Synthesis of E27-5 class nucleoside analogue by isotope exchange technique

Journal of Labelled Compounds and Radiopharmaceuticals

Volumn 53, Issue 5-6, 2010, Pages 461-463

  Postolache, C ^a   Tanase, C ^b   Matei, Lidia ^a   Bubueanu, G ^a  

^a HORIA HULUBEI NATIONAL INSTITUTE OF PHYSICS AND NUCLEAR ENGINEERING   (Romania)

^b NATIONAL INSTITUTE FOR CHEMICAL PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (Romania)

Author keywords

Antitumor; Antiviral; Labelled compounds; Nucleoside analogues; Tritium

Indexed keywords

BIOACTIVITY; DRUG PRODUCTS; ISOTOPES;

ANTI-TUMORS; ANTITUMOUR ACTIVITY; ANTIVIRAL ACTIVITIES; ANTIVIRALS; CROSS RESISTANCE; ISOTOPE EXCHANGE TECHNIQUE; LABELED COMPOUND; LABELINGS; NUCLEOSIDE ANALOGS; SUGAR MOIETY;

BIOMOLECULES;

1 (5 CLORO 7 HYDROXYMETHYLBICYCLO[2.2.1]HEPT 2 YL) 5 FLUORO 1H PIRIMIDINE 2,4 DIONE; 11 (5 CHLORO 7 HYDROXYMETHYL BICYCLO[2.2.1]HEPT 2 YL) 5 METYL 1H PIRIMIDINE,2,4 DIONE; E 27 5 FU; E 27 5 T; NUCLEOSIDE ANALOG; PHOSPHATE BUFFERED SALINE; UNCLASSIFIED DRUG;

CATALYSIS; CONFERENCE PAPER; DRUG SYNTHESIS; EVAPORATION; HYDROLYSIS; ISOTOPE LABELING; THIN LAYER CHROMATOGRAPHY;

EID: 77955137119     PISSN: 03624803     EISSN: 10991344     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (6)

1. th Annual Congress of International Drug Discovery Science and Technology, 18-22-Oct. 2008, Beijing, China, 473.
2. O Mitsunobu, Synthesis, 1981, 1981:pp 1-28 DOI: 10.1055/s-1981-29317.
3. D. L Huges, Org. Prep. Proced. Int. 1996, 28, 127-164.
4. H. Vorbruggen, K. Krolikiewicz, B. Bennua, Chemische. Berichte. 1981, 114, 1234-1255.
5. C. Postolache, C. Tanase, L. Matei, V. Serban, J. of Label. Compd and Radiopharm. 2007, 50, 5-6, 442-443.
6. L. Matei, C. Postolache, G Bubueanu, Fus. Sci. and Technol., 2008, 54, 2, 643-646.