HLA-G polymorphism patterns show lack of detectable association with recurrent spontaneous abortion

Tissue Antigens

Volumn 76, Issue 3, 2010, Pages 216-222

  Aruna, M ^a   Sudheer, P S ^a   Andal, S ^b   Tarakeswari, S ^c   Reddy, A G ^d   Thangaraj, K ^d   Singh, L ^d   Reddy, B M ^a  

^a INDIAN STATISTICAL INSTITUTE   (India)

^b Lakshmi Fertility Clinic and Research Centre   (India)

^c Fernandez Hospital   (India)

^d CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

association; human leukocyte antigen sharing; human leukocyte antigen G alleles; Indian population; recurrent spontaneous abortion

Indexed keywords

HLA G ANTIGEN;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RECURRENT ABORTION; SPONTANEOUS ABORTION;

ABORTION, HABITUAL; ABORTION, SPONTANEOUS; ADOLESCENT; ADULT; ALLELES; CASE-CONTROL STUDIES; DNA; FEMALE; GENE FREQUENCY; HISTOCOMPATIBILITY ANTIGENS CLASS I; HLA ANTIGENS; HUMANS; MALE; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; PREGNANCY; YOUNG ADULT;

EID: 77955165493     PISSN: 00012815     EISSN: 13990039     Source Type: Journal    
DOI: 10.1111/j.1399-0039.2010.01505.x     Document Type: Article

References (34)

