Incidental findings are frequent in young healthy individuals undergoing magnetic resonance imaging in brain research imaging studies: A prospective single-center study

Journal of Computer Assisted Tomography

Volumn 34, Issue 4, 2010, Pages 596-600

  Hartwigsen, Gesa ^a   Siebner, Hartwig R ^a,b   Deuschl, Günther ^a   Jansen, Olav ^c   Ulmer, Stephan ^c  

^a UNIVERSITY OF KIEL   (Germany)

^b HVIDOVRE HOSPITAL   (Denmark)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

healthy subjects; incidental findings; informed written consent; magnetic resonance imaging (MRI); prospective

Indexed keywords

BRAIN MAPPING; DIAGNOSIS; MAGNETISM; RESONANCE;

BRAIN RESEARCH; HEALTHY INDIVIDUALS; HEALTHY SUBJECTS; HEALTHY VOLUNTEERS; INCIDENTAL FINDINGS; INFORMED WRITTEN CONSENT; MAGNETIC RESONANCE IMAGING; PROSPECTIVES; RESEARCH-DRIVEN; WHOLE BRAINS;

MAGNETIC RESONANCE IMAGING;

ADOLESCENT; ADULT; AGED; ARTERIOVENOUS MALFORMATION; ARTICLE; BRAIN; CAVERNOUS HEMANGIOMA; CHILD; FEMALE; HUMAN; HYPOPHYSIS DISEASE; MAJOR CLINICAL STUDY; MALE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SCHOOL CHILD;

EID: 77955146573     PISSN: 03638715     EISSN: None     Source Type: Journal    
DOI: 10.1097/RCT.0b013e3181d9c2bb     Document Type: Article

References (25)

1. Illes J, Kirschen MP, Edwards E, et al. Ethics. Incidental findings in brain imaging research. Science. 2006;311:783-784. (Pubitemid 43228825)
2. Brown DA, Hasso AN. Toward a uniform policy for handling incidental findings in neuroimaging research. AJNR Am JNeuroradiol. 2008;29:1425-1427.
3. Weber F, Knopf H. Incidental findings in magnetic resonance imaging of the brains of healthy young men. J Neurol Sci. 2006;240:81-84.
4. Katzman GL, Dagher AP, Patronas NJ. Incidental findings on brain magnetic resonance imaging from 1000 asymptomatic volunteers. JAMA. 1999;282:36-39.
5. Vernooij MW, Ikram MA, Tanghe HL, et al. Incidental findings on brain MRI in the general population. N Engl J Med. 2007;357: 1821-1828.
6. Illes J, Chin VN. Bridging philosophical and practical implications of incidental findings in brain research. J Law Med Ethics. 2008;36: 298-304, 212.
7. Alphs HH, Schwartz BS, Stewart WF, et al. Findings on brain MRI from research studies of occupational exposure to known neurotoxicants. AJR Am JRoentgenol. 2006;187:1043-1047.
8. Gupta SN, Belay B. Intracranial incidental findings on brain MR images in a pediatric neurology practice: a retrospective study. J Neurol Sci. 2008; 264: 34-37
9. Morris Z, Whiteley WN, Longstreth WT, Jr, et al. Incidental findings on brain magnetic resonance imaging: systematic review and meta-analysis. BMJ. 2009;339:b3016.
10. Yue NC, Longstreth WT, Jr, Elster AD, et al. Clinically serious abnormalities found incidentally at MR imaging of the brain: data from the Cardiovascular Health Study. Radiology. 1997;202:41-46.
11. Onizuka M, Suyama K, Shibayama A, et al. Asymptomatic brain tumor detected at brain check-up. Neurol Med Chir (Tokyo). 2001;41: 431-434; discussion 435.
12. Tsushima Y, Taketomi-Takahashi A, Endo K. Prevalence of abnormal findings on brain magnetic resonance (MR) examinations in adult participants of brain docking. BMC Neurol. 2005;5:18.
13. Baumgart D, Egelhof T. Preventive whole-body screening encompassing modern imaging using magnetic resonance tomography [in German]. Herz. 2007;32:387-394.
14. Lee WJ, Chang LB, Lee YC. Incidental findings on brain MRI.N Engl J Med. 2008;358:853-854; author reply 854-855.
15. Illes J. Brain screening and incidental findings: flocking to folly? Lancet Neurol. 2008;7:23-24. (Pubitemid 350251929)
16. Okuda DT, Mowry EM, Beheshtian A, et al. Incidental MRI anomalies suggestive of multiple sclerosis: the radiologically isolated syndrome. Neurology. 2009;72:800-805.
17. Ulmer S, Engellandt K, Stiller U, et al. Chronic subdural hemorrhage into a giant arachnoidal cyst (Galassi classification type III). J Comput Assist Tomogr. 2002;26:647-653.
18. Kim BS, Illes J, Kaplan RT, et al. Incidental findings on pediatric MR images of the brain. AJNR Am J Neuroradiol. 2002;23: 1674-1677.
19. Milstein AC. Research malpractice and the issue of incidental findings. J Law Med Ethics. 2008;36:356-360, 214.
20. Illes J, Kirschen MP, Edwards E, et al. Practical approaches to incidental findings in brain imaging research. Neurology. 2008;70: 384-390.
21. Ulmer S, Jensen UR, Jansen O, et al. Impact of incidental findings on neuroimaging research using functional MR imaging. AJNR Am J Neuroradiol. 2009;30:E55.
22. Illes J, Kirschen MP, Karetsky K, et al. Discovery and disclosure of incidental findings in neuroimaging research. J Magn Reson Imaging. 2004;20:743-747. (Pubitemid 39426067)
23. Illes J, Rosen AC, Huang L, et al. Ethical consideration of incidental findings on adult brain MRI in research. Neurology. 2004;62:888-890.
24. Hernesniemi JA, Dashti R, Juvela S, et al. Natural history of brain arteriovenous malformations: a long-term follow-up study of risk of hemorrhage in 238 patients. Neurosurgery. 2008;63:823-829; discussion 829-831.
25. Kirschen MP, Jaworska A, Illes J. Subjects' expectations in neuroimaging research. J Magn Reson Imaging. 2006;23: 205-209.