Endocarditis due to Tropheryma whipplei: Rapid detection, limited genetic diversity, and long-term clinical outcome in a local experience

Clinical Microbiology and Infection

Volumn 16, Issue 8, 2010, Pages 1213-1222

  Escher, R ^a   Roth, S ^a   Droz, S ^a   Egli, K ^b   Altwegg, M ^b   Tauber M G ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b Bio Analytica AG   (Switzerland)

Author keywords

Acridine orange stain; Endocarditis; Genetic diversity; Tropheryma whipplei; Whipple's disease

Indexed keywords

C REACTIVE PROTEIN; CEFTRIAXONE; COTRIMOXAZOLE; ANTIINFECTIVE AGENT; BACTERIAL DNA;

ADULT; AGED; ANEMIA; ARTHRALGIA; ARTICLE; BACTERIAL ENDOCARDITIS; BACTERIAL STRAIN; BACTERIUM DETECTION; BACTERIUM IDENTIFICATION; CASE REPORT; CLINICAL FEATURE; CONTROLLED STUDY; DNA ISOLATION; EARLY DIAGNOSIS; ERYTHROCYTE SEDIMENTATION RATE; FOLLOW UP; GENETIC ANALYSIS; GENETIC VARIABILITY; GENOTYPE; HEART VALVE; HUMAN; INTESTINE BIOPSY; INTESTINE LIPODYSTROPHY; LONG TERM CARE; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SYSTEMATIC REVIEW; TREATMENT DURATION; TROPHERYMA WHIPPELII; WASTING SYNDROME; ACTINOMYCETALES INFECTIONS; CLASSIFICATION; DRUG EFFECTS; ENDOCARDITIS, BACTERIAL; FEMALE; GENETICS; INTRAVENOUS DRUG ADMINISTRATION; ISOLATION AND PURIFICATION; MICROBIOLOGY; MIDDLE AGED; ORAL DRUG ADMINISTRATION; TIME; TREATMENT OUTCOME; TROPHERYMA; VERY ELDERLY;

ACTINOMYCETALES INFECTIONS; ADMINISTRATION, ORAL; ADULT; AGED; AGED, 80 AND OVER; ANTI-BACTERIAL AGENTS; DNA, BACTERIAL; ENDOCARDITIS, BACTERIAL; FEMALE; FOLLOW-UP STUDIES; GENETIC VARIATION; HUMANS; INJECTIONS, INTRAVENOUS; MALE; MIDDLE AGED; TIME FACTORS; TREATMENT OUTCOME; TROPHERYMA;

EID: 77955166111     PISSN: 1198743X     EISSN: 14690691     Source Type: Journal    
DOI: 10.1111/j.1469-0691.2009.03038.x     Document Type: Article

References (54)

