Restoration of corneal epithelial barrier function and wound healing by substance P and IGF-1 in rats with capsaicin-induced neurotrophic keratopathy

Investigative Ophthalmology and Visual Science

Volumn 44, Issue 7, 2003, Pages 2937-2940

  Nakamura, Masatsugu ^a,b   Kawahara, Megumi ^a   Nakata, Katsuhiko ^a   Nishida, Teruo ^b  

^a SANTEN PHARMACEUTICAL CO LTD   (Japan)

^b YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CAPSAICIN; EYE DROPS; SODIUM CHLORIDE; SOMATOMEDIN C; SUBSTANCE P;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; CORNEA EPITHELIUM; DEBRIDEMENT; DRUG EFFECT; FEMALE; FLUOROPHOTOMETRY; KERATOPATHY; LACRIMAL FLUID; MALE; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; RAT; SCHIRMER TEST; WOUND CLOSURE; WOUND HEALING;

ADMINISTRATION, TOPICAL; ANIMALS; BIOLOGICAL TRANSPORT; CAPSAICIN; CORNEA; CORNEAL DISEASES; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; EPITHELIUM, CORNEAL; FEMALE; FLUORESCEIN; FLUOROPHOTOMETRY; INSULIN-LIKE GROWTH FACTOR I; MALE; OPHTHALMIC SOLUTIONS; PREGNANCY; RATS; RATS, WISTAR; SUBSTANCE P; TEARS; TRIGEMINAL NERVE DISEASES; WOUND HEALING;

EID: 0037562790     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.02-0868     Document Type: Article

References (26)

1. Mishima S. The effects of the denervation and the stimulation of the sympathetic and the trigeminal nerve on the mitotic rate of the corneal epithelium in the rabbit. Jpn J Ophthalmol. 1957;1:65-73.
2. Baker KS, Anderson SC, Romanowski EG, et al. Trigeminal ganglion neurons affect corneal epithelial phenotype. Influence on type VII collagen expression in vitro. Invest Ophthalmol Vis Sci. 1993;34:137-144.
3. Araki K, Ohashi Y, Kinoshita S, et al. Epithelial wound healing in the denervated cornea. Curr Eye Res. 1994;13:203-211.
4. Lambiase A, Rama P, Aloe L, et al. Management of neurotrophic keratopathy. Curr Opin Ophthalmol. 1999;10:270-276.
5. Davis EA, Dohlman CH. Neurotrophic keratitis. Int Ophthalmol Clin. 2001;41:1-11.
6. Pushker N, Dada T, Vajpayee RB, et al. Neurotrophic keratopathy. CLAO J. 2001;27:100-107.
7. Nishida T, Nakamura M, Ofuji K, et al. Synergistic effects of substance P with insulin-like growth factor-1 on epithelial migration of the cornea. J Cell Physiol. 1996;169:159-166.
8. Nakamura M, Ofuji K, Chikama T, et al. Combined effects of substance P and insulin-like growth factor-1 on corneal epithelial wound closure of rabbit in vivo. Curr Eye Res. 1997;16:275-278.
9. Brown SM, Lamberts DW, Reid TW, et al. Neurotrophic and anhidrotic keratopathy treated with substance P and insulinlike growth factor 1. Arch Ophthalmol. 1997;115:926-927.
10. Chikama T, Fukuda K, Morishige N, et al. Treatment of neurotrophic keratopathy with substance-P-derived peptide (FGLM) and insulin-like growth factor I. Lancet. 1998;351:1783-1784.
11. Morishige N, Komatsubara T, Chikama T, et al. Direct observation of corneal nerve fibres in neurotrophic keratopathy by confocal biomicroscopy. Lancet. 1999;354:1613-1614.
12. Fujita S, Miyazono Y, Ohba N. Capsaicin-induced corneal changes associated with sensory denervation in neonatal rat. Jpn J Ophthalmol. 1987;31:412-424.
13. Ogilvy CS, Silverberg KR, Borges LF. Sprouting of corneal sensory fibers in rats treated at birth with capsaicin. Invest Ophthalmol Vis Sci. 1991;32:112-121.
14. Fujita S, Shimizu T, Izumi K, et al. Capsaicin-induced neuroparalytic keratitis-like corneal changes in the mouse. Exp Eye Res. 1984;38:165-175.
15. Gallar J, Pozo MA, Rebollo I, et al. Effects of capsaicin on corneal wound healing. Invest Ophthalmol Vis Sci. 1990;31:1968-1974.
16. Yokoi N, Kinoshita S. Clinical evaluation of corneal epithelial barrier function with the slit-lamp fluorophotometer. Cornea. 1995;14:485-489.
17. Virus RM, Gebhart GF. Pharmacologic actions of capsaicin: apparent involvement of substance P and serotonin. Life Sci. 1979;25:1273-1283.
18. Keen P, Tullo AB, Blyth WA, et al. Substance P in the mouse cornea: effects of chemical and surgical denervation. Neurosci Lett. 1982;29:231-235.
19. Nakamura M, Ofuji K, Chikama T, et al. The NK1 receptor and its participation in the synergistic enhancement of corneal epithelial migration by substance P and insulin-like growth factor-1. Br J Pharmacol. 1997;120:547-552.
20. Nakamura M, Chikama T, Nishida T. Up-regulation of integrin α5 expression by combination of substance P and insulin-like growth factor-1 in rabbit corneal epithelial cells. Biochem Biophys Res Commun. 1998;246:777-782.
21. Nakamura M, Nagano T, Chikama T, et al. Up-regulation of phosphorylation of focal adhesion kinase and paxillin by combination of substance P and IGF-1 in SV-40 transformed human corneal epithelial cells. Biochem Biophys Res Commun. 1998;242:16-20.
22. Chikama T, Nakamura M, Nishida T. Up-regulation of integrin α5 by a C-terminus four-amino-acid sequence of substance P (phenyl-alanine-glycine-leucine-methionine-amide) synergistically with insulin-like growth factor-1 in SV-40 transformed human corneal epithelial cells. Biochem Biophys Res Commun. 1999;255:692-697.
23. Unger WG, Butler JM, Cole DF, et al. Substance P, vasoactive intestinal polypeptide (VIP) and somatostatin levels in ocular tissue of normal and sensorily denervated rabbit eyes. Exp Eye Res. 1981;32:797-801.
24. Yamada M, Ogata M, Kawai M, et al. Decreased substance P concentrations in tears from patients with corneal hypesthesia. Am J Ophthalmol. 2000;129:671-672.
25. Lambiase A, Rama P, Bonini S, et al. Topical treatment with nerve growth factor for corneal neurotrophic ulcers. N Engl J Med. 1998;338:1174-1180.
26. Bonini S, Lambiase A, Rama P, et al. Topical treatment with nerve growth factor for neurotrophic keratitis. Ophthalmology. 2000;107:1347-1351.