ADHD and its comorbidity: An example of gene-environment interaction and its implications for child and family social work

Child and Family Social Work

Volumn 15, Issue 3, 2010, Pages 265-275

  Howe, David ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

Author keywords

ADHD; Comorbidity; Environment; Genes; Social work

Indexed keywords

EID: 77955135728     PISSN: 13567500     EISSN: 13652206     Source Type: Journal    
DOI: 10.1111/j.1365-2206.2009.00666.x     Document Type: Article

References (69)

1. Practice parameters for the assessment and treatment of children, adolescents, and adults with attention deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry 1997, 36:85S-121S. American Academy of Child and Adolescent Psychiatry Official Action, Suppl.
2. Ainsworth M, Blehar M, Waters E, Wall S. Patterns of Attachment: Psychological Study of the Strange Situation 1978, Erlbaum, Hillsdale, NJ
3. Diagnostic and Statistical Manual of Mental Disorder 1987, American Psychiatric Association, 3rd, edn., American Psychiatric Association, Washington, DC
4. Diagnostic and Statistical Manual of Mental Disorder 2000, American Psychiatric Association, 4th, edn., American Psychiatric Association, Washington, DC
5. Anastopoulos AE, Shelton TL, DuPaul GJ, Guevremont DC. Parent training for attention-deficit hyperactivity disorder: its impact on parent functioning. Journal of Abnormal Child Psychology 1993, 21:581-596.
6. Banerjee TD, Middleton F, Faraone SV. Environmental risk factors for attention-deficit hyperactivity disorder. Acta Paediatrica 2007, 96:1269-1274.
7. Barkely R. Attention-Deficit Hyperactivity Disorder: A Handbook for Diagnosis and Treatment 1998, Guilford Press, New York
8. Barkely R, Cunningham CE. The effects of methylphenidate on the mother-child interactions of hyperactive children. Archives of General Psychiatry 1979, 36:201-211.
9. Barkely R, Anastopoulos AD, Guevremond DC, Fletcher KE. Adolescents with ADHD: mother-adolescent interactions, family beliefs and conflicts, and maternal psychopathology. Journal of Abnormal Child Psychology 1992, 20:263-288.
10. Bentall R. Doctoring the Mind: Why Psychiatric Treatments Fail 2009, Allen Lane, London
11. Berlin L, Ziv Y, Amaya-Jackson L, Greenberg MT. Enhancing Early Attachments: Theory, Research, Interventions and Policy 2005, eds, Guilford Press, New York
12. Bhutta AT, Cleves MA, Casey PH. Cognitive and behavioral outcomes of school-aged children who were born pre-term: a meta-analysis. Journal of the American Medical Association 2002, 288:728-737.
13. Biederman J, Faraone S, Mick E, Spencer T, Wilens T, Kiely K. High risk for attention deficit hyperactivity disorder among children of parents with childhood onset of the disorder: a pilot study. American Journal of Psychiatry 1995, 152:431-435.
14. Breggin PR. Brain Disabling Treatments in Psychiatry 2008, Springer, New York
15. Carlson EA, Jacobvitz D, Sroufe LA. A developmental investigation of inattentiveness and hyperactivity. Child Development 1995, 66:37-54.
16. Clarke L, Ungerer J, Chahoud K, Johnson S, Stiefel I. Attention deficit hyperactivity disorder is associated with attachment insecurity. Clinical Child Psychology and Psychiatry 2002, 7:179-198.
17. Colvert E, Rutter M, Kreppner J, Beckett C, Castle J, Groothues C. Do theory of mind and executive function deficits underlie the adverse outcomes associated with profound early deprivation? Findings from the English and Romanian Adoptees Study. Journal of Abnormal Psychology 2008, 36:1957-1068.
18. Connors CK, Epstein JN, March JS, Angold A, Wells KC, Klaric J. Multimodal treatment of ADHD in the MTA: an alternative outcome analysis. Journal of the American Academy of Child and Adolescent Psychiatry 2001, 40:159-167.
19. Crittenden PM. Raising Parents: Attachment, Parenting and Child Safety 2008, Willan, Cullompton
20. Crittenden PM, Barne GRK. Familial contributions to ADHD: an attachment perspective. Tidsskrift for Norsk Psykologforening 2007, 44:1220-1229. http://www.psykologtidsskriftet.no/index.php?seks_id=31533&a=2&sok=2, Translation: Available at: (accessed 6 February 2009
21. Fabiano GA, Pelham WE, Gnangy EM, Coles EK, Wheeler-Cox T. A Meta-analysis of Behavioral and Combined Treatments for ADHD 2000, American Psychological Association, Washington, DC
22. Finzi-Dottan R, Manor I, Tyano S. ADHD, temperament, and parental style as predictors of the child's attachment patterns. Child Psychiatry and Human Development 2006, 37:103-114.
23. Fonagy P, Target M, Cottrell D, Phillips J, Kurtz Z. What Works for Whom: A Critical Review of Treatments for Children and Adolescents 2002, Guilford Press, New York
24. Foreman DM, Foreman D, Minty EB. The association between hyperkinesis and breakdown of parenting in clinic populations. Archives of Disease in Childhood 2005, 90:245-248.
25. Garbarino J, Thompson B. Child attachment and family environment differences of adolescent children with ADHD and/or conduct disorder. 2000, Paper presented at the Annual Meeting of the Southwest Educational Research Association, Dallas, Texas. 27 January 2000
26. Haber JS. ADHD: The Great Misdiagnosis 2003, First Taylor Trade Publishing, Lanham
27. Halasz G, Vance ALA. Attention deficit hyperactivity disorder in children: moving forward with divergent perspectives. The Medical Journal of Australia 2002, 177:554-557.
28. Johnson C, Mash EJ. Families of children with attention-deficit/hyperactivity disorder: review and recommendations for future research. Clinical Child and Adolescent Psychology Newslettter 2001, 4:183-208.
29. Juffer F, Bakersman-Kranenberg J, van IJzendoorn M. Promoting Positive Parenting: An Attachment-Based Intervention 2008, Psychology Press, New York
30. Kreppner JM, O'Connor TG, Rutter M, Beckett C, Castle J, Croft C. Can inattention/overactivity be an institutional deprivation syndrome? Journal of Abnormal Child Psychology 2001, 29:513-528.
31. Ladnier RD, Massanrani AE. Treating ADHD as attention deficit hyperactivity disorder. Handbook of Attachment Interventions 2000, 27-65. Levy TM, ed., Academic Press, San Diego, CA
32. Lakatos K, Toth I, Nemoda Z, Ney K, Sasvari Szekely M, Gervai J. Dopamine D4 receptor (DRD4) gene polymorphism is associated with attachment disorganisation in infants. Molecular Psychiatry 2000, 5:633-637.
33. Langley K, Rice F, van den Bree MB. Maternal smoking during pregnancy as an environmental risk factor for attention deficit hyperactivity disorder behaviour: a review. Minerva Pediatrica 2005, 57:359-371.
34. Levy F, McStephen M, Hay DA. The diagnostic genetics of ADHD symptoms and subtypes. Attention, Genes, and ADHD 2001, 35-57. Levy F, Hay DA, eds, Taylorand Francis, Philadelphia, PA
35. Lieberman A, Van Horn P. Psychotherapy with Infants and Young Children: Repairing the Effects of Stress and Trauma on Early Attachments 2008, Guilford Press, New York
36. Lifford KJ, Harold GT, Thapar A. Parent-child relationships and ADHD symptoms: a longitudinal analysis. Journal of Abnormal Child Psycholology 2008, 36:285-296.
37. McNeil T. Evidence-based practice in an age of relativism: toward a model for practice. Social Work 2006, 51:147-156.
38. Manuzza S, Klein RG. Long-term prognosis in attention-defecit/hyperactivity disorder. Child and Adolescent Psychiatric Clinics of North America 2000, 9:711-726.
39. March JS. The future of psychotherapy for mentally ill children and adolescents. The Journal of Child Psychology and Psychiatry 2009, 50:170-179.
40. Mill J, Petronis A. Pre- and perinatal environmental risks for attention-deficit hyperactivity disorder (ADHD): the potential role of epigenetic processes in mediating susceptibility. The Journal of Child Psychology and Psychiatry 2008, 49:1020-1030.
41. Moncrieff J. The Myth of the Chemical Cure 2009, Palgrave Macmillan, Basingstoke
42. Nigg JT, Hinshaw SP, Huang-Pollock C. Disorders of attention and impulse regulation. Developmental Psychopathology, Volume Three 2006, 358-403. Cicchetti D, Cohen DJ, 2nd, edn (eds, John Wiley, New York
43. Noble D. The Music of Life: Biology Beyond the Genome 2006, Oxford University Press, Oxford
44. Olds DL, Kitzman H, Cole R, Robinson J, Sidora K, Luckey D. Effects of nurse home visiting on maternal life-course and child development: age-six follow up of a randomized trial. Pediatrics 2004, 114:1550-1559.
45. Olfson M, Gameroff MJ, Marcus SC, Jensen PS. National trends in the treatment of attention deficit hyperactivity disorder. American Journal of Psychiatry 2003, 160:1077-1078.
46. Oppenheim D, Goldsmith DF. Attachment Theory in Clinical Work with Children 2007, Guilford Press, New York
47. Pelham WE. The NIMH multimodal treatment study for attention deficit hyperactivity disorder: just say yes to drugs alone? Canadian Journal of Psychiatry 1999, 44:981-990.
48. Pelham WE, Wheeler T, Chronis AM. Empirically supported psychosocial treatment for attention deficit hyperactivity disorder. Journal of Clinical Psychology 1998, 27:190-205.
49. Pentecost D, Wood N. Knowledge and perceptions of child-care social workers about ADHD. British Journal of Social Work 2002, 32:931-943.
50. Perry B, Szalavits M. The Boy Who was Raised as a Dog 2006, Basic Books, New York
51. Polanczyk G, Silva de Lima M, Horta BL, Biederman J, Rohde LA. The worldwide prevalence of ADHD: a systematic review and metaregression analysis. American Journal of Psychiatry 2007, 164:942-948.
52. dosReis S, Owens PL, Puccia KB, Leaf PJ. Multimodal treatment for ADHD among youths in three Medicaid subgroups: disabled, foster care, and low income. Psychiatric Services 2004, 55:1041-1048.
53. Rhee SH, Willcutt EG, Hartman CA, Pennington BF, DeFries JC. Test of alternative hypotheses explaining the comorbidity between attention-deficit/hyperactivity disorder and conduct disorder. Journal of Abnormal Child Psychology 2008, 36:29-40.
54. Schore A. The experience-dependent maturation of a regulatory system in the orbital prefrontal cortex and the origin of developmental psychopathology. Development and Psychopathology 1996, 8:59-87.
55. Schore A. Effects of a secure attachment relationship on right brain development, affect regulation, and infant mental health. Infant Mental Health Journal 2001a, 22:7-66.
56. Schore A. The effects of early relational trauma on right brain development, affect regulation, and infant mental health. Infant Mental Health Journal 2001b, 22:201-269.
57. Simmel C, Brooks D, Barth R. Externalizing symptomatology among adoptive youth: prevalence and preadoption risk factors. Journal of Abnormal Child Psychology 2001, 29:57-69.
58. Slade A, Sadler LS, Mayes LC. Minding the baby: enhancing parental reflection functioning in a nursing/mental health home visiting program. Enhancing Early Attachments: Theory, Research, Intervention and Policy 2005, 152-177. Berlin L, Ziv Y, Amaya-Jackson LGreenberg M. eds, Guilford, New York
59. Stevens SE, Sonuga-Barke EJS, Kreppner JM, Beckett C, Castle J, Colvert E. Inattention/overactivity following early severe institutional deprivation: presentation and associations in early adolescence. Journal of Abnormal Child Psychology 2008, 36:385-398.
60. Sunderland M. The Science of Parenting 2006, DK Books, London
61. Tannock R, Schachar R. Executive dysfunction as an underlying mechanism of behavior and language problems in attention deficit hyperactivity disorder. Language, Learning and Behavior Disorders 1996, 128-155. Beitchman JH, Cohen NJKonstantareas MMTannock R. eds, Cambridge University Press, Cambridge
62. Taylor E. Developing ADHD. The Journal of Child Psychology and Psychiatry 2009, 50:126-132.
63. Taylor E, Overmeyer S. Principles of treatment for Hyperkinetic Disorder: practice approaches for the UK. Journal of Child Psychology and Psychiatry 1999, 40(8):1147-1157.
64. Thapar A, O'Donovan M, Owen MJ. Refining the attention deficit hyperactivity disorder phenotype for molecular genetic studies. Molecular Psychiatry 2006, 11:714-720.
65. Thapar A, Asherton P, Gill M. Gene-environment interplay in attention-deficit hyperactivity disorder and the importance of a developmental perspective. British Journal of Psychiatry 2007, 190:1-3.
66. Tuvblad C, Zheng M, Raine A. A common genetic factor explains the covariation among ADHD ODD and CD symptoms in 9-10 year old boys and girls. Journal of Abnormal Psychology 2009, 37:153-167.
67. Tyrer P. 2009, Rewriting the Psychiatrist's Bible. BBC Radio 4, broadcast 20.00, 4 August 2009
68. Waschbusch DA, Andrade BF, King S. Attention-deficit hyperactivity disorder. Child and Adolescent Psychopathology: Theoretical and Clinical Implications 2006, 52-77. Essau CA, ed., Routledge, London
69. The ICD-10 Classification of Mental and Behavioral Disorders: Clinical Descriptions and Diagnostic Guidance 1992, World Health Organization, World Health Organisation, Geneva