1. Morales PJ, Pace JL, Platt JS et al. Placental cell expression of HLA-G2 isoforms is limited to the invasive trophoblast phenotype. J Immunol 2003 : 171 : 6215 6224.
2. Ishitani A, Geraghty DE. Alternative splicing of HLA-G transcripts yields proteins with primary structures resembling both class I and class II antigens. Proc Natl Acad Sci U S A 1992 : 89 : 3947 3951.
3. Fujii T, Ishitani A, Geraghty DE. A soluble form of the HLA-G antigen is encoded by a messenger ribonucleic acid containing intron 4. J Immunol 1994 : 153 : 5516 5524.
4. Hunt JS, Orr HT. HLA and maternal-foetal recognition. FASEB J. 1992 : 6 : 2344 2348.
5. LeBouteiller P, Legrand-Abravanel F, Solier C. Soluble HLA-G1 at the materno-foetal interface-a review. Placenta 2003 : 24 : S10 5.
6. LeMaoult J, LeDiscorde M, Rouas-Freiss N et al. Biology and functions of human leukocyte antigen-G in health and sickness. Tissue Antigens 2003 : 62 : 273 284.
7. Hunt JS, Petroff MG, McIntire RH, Ober C. HLA-G and immune tolerance in pregnancy. FASEB J 2005 : 19 : 681 693.
8. Carosella ED, Dausset J, Rouas-Freiss N. Immunotolerant functions of HLA-G. Cell Mol Life Sci 1999 : 55 : 327 333.
9. Ishitani A, Sageshima N, Lee N et al. Protein expression and peptide binding suggest unique and interacting functional roles for HLA-E, F, and G in maternal placental immune recognition. J Immunol 2003 : 171 : 1376 1384.
10. LeMaoult J, Krawice-Radanne I, Dausset J, Carosella ED. HLA-G1- expressing antigen-presenting cells induce immunosuppressive CD4+ T cells. Proc Natl Acad Sci U S A 2004 : 101 : 7064 7069.
11. Beer AE. Function of HLA antigens. http://repro-med.net/repro-med-site2/ index.php?option=com-content&view=article&id=54:function-of-hla- antigens&catid=11:about-the-program&Itemid=71
12. Karhukorpi J, Laitinen T, Tiilikainen AS. HLA-G polymorphism in Finish couples with recurrent spontaneous miscarriage. Br J Obstet Gynaecol 1997 : 104 : 1212 1214.
13. Hviid TV, Hylenius S, Hoegh AM, Kruse C, Christiansen OB. HLA-G polymorphisms in couples with recurrent spontaneous abortions. Tissue Antigens 2002 : 60 : 122 132.
14. Ober C, Aldrich CL, Chervoneva I et al. Variation in the HLA-G promoter region influences miscarriage rates. Am J Hum Genet 2003 : 72 : 1425 1435.
15. Pfeiffer KA, Fimmers R, Engels G, Van-der-Ven H. The HLA-G is potentially associated with idiopathic recurrent spontaneous abortions. Mol Hum Reprod 2001 : 7 : 373 378.
16. Aldrich CL, Stephenson MD, Karrison T et al. HLA-G genotypes and pregnancy outcome in couples with unexplained recurrent miscarriage. Mol Hum Genet 2001 : 7 : 1167 1172.
17. Moreau P, Contu L, Alba F et al. HLA-G gene polymorphism in human placentas: possible association of G*0106 allele with preeclampsia and miscarriage. Biol Reprod 2008 : 79 : 459 467.
18. Hviid TV, Hylenius S, Lindhard A, Christiansen OB. Association between human leukocyte antigen-G genotype and success of in vitro fertilization and pregnancy outcome. Tissue Antigens 2004 : 64 : 66 9.
19. Yamashita T, Fujii T, Tokunaga K et al. Analysis of human leukocyte antigen-G including intron 4 in Japanese couples with habitual abortion. Am J Reprod Immunol 1999 : 41 : 159 163.
20. Penzes M, Rajczy K, Gyodi E, Reti M, Feher E, Petranyi G. HLA-G gene polymorphism in the normal population and in recurrent spontaneous abortion in Hungary. Transplant Proc 1999 : 31 : 1832 1833.
21. Yan WH, Fan LA, Yang JQ, Xu LD, Ge Y, Yao FJ. HLA-G polymorphism in a Chinese Han population with recurrent spontaneous abortion. Int J Immunogenet 2006 : 33 : 55 8.
22. Sipak-Szmigiel O, Cybulski C, Lubinski J, Ronin-Walknowska E. HLA-G polymorphism in a Polish population and reproductive failure. Tissue Antigens 2007 : 71 : 67 71.
23. Emmer PM, Steegers EA, Kerstens HM et al. Altered phenotype of HLA-G expressing trophoblast and decidual natural killer cells in pathological pregnancies. Hum Reprod 2002 : 17 : 1072 1080.
24. Patel RN, Quack KC, Hill JA, Schust DJ. Expression of membrane bound HLA-G at the maternal-foetal interface is not associated with pregnancy maintenance among patients with idiopathic recurrent pregnancy loss. Mol Hum Reprod 2003 : 9 : 551 557.
25. Bhalla A, Stone PR, Liddell HS, Zanderigo A, Chamley LW. Comparison of the expression of human leukocyte antigen (HLA)-G and HLA-E in women with normal pregnancy and those with recurrent miscarriage. Reprod 2006 : 131 : 583 589.
26. Abbas A, Tripathi P, Naik S, Agrawal S. Analysis of human leukocyte antigen (HLA)-G polymorphism in normal women and in women with recurrent spontaneous abortions. Eur J Immunogenet 2004 : 31 : 275 278.
27. Tripathi P, Abbas A, Naik S, Agrawal S. Role of 14-bp deletion in the HLA-G gene in the maintenance of pregnancy. Tissue Antigens 2004 : 64 : 706 710.
28. Abbas A, Javed S, Agarwal S. Transcriptional status of HLA-G at the maternal-fetal interface in recurrent spontaneous abortion. Int J Gynecol Obstet 2006 : 93 : 148 149.
29. Suryanarayana V, Rao L, Kanakavalli M et al. Association between novel HLA-G genotypes and risk of recurrent miscarriages: a case-control study in a south population. Reprod Sci 2008 : 15 : 817 824.
30. Reddy BM, Naidu VM, Madhavi VK et al. Microsatellite diversity in Andhra Pradesh, India: genetic stratification versus social stratification. Hum Biol 2005 : 77 : 803 823.
31. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor, New York : Cold Spring Harbor Laboratory Press, 1989.
32. Thangaraj K, Singh L, Reddy AG et al. Genetic affinities of the Andaman Islanders, a vanishing human population. Curr Biol 2003 : 13 : 86 93.
33. Hviid TV. HLA-G in human reproduction: aspects of genetics, function and pregnancy complications. Hum Reprod Update 2006 : 12 : 209 232.
34. Matte C, Lacaille J, Zijenah L, Ward B, the ZVITAMBO Study Group, Roger M. HLA-G exhibits low level of polymorphism in indigenous East Africans. Hum Immunol 2002 : 63 : 495 501.