1. Whipple G. A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and mesenteric lymphatic tissues. Bull Johns Hopkins Hosp 1907, 18:382-391.
2. Enzinger FM, Helwig EB. Whipple's disease. A review of the literature and report of fifteen patients. Virchows Arch Pathol Anat 1963, 336:238-269.
3. Schneider T, Moos V, Loddenkemper C, Marth T, Fenollar F, Raoult D. Whipple's disease: new aspects of pathogenesis and treatment. Lancet Infect Dis 2008, 8:179-190.
4. Fenollar F, Puéchal X, Raoult D. Whipple's disease. N Eng J Med 2007, 356:55-66.
5. Gubler JG, Kuster M, Dutly F. Whipple endocarditis without overt gastrointestinal disease: report of four cases. Ann Intern Med 1999, 131:112-116.
6. Aïouaz H, Célard M, Puget M. Whipple's disease endocarditis: report of 5 cases and review of the literature. Rev Med Interne 2005, 26:784-790.
7. Fenollar F, Lepidi H, Raoult D. Whipple's endocarditis: review of the literature and comparisons with Q fever, Bartonella infection, and blood culture-positive endocarditis. Clin Infect Dis 2001, 33:1309-1316.
8. Morgenegg S, Dutly F, Altwegg M. Cloning and sequencing of a part of the heat shock protein 65 gene (hsp65) of 'Tropheryma whippelii' and its use for detection of 'T. Whippelii' in clinical specimens by PCR. J Clin Microbiol 2000, 38:2248-2253.
9. Li W, Fenollar F, Rolain JM. Genotyping reveals a wide heterogeneity of Tropheryma whipplei. Microbiology 2008, 154:521-527.
10. Schoedon G, Goldenberger D, Forrer R. Deactivation of macrophages with interleukin-4 is the key to the isolation of Tropheryma whippelii. J Infect Dis 1997, 176:672-677.
11. Hinrikson HP, Dutly F, Nair S, Altwegg M. Detection of three different types of 'Tropheryma whippelii' directly from clinical specimens by sequencing, single-strand conformation polymorphism (SSCP) analysis and type-specific PCR of their 16S-23S ribosomal intergenic spacer region. Int J Syst Bacteriol 1999, 49:1701-1706.
12. Khairy P, Graham AF. Whipple's disease and the heart. Can J Cardiol 1996, 12:831-834.
13. Bonneville B, Vassalli P, Cormier JM, Benhamou JP, Fauvert R. Whipple's disease and multiple arterial emboli. Arch Mal Appar Dig Mal Nutr 1962, 51:731-736.
14. Gross JB, Wollaeger EE, Sauer WG, Huizenga KA, Dahlin DC, Power MH. Whipple's disease; report of four cases, including two in brothers, with observations on pathologic physiology, diagnosis, and treatment. Gastroenterology 1959, 36:65-93.
15. Sieracki JC, Fine G. Whipple's disease; observations on systemic involvement. II. Gross and histologic observations. AMA Arch Pathol 1959, 67:81-93.
16. Wright CB, Hiratzka LF, Crossland S, Isner J, Snow JA. Aortic insufficiency requiring valve replacement in Whipple's disease. Ann Thorac Surg 1978, 25:466-469.
17. Wendler D, Mendoza E, Schleiffer T, Zander M, Maier M. Tropheryma whippelii endocarditis confirmed by polymerase chain reaction. Eur Heart J 1995, 16:424-425.
18. Schilling D, Adamek HE, Kaufmann V, Maier M, Riemann JF. Arthralgia as an early extraintestinal symptom of Whipple's disease. Report of five cases. J Clin Gastroenterol 1997, 24:18-20.
19. Maizel H, Ruffin JM, Dobbins WO. Whipple's disease: a review of 19 patients from one hospital and a review of the literature since 1950. Medicine (Baltimore) 1970, 49:175-205.
20. James TN, Haubrich WS. De subitaneis mortibus. XIV. Bacterial arteritis in Whipple's disease. Circulation 1975, 52:722-731.
21. Lepidi H, Fenollar F, Dumler JS. Cardiac valves in patients with Whipple endocarditis: microbiological, molecular, quantitative histologic, and immunohistochemical studies of 5 patients. J Infect Dis 2004, 190:935-945.
22. La MV, Crapoulet N, Barbry P, Raoult D, Renesto P. Comparative genomic analysis of Tropheryma whipplei strains reveals that diversity among clinical isolates is mainly related to the WiSP proteins. BMC Genomics 2007, 8:349.
23. Houpikian P, Raoult D. Blood culture-negative endocarditis in a reference center: etiologic diagnosis of 348 cases. Medicine (Baltimore) 2005, 84:162-173.
24. Le Scanff J, Gaultier JB, Durand DV. False positive PCR detections of Tropheryma whipplei in diagnostic samples are rare. Rev Med Interne 2008, 29:861-867.
25. Voldstedlund M, Norum Pedersen L, Baandrup U, Klaaborg KE, Fuursted K. Broad-range PCR and sequencing in routine diagnosis of infective endocarditis. APMIS 2008, 116:190-198.
26. Grijalva M, Horvath R, Dendis M, Cerny J, Benedik J. Molecular diagnosis of culture negative infective endocarditis: clinical validation in a group of surgically treated patients. Heart 2003, 89:263-268.
27. Marin M, Munoz P, Sanchez M. Molecular diagnosis of infective endocarditis by real-time broad-range polymerase chain reaction (PCR) and sequencing directly from heart valve tissue. Medicine (Baltimore) 2007, 86:195-202.
28. Bosshard PP, Kronenberg A, Zbinden R, Ruef C, Böttger EC, Altwegg M. Etiologic diagnosis of infective endocarditis by broad-range polymerase chain reaction: a 3-year experience. Clin Infect Dis 2003, 37:167-172.
29. West D, Hutcheon S, Kain R, Reid T, Walton S, Buchan K. Whipple's endocarditis. J R Soc Med 2005, 98:362-364.
30. Williams OM, Nightingale AK, Hartley J. Whipple's disease. N Eng J Med 2007, 356:1479-1480.
31. Smith MA. Whipple endocarditis without gastrointestinal disease. Ann Intern Med 2000, 132:595.
32. Wolfert AL, Wright JE. Whipple's disease presenting as sarcoidosis and valvular heart disease. South Med J 1999, 92:820-825.
33. Richardson DC, Burrows LL, Korithoski B. Tropheryma whippelii as a cause of afebrile culture-negative endocarditis: the evolving spectrum of Whipple's disease. J Infect 2003, 47:170-173.
34. Dreier J, Szabados F, von Herbay A, Kröger T, Kleesiek K. Tropheryma whipplei infection of an acellular porcine heart valve bioprosthesis in a patient who did not have intestinal Whipple's disease. J Clin Microbiol 2004, 42:4487-4493.
35. Geissdörfer W, Wittmann I, Seitz G. A case of aortic valve disease associated with Tropheryma whippelii infection in the absence of other signs of Whipple's disease. Infection 2001, 29:44-47.
36. Geissdörfer W, Wittmann I, Röllinghoff M, Schoerner C, Bogdan C. Detection of a new 16S-23S rRNA spacer sequence variant (type 7) of Tropheryma whippelii in a patient with prosthetic aortic valve endocarditis. Eur J Clin Microbiol Infect Dis 2001, 20:762-763.
37. Kolek M, Zaloudikova B, Freiberger T, Brat R. Aortic and mitral valve infective endocarditis caused by Tropheryma whipplei and with no gastrointestinal manifestations of Whipple's disease. Klin Mikrobiol Infekc Lek 2007, 13:213-216.
38. Ferrari M de L, Vilela EG, Faria LC. Whipple's disease. Report of five cases with different clinical features. Rev Inst Med Trop Sao Paulo 2001, 43:45-50.
39. Saba M, Rollot F, Park S. Whipple disease, initially diagnosed as sarcoidosis. Presse Med 2005, 34:1521-1524.
40. Pron B, Poyart C, Abachin E. Diagnosis and follow-up of Whipple's disease by amplification of the 16S rRNA gene of Tropheryma whippelii. Eur J Clin Microbiol Infect Dis 1999, 18:62-65.
41. Charniot JC, Mouthon L, Martin A. Valvular locations in Whipple's disease: report of two cases and review of the literature. Arch Mal Coeur Vaiss 2001, 94:1117-1121.
42. Marrakchi C, Abdennadher M, Blin D. Endocarditis caused by Tropheryma whippelii. Tunis Med 2004, 82:781-784.
43. Hansen A, Mereles D. Cardiac complications in Whipple's disease. Eur J Echocardiogr 2008, 9:426-427.
44. Moreillon P, Que YA. Infective endocarditis. Lancet 2004, 363:139-149.
45. Li JS, Sexton DJ, Mick N. Proposed modifications to the Duke criteria for the diagnosis of infective endocarditis. Clin Infect Dis 2000, 30:633-638.
46. Raoult D, Birg ML, La Scola B. Cultivation of the bacillus of Whipple's disease. N Eng J Med 2000, 342:620-625.
47. Fredricks DN, Relman DA. Localization of Tropheryma whippelii rRNA in tissues from patients with Whipple's disease. J Infect Dis 2001, 183:1229-1237.
48. Durack DT, Lukes AS, Bright DK. New criteria for diagnosis of infective endocarditis: utilization of specific echocardiographic findings. Duke endocarditis service. Am J Med 1994, 96:200-209.
49. Durand DV, Lecomte C, Cathebras P, Rousset H, Godeau P. Whipple disease. Clinical review of 52 cases. The SNFMI research group on Whipple disease. Société nationale française de médecine interne. Medicine (Baltimore) 1997, 76:170-184.
50. Fenollar F, Rolain JM, Alric L. Resistance to trimethoprim/sulfamethoxazole and Tropheryma whipplei. Int J Antimicrob Agents 2009, 34:255-259.
51. Breitkopf C, Hammel D, Scheld HH, Peters G, Becker K. Impact of a molecular approach to improve the microbiological diagnosis of infective heart valve endocarditis. Circulation 2005, 111:1415-1421.
52. Lang S, Watkin RW, Lambert PA, Bonser RS, Littler WA, Elliott TS. Evaluation of PCR in the molecular diagnosis of endocarditis. J Infect 2004, 48:269-275.
53. Marin M, Munoz P, Sanchez M. Tropheryma whipplei infective endocarditis as the only manifestation of Whipple's disease. J Clin Microbiol 2007, 45:2078-2081.
54. Célard M, de Gevigney G, Mosnier S. Polymerase chain reaction analysis for diagnosis of Tropheryma whipplei infective endocarditis in two patients with no previous evidence of Whipple's disease. Clin Infect Dis 1999, 29:1348-1349.