.
14. Gordon JF, Johnson P, Musch DC, et al. Topical fibronectin ophthalmic solution in the treatment of persistent defects in the corneal epithelium. Am J Ophthalmol. 1995;119:281-287.
15. Brown SM, Lamberts DW, Reid TW. Neurotrophic and anhidrotic keratopathy treated with substance P and IGF-1. Arch Ophthalmol. 1997; 115:926-927.
16. Nakamura M, Kawahara M, Nakata K, et al. Restoration of corneal epithelial barrier function and wound healing by substance P and IGF-2 in rats with capsaicin-induced neurotrophic keratopathy. Invest Ophthalmol Vis Sci. 2003;44:2937-2940. (Pubitemid 36759755)
17. Bonini S, Lambiase A, Rama P. Topical treatment with nerve growth factor for neurotrophic keratitis. Ophthalmology. 2000;107:1347-1352.
18. Lambiase A, Rama P, Bonini S. Topical treatment with nerve growth factor for corneal neurotrophic ulcers. N Eng J Med. 1998;338:1174-1180.
19. Yamada N, Matsuda R, Morishige N, et al. Open clinical study of eye- drops containing tetrapeptides derived from substance P and insulin-like growth factor 1 for treatment of persistent corneal epithelial defects associated with neurotrophic keratopathy. Br J Ophthalmol. 2008;92:896-900.
20. De Roth A. Plastic repair of conjunctival defects with fetal membrane. Arch Ophthalmol. 1940;23:522-525.
21. Kruse FE, Rohrschneider K, Volcker HE. Multilayer amniotic membrane transplantation for reconstruction of deep corneal ulcers. Ophthalmology. 1999;106:1504-1510.
22. Matsumoto Y, Dogru M, Goto E, et al. Autologous serum application in the treatment of neurotrophic keratopathy. Ophthalmology. 2004;111: 1115-1120.
23. Poon AC, Geerling G, Dart JK, et al. Autologous serum eyedrops for dry eyes and epithelial defects: clinical and in vitro toxicity studies. Br J Ophthalmol. 2001;85:1188-1197.
24. Yoon KC, You IC, Im SK, et al. Application of umbilical cord serum eyedrops for the treatment of neurotrophic keratitis. Ophthalmology. 2007;114:1637-1642.
25. Rocha G, Acera A, Duran JA. Laser in situ keratomileusis flap necrosis after trigeminal nerve palsy. Arch Ophthalmol. 2007;125:1423-1425.
26. Alio J, Abad M, Artola A, et al. Use of autologous platelet-rich plasma in the treatment of dormant corneal ulcers. Ophthalmology. 2007;114:1286-1293.
27. Liu L, Hartwig D, Harloff S, et al. Corneal epitheliotrophic capacity of three different blood-derived preparations. Invest Ophthalmol Vis Sci. 2006;47:2438-2444.
28. Geerling G, MacLennan S, Hartwig D. Autologous serum eye drops for ocular surface disorders. Br J Ophthalmol. 2004;88:1467-1474.