A pragmatic approach to the diagnosis of nodal micrometastases in early stage non-small cell lung cancer

Journal of Thoracic Oncology

Volumn 5, Issue 8, 2010, Pages 1206-1212

  Herpel, Esther ^a   Muley, Thomas ^b   Schneider, Thomas ^b   Palm, Elisa ^a   Kieslich De Hol, Dörthe ^a   Warth, Arne ^a   Meister, Michael ^b   Storz, Konstantina ^b   Schnabel, Philipp A ^a   Schirmacher, Peter ^a   Dienemann, Hendrik ^b   Hoffmann, Hans ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Immunohistochemistry; Lung cancer; Lymph node; Micrometastases; Prognostic impact

Indexed keywords

CYTOKERATIN ANTIBODY;

AGED; ARTICLE; CANCER DIAGNOSIS; CANCER PATIENT; CANCER STAGING; CANCER SURVIVAL; DISEASE FREE SURVIVAL; DISEASE MARKER; EARLY CANCER; FEMALE; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; LUNG NON SMALL CELL CANCER; LYMPH NODE METASTASIS; LYMPHADENECTOMY; MAJOR CLINICAL STUDY; MALE; MICROMETASTASIS; PRIORITY JOURNAL; PROGNOSIS; SENSITIVITY AND SPECIFICITY;

EID: 77955094413     PISSN: 15560864     EISSN: 15561380     Source Type: Journal    
DOI: 10.1097/JTO.0b013e3181e15cfd     Document Type: Article

References (36)

1. Le Chevalier T, Arriagada R, Pignon JP, et al. Should adjuvant chemotherapy become standard treatment in all patients with resected non- small-cell lung cancer? Lancet Oncol 2005;6:182-184.
2. Hoffmann H. Resected non-small-cell lung cancer stage i/ii: indication for adjuvant/neoadjuvant therapy? Lung Cancer 2004;45(Suppl 2):S91-S97.
3. Pfannschmidt J, Muley T, Bulzebruck H, et al. Prognostic assessment after surgical resection for non-small cell lung cancer: experiences in 2083 patients. Lung Cancer 2007;55:371-377.
4. UICC. TNM Classification of Malignant Tumors, 7th Ed. Hoboken: Wiley-Blackwell, 2009.
5. AJCC Cancer Staging Manual, 7th Ed. New York: Springer, 2009.
6. Hermanek P, Hutter RV, Sobin LH, et al. International union against cancer. Classification of isolated tumor cells and micrometastasis. Cancer 1999;86:2668-2673.
7. Mountain CF, Dresler CM. Regional lymph node classification for lung cancer staging. Chest 1997;111:1718-1723.
8. Naruke T, Goya T, Tsuchiya R, et al. Prognosis and survival in resected lung carcinoma based on the new international staging system. J Thorac Cardiovasc Surg 1988;96:440-447.
9. Wittekind CH, Meyer HJ, Bootz F (Eds.), TNM Classification of the UICC. Heidelberg: Springer, 2002.
10. Maruyama R, Sugio K, Mitsudomi T, et al. Relationship between early recurrence and micrometastases in the lymph nodes of patients with stage I non-small-cell lung cancer. J Thorac Cardiovasc Surg 1997;114:535-543.
11. Passlick B, Izbicki JR, Kubuschok B, et al. Immunohistochemical assessment of individual tumor cells in lymph nodes of patients with non-small-cell lung cancer. J Clin Oncol 1994;12:1827-1832.
12. Chen ZL, Perez S, Holmes EC, et al. Frequency and distribution of occult micrometastases in lymph nodes of patients with non-small-cell lung carcinoma. J Natl Cancer Inst 1993;85:493-498.
13. Kawano R, Hata E, Ikeda S, et al. Micrometastasis to lymph nodes in stage I left lung cancer patients. Ann Thorac Surg 2002;73:1558-1562.
14. Gu CD, Osaki T, Oyama T, et al. Detection of micrometastatic tumor cells in pn0 lymph nodes of patients with completely resected nonsmall cell lung cancer: impact on recurrence and survival. Ann Surg 2002;235:133-139. (Pubitemid 34062409)
15. Hermanek P. Disseminated tumor cells versus micrometastasis: definitions and problems. Anticancer Res 1999;19:2771-2774.
16. Pelkey TJ, Frierson HF Jr, Bruns DE. Molecular and immunological detection of circulating tumor cells and micrometastases from solid tumors. Clin Chem 1996;42:1369-1381.
17. Izbicki JR, Passlick B, Hosch SB, et al. Mode of spread in the early phase of lymphatic metastasis in non-small-cell lung cancer: significance of nodal micrometastasis. J Thorac Cardiovasc Surg 1996;112:623-630.
18. Singletary SE, Greene FL, Sobin LH. Classification of isolated tumor cells: clarification of the 6th edition of the American Joint Committee on cancer staging manual. Cancer 2003;98:2740-2741.
19. Tezel C, Ersev AA, Kiral H, et al. The impact of immunohistochemical detection of positive lymph nodes in early stage lung cancer. Thorac Cardiovasc Surg 2006;54:124-128.
20. Cserni G, Sapino A, Decker T. Discriminating between micrometastases and isolated tumor cells in a regional and institutional setting. Breast 2006;15:347-354.
21. Lardinois D, De Leyn P, Van Schil P, et al. ESTS guidelines for intraoperative lymph node staging in non-small cell lung cancer. Eur J Cardiothorac Surg 2006;30:787-792.
22. Ritter JH, Boucher LD, Wick MR. Peripheral pulmonary adenocarcino- mas with bronchioloalveolar features: immunophenotypes correlate with histologic patterns. Mod Pathol 1998;11:566-572.
23. Camilo R, Capelozzi VL, Siqueira SA, et al. Expression of p63, keratin 5/6, keratin 7, and surfactant-a in non-small cell lung carcinomas. Hum Pathol 2006;37:542-546.
24. Au NH, Cheang M, Huntsman DG, et al. Evaluation of immunohisto- chemical markers in non-small cell lung cancer by unsupervised hierarchical clustering analysis: a tissue microarray study of 284 cases and 18 markers. J Pathol 2004;204:101-109.
25. Latza U, Niedobitek G, Schwarting R, et al. Ber-ep4: new monoclonal antibody which distinguishes epithelia from mesothelial. J Clin Pathol 1990;43:213-219.
26. Wells CA, Heryet A, Brochier J, et al. The immunocytochemical detection of axillary micrometastases in breast cancer. Br J Cancer 1984;50:193-197.
27. Nakanishi Y, Ochiai A, Yamauchi Y, et al. Clinical implications of lymph node micrometastases in patients with colorectal cancers. A case control study. Oncology 1999;57:276-280.
28. Osaki T, Oyama T, Gu CD, et al. Prognostic impact of micrometastatic tumor cells in the lymph nodes and bone marrow of patients with completely resected stage I non-small-cell lung cancer. J Clin Oncol 2002;20:2930-2936. (Pubitemid 34728886)
29. Rena O, Carsana L, Cristina S, et al. Lymph node isolated tumor cells and micrometastases in pathological stage I non-small cell lung cancer: prognostic significance. Eur J Cardiothorac Surg 2007;32:863-867.
30. Marchevsky AM, Qiao JH, Krajisnik S, et al. The prognostic significance of intranodal isolated tumor cells and micrometastases in patients with non-small cell carcinoma of the lung. J Thorac Cardiovasc Surg 2003;126:551-557.
31. Coello MC, Luketich JD, Litle VR, et al. Prognostic significance of micrometastasis in non-small-cell lung cancer. Clin Lung Cancer 2004; 5:214-225.
32. Li SH, Wang Z, Liu XY, et al. Gene diagnosis and prognostic significance of lymph node micrometastasis after complete resection of histo- logically node-negative non-small cell lung cancer. World J Surg 2008; 32:1651-1656.
33. Hashimoto T, Kobayashi Y, Ishikawa Y, et al. Prognostic value of genetically diagnosed lymph node micrometastasis in non-small cell lung carcinoma cases. Cancer Res 2000;60:6472-6478.
34. Xi L, Coello MC, Litle VR, et al. A combination of molecular markers accurately detects lymph node metastasis in non-small cell lung cancer patients. Clin Cancer Res 2006;12:2484-2491.
35. Saintigny P, Coulon S, Kambouchner M, et al. Real-time RT-PCR detection of ck19, ck7 and muc1 mRNA for diagnosis of lymph node micrometastases in non small cell lung carcinoma. Int J Cancer 2005; 115:777-782.
36. Maeda J, Inoue M, Okumura M, et al. Detection of occult tumor cells in lymph nodes from non-small cell lung cancer patients using reverse tran- scription-polymerase chain reaction for carcinoembryonic antigen mRNA with the evaluation of its sensitivity. Lung Cancer 2006;52:235-240.