Clinical trial: 2-L polyethylene glycol-based lavage solutions for colonoscopy preparation - A randomized, single-blind study of two formulations

Alimentary Pharmacology and Therapeutics

Volumn 32, Issue 5, 2010, Pages 637-644

  Cohen, L B ^a   Sanyal, S M ^a   Von Althann, C ^a   Bodian, C ^a   Whitson, M ^a   Bamji, N ^a   Miller, K M ^a   Mavronicolas, W ^a   Burd, S ^a   Freedman, J ^a   Aisenberg, J ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; BISACODYL; MACROGOL;

ABDOMINAL CRAMP; ABDOMINAL PAIN; ADULT; AGED; ARTICLE; BLOATING; CLINICAL TRIAL; COLONOSCOPY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG FORMULATION; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HUMAN; LAVAGE; MAJOR CLINICAL STUDY; MALE; NAUSEA; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; VOMITING;

ADULT; AGED; CATHARTICS; COLONOSCOPY; DOSAGE FORMS; FEMALE; HUMANS; MALE; MIDDLE AGED; POLYETHYLENE GLYCOLS; SINGLE-BLIND METHOD; SOLUTIONS; STATISTICS AS TOPIC; THERAPEUTIC IRRIGATION;

EID: 77955134945     PISSN: 02692813     EISSN: 13652036     Source Type: Journal    
DOI: 10.1111/j.1365-2036.2010.04390.x     Document Type: Article

References (17)

1. Davis GR, Santa Ana CA, Morawski SG, Fordtran JS. Development of a lavage solution associated with minimal water and electrolyte absorption or secretion. Gastroenterology 1980 78 : 991 995.
2. DiPalma JA, Brady CE. Colon cleansing for diagnostic and surgical procedures: polyethylene glycol-electrolyte lavage solution. Am J Gastroenterol 1989 84 : 1008 1016.
3. Adams WJ, Meagher AP, Lubowski DZ, King DW. Bisacodyl reduces the volume of PEG solution required for bowel preparation. Dis Colon Rectum 1994 37 : 229 233.
4. Sharma VK, Chockalingham SK, Ugheoke EA, Kapur A, Ling PH, Howden CW. Prospective, randomized, controlled comparison of the use of polyethylene glycol electrolyte lavage solution in four-liter versus two-liter volumes and pretreatment with either magnesium citrate or bisacodyl for colonoscopy preparation. Gastrointest Endosc 1998 47 : 167 171.
5. Ell C, Fischbach W, Bronisch HJ, et al. Randomized trial of low-volume PEG solution versus standard PEG + electrolytes for bowel cleansing before colonoscopy. Am J Gastroenterol 2008 103 : 883 893.
6. Shawski S, Wexner SD. Oral colorectal cleansing preparations in adults. Drugs 2008 68 : 417 437.
7. Aronchick CA, Lipshutz WH, Wright SH, DuFrayne F, Bergman G. Validation of an instrument to assess colon cleansing. Am J Gastroenterol 1999 94 : 2667.
8. Johanson JF, Popp JW Jr., Cohen LB, et al. A randomized, multicenter study comparing the safety and efficacy of sodium phosphate tablets with 2L polyethylene glycol solution plus bisacodyl tablets for colon cleansing. Am J Gastroenterol 2007 102 : 2238 2246.
9. Patel V, Nicar M, Emmett M, et al. Intestinal and renal effects of low-volume phosphate and sulfate cathartic solutions designed for cleansing the colon: pathophysiological studies in five normal subjects. Am J Gastroenterol 2009 104 : 953 965.
10. Chiu HM, Lin JT, Wang HP, Lee YC, Wu MS. The impact of colon preparation timing on colonoscopic detection of colorectal neoplasms - a prospective endoscopist-blinded randomized trial. Am J Gastroenterol 2006 101 : 2719 2725.
11. Thomas-Gibson S, Rogers P, Cooper S, et al. Judgement of the quality of bowel preparation at screening flexible sigmoidoscopy is associated with variability in adenoma detection rates. Endoscopy 2006 38 : 456 460.
12. Harewood GC, Sharma VK, De Garmo P. Impact of colonoscopy preparation quality on detection of suspected colonic neoplasia. Gastrointest Endosc 2003 58 : 76 9.
13. Froehlich F, Wietlisbach V, Gonvers JJ, et al. Impact of colonic cleansing on quality and diagnostic yield of colonoscopy: the European panel of appropriateness of gastrointestinal endoscopy European multicenter study. Gastrointest Endosc 2005 61 : 378 384.
14. Parra-Blanco A, Nicolas-Perez D, Gimeno-Garcia A, et al. The timing of bowel preparation before colonoscopy determines the quality of cleansing, and is a significant factor contributing to the detection of flat lesions: a randomized trial. World J Gastroenterol 2006 12 : 6161 6166.
15. Rostom A, Jolicoeur E, Dube C, et al. A randomized prospective trial comparing different regimens of oral sodium phosphate and polyethylene glycol-based lavage solution in the preparation of patients for colonoscopy. Gastrointest Endosc 2006 64 : 544 552.
16. Aoun E, Abdul-Baki H, Azar C, et al. A randomized single-blind trial of split-dose PEG-electrolyte solution without dietary restriction compared with whole dose PEG-electrolyte solution with dietary restriction for colonoscopy preparation. Gastrointest Endosc 2005 62 : 213 218.
17. DiPalma JA, Rodriguez R, McGowan J, Cleveland MV. A randomized clinical study evaluating the safety and efficacy of a new, reduced-volume, oral sulfate colon-cleansing preparation for colonoscopy. Am J Gastroenterol 2009 104 : 2275 2